CO6700838A2 - Compuestos sustituidos de banzamida - Google Patents

Compuestos sustituidos de banzamida

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Publication number
CO6700838A2
CO6700838A2 CO13057218A CO13057218A CO6700838A2 CO 6700838 A2 CO6700838 A2 CO 6700838A2 CO 13057218 A CO13057218 A CO 13057218A CO 13057218 A CO13057218 A CO 13057218A CO 6700838 A2 CO6700838 A2 CO 6700838A2
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Colombia
Prior art keywords
aryl
heteroaryl
group
cycloalkyl
alkyl
Prior art date
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CO13057218A
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English (en)
Inventor
Melanie Reich
Stefan Schunk
Ruth Jostock
Vry Jean De
Christa Kneip
Tieno Germann
Michael Engels
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Gruenenthal Chemie
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Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CO6700838A2 publication Critical patent/CO6700838A2/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

Compuesto sustituido de benzamida de la fórmula general (I),en donde, a representa 0 ó 1; t representa 1, 2 ó 3; b representa 0. 1 ó 2; c y d independientes entre sí, respectivamente, representan 0, 1 ó 2 con a condición de que el ciclo contenga 7 elementos del anillo como máximo; X representa N(R) o C(R)(H); D representa uno de los siguientes residuos D1 o D2 q representa 0 ó 1; s representa 0 ó 1; r representa 1. 2 ó 3; B representa C(=O), S(=O)o al grupo C(=Q)-N(R), en donde su átomo de nitrógeno está unido al residuo R; Qy Q, independientes entre sí, representan C, CH o N, respectivamente; Rrepresenta alquilo C, arilo, heteroarilo, CH(arilo), cicloalquilo C, heterociclilo, o bien, representar un arilo, heteroarilo, CH(arilo), cicloalquilo o heterociclilo unido por un grupo alquilo C, un grupo alquenilo C, o un grupo alquinilo C, Rrepresenta H, alquilo C, cicloalquilo C, heterociclilo, arilo, heteroarilo, o bien, representa un cicloalquilo C, heterociclilo, arilo o heteroarilo unido por un grupo alquileno C; Ry Rjunto con el grupo-Q-Q- al que están unido, forman un ciclo, el cual puede ser anillado, no sustituido o sustituido en uno o varios, a modo de ejemplo, 1, 2 ó 3 de sus elementos del anillo de carbono con uno o más, a modo de ejemplo, 1, 2, 3 6ó 4 sustituyentes independientes entre sí, seleccionados a partir del grupo formado por F, CI, Br, I, CF, alquilo C, O-alquilo C, OH, OCF, SH, SCF, arilo y heteroarilo y/o con al menos un, a modo de ejemplo, 1 ó 2, arilo o heteroarilo, en donde, el ciclo es saturado, en forma simple o múltiple, a modo de ejemplo, una o dos veces, no saturado o aromático, tiene de 4-, 5, 6- ó 7 elementos, y que puede contener, en cada caso, uno o más, a modo de ejemplo, 1, 2 ó 3, heteroátomos o grupos de heteroátomos independientes entre sí, seleccionados a partir del grupo formado por N, NR, O, S, S(=O) y S(=O); en donde el residuo Rsignifica H, alquilo C, C(=O)-R, cicloalquilo C, arilo, heteroarilo, o bien, significa un cicloalquilo C, arilo o heteroarilo unido por un grupo alquilo C, y Rsignifica alquilo C, cicloalquilo C, arilo, heteroarilo o un cicloalquilo C, arilo o heteroarilo unido por un grupo alquileno Cel proceso para su elaboración, medicamento que contienen estos compuestos y el uso de compuesto sustituidos de bezaminda para la elaboración de medicamento.
CO13057218A 2010-09-22 2013-03-22 Compuestos sustituidos de banzamida CO6700838A2 (es)

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US (1) US8680159B2 (es)
EP (1) EP2619178A1 (es)
JP (1) JP2013540750A (es)
KR (1) KR20140000682A (es)
CN (1) CN103097354A (es)
AR (1) AR083167A1 (es)
AU (1) AU2011304666A1 (es)
BR (1) BR112013008667A2 (es)
CA (1) CA2811796A1 (es)
CL (1) CL2013000787A1 (es)
CO (1) CO6700838A2 (es)
EA (1) EA201300388A1 (es)
EC (1) ECSP13012519A (es)
IL (1) IL225350A0 (es)
MX (1) MX2013003309A (es)
PE (1) PE20131350A1 (es)
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WO (1) WO2012038081A1 (es)

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WO2014186704A2 (en) * 2013-05-17 2014-11-20 N30 Pharmaceuticals, Inc. Novel compounds for the treatment of cystic fibrosis
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