PE20142081A1 - Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodo de uso de los mismos - Google Patents
Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodo de uso de los mismosInfo
- Publication number
- PE20142081A1 PE20142081A1 PE2014000264A PE2014000264A PE20142081A1 PE 20142081 A1 PE20142081 A1 PE 20142081A1 PE 2014000264 A PE2014000264 A PE 2014000264A PE 2014000264 A PE2014000264 A PE 2014000264A PE 20142081 A1 PE20142081 A1 PE 20142081A1
- Authority
- PE
- Peru
- Prior art keywords
- quinurenin
- replaced
- substituted
- pharmaceutical compositions
- heterocicloalkyl
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
REFERIDO A UN COMPUESTO DE LA FORMULA (I) Y SALES FARMACEUTICAMENTE ACEPTABLES Y PROFARMACOS DE LOS MISMOS DONDE X E Y SE ELIGEN ENTRE -N- , -CH-; R1 ES ARILO SUSTITUIDO O HETEROARILO SUSTITUIDO; R2 ES H O ALQUILO INFERIOR SUSTITUIDO; R3 ES H, HALO, ALQUILO ENTRE OTROS; L ES -C(O)O-, -C(O)N(R4), -N(R4)S(O)2-, ENTRE OTROS; R4 Y R5 TOMADOS JUNTO CON EL N AL QUE ESTAN UNIDOS FORMAN UN ANILLO HETEROCICLOALQUILO DE 4 A 7 MIEMBROS SUSTITUIDOS, QUE ESTA CONDENSADO CON UN ANILLO CICLOALQUILO SUSTITUIDO, HETEROCICLOALQUILO SUSTITUIDO ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, SIENDO UTIL PARA EL TRATAMIENTO DE UNA AFECCION O UN TRASTORNO MEDIADO POR LA ACTIVIDAD DE LA QUINURENINA 3-MONOOXIGENASA.
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