BR112015022804A2 - novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina - Google Patents

novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina

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Publication number
BR112015022804A2
BR112015022804A2 BR112015022804A BR112015022804A BR112015022804A2 BR 112015022804 A2 BR112015022804 A2 BR 112015022804A2 BR 112015022804 A BR112015022804 A BR 112015022804A BR 112015022804 A BR112015022804 A BR 112015022804A BR 112015022804 A2 BR112015022804 A2 BR 112015022804A2
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BR
Brazil
Prior art keywords
pyrrol
analogues
new
octahidro
derivatives
Prior art date
Application number
BR112015022804A
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English (en)
Inventor
Hunziker Daniel
Tang Guozhi
Mauser Harald
Hert Jérôme
Wang Lisha
Mattei Patrizio
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015022804A2 publication Critical patent/BR112015022804A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1/1 resumo novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina a invenção proporciona novos compostos que possuem a fórmula geral (i) em que r1, y, a, w, r2 , m, n, p e q são tal como aqui descritos, as composições incluindo os compostos e métodos de utilização dos compostos.
BR112015022804A 2013-03-12 2014-03-11 novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina BR112015022804A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13158724 2013-03-12
PCT/EP2014/054631 WO2014139978A1 (en) 2013-03-12 2014-03-11 New octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors

Publications (1)

Publication Number Publication Date
BR112015022804A2 true BR112015022804A2 (pt) 2017-07-18

Family

ID=47843184

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022804A BR112015022804A2 (pt) 2013-03-12 2014-03-11 novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina

Country Status (33)

Country Link
US (2) US20150376194A1 (pt)
EP (1) EP2970256B1 (pt)
JP (2) JP6483034B2 (pt)
KR (1) KR20150126036A (pt)
CN (1) CN105073748B (pt)
AR (1) AR095079A1 (pt)
AU (1) AU2014230943B8 (pt)
BR (1) BR112015022804A2 (pt)
CA (1) CA2901047A1 (pt)
CL (1) CL2015002386A1 (pt)
CR (1) CR20150436A (pt)
DK (1) DK2970256T3 (pt)
EA (1) EA035015B1 (pt)
ES (1) ES2763417T3 (pt)
HK (1) HK1211935A1 (pt)
HR (1) HRP20192274T1 (pt)
HU (1) HUE046776T2 (pt)
IL (1) IL240796B (pt)
LT (1) LT2970256T (pt)
MA (1) MA38432B1 (pt)
MX (1) MX2015011311A (pt)
MY (1) MY177574A (pt)
PE (1) PE20151605A1 (pt)
PH (1) PH12015501934B1 (pt)
PL (1) PL2970256T3 (pt)
PT (1) PT2970256T (pt)
RS (1) RS59682B1 (pt)
SG (1) SG11201507396YA (pt)
SI (1) SI2970256T1 (pt)
TW (1) TWI678368B (pt)
UA (1) UA115354C2 (pt)
WO (1) WO2014139978A1 (pt)
ZA (1) ZA201505944B (pt)

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