BR112013018732A2 - novos derivados de amida de aril-benzocicloalquila - Google Patents

novos derivados de amida de aril-benzocicloalquila

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Publication number
BR112013018732A2
BR112013018732A2 BR112013018732A BR112013018732A BR112013018732A2 BR 112013018732 A2 BR112013018732 A2 BR 112013018732A2 BR 112013018732 A BR112013018732 A BR 112013018732A BR 112013018732 A BR112013018732 A BR 112013018732A BR 112013018732 A2 BR112013018732 A2 BR 112013018732A2
Authority
BR
Brazil
Prior art keywords
benzocycloalkyl
amide derivatives
new aryl
compounds
aryl
Prior art date
Application number
BR112013018732A
Other languages
English (en)
Inventor
Alfred Binggeli
Anish Ashok Konkar
Bernd Kuhn
Cornelia Hertel
Haiyan Wang
Hans P Maerki
Holger Kuehne
Johannes Aebi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013018732A2 publication Critical patent/BR112013018732A2/pt

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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Abstract

novos derivados de amida de aril-benzocicloalquila a invenção provê compostos novos tendo a fórmula geral (i), em que r^ 1^, r^ 2^, r^ 3^, r^ 4^, r^ 5^, r^ 6^, r^ 7^, r^ 8^, r^ 9^, r^ 10^, r^ 11^, r^ 12^, a^ 1^, a^ 2^ e n são como descrito aqui, composições incluindo os compostos e métodos de utilizar os compostos.
BR112013018732A 2011-01-24 2012-01-18 novos derivados de amida de aril-benzocicloalquila BR112013018732A2 (pt)

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BR112023017461A2 (pt) 2021-03-04 2023-09-26 Cytokinetics Inc Compostos, composição farmacêutica, métodos de tratamento de doença cardíaca, de uma doença ou afecção associada à cardiomiopatia hipertrófica, de uma doença ou afecção que está associada ao espessamento secundário da parede do ventrículo esquerdo, de uma doença ou afecção associada à pequena cavidade ventricular esquerda e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia miocárdica ou fibrose cardíaca, de uma doença ou afecção selecionada a partir de distrofias musculares e doenças de armazenamento de glicogênio, e, método de inibição do sarcômero cardíaco
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US20130018055A1 (en) 2013-01-17
CN103328436A (zh) 2013-09-25
EP2668155A2 (en) 2013-12-04
KR20140005271A (ko) 2014-01-14
EP2668155B1 (en) 2014-11-26
WO2012101011A2 (en) 2012-08-02
RU2013136777A (ru) 2015-03-10
ES2529509T3 (es) 2015-02-20
US8592426B2 (en) 2013-11-26
AR084913A1 (es) 2013-07-10
CA2823781A1 (en) 2012-08-02
JP2014511359A (ja) 2014-05-15
MX343225B (es) 2016-10-28
WO2012101011A3 (en) 2012-09-20
JP5986108B2 (ja) 2016-09-06
HK1187910A1 (en) 2014-04-17
MX2013008312A (es) 2013-09-06

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