PE20131350A1 - Compuestos sustituidos de benzamida - Google Patents

Compuestos sustituidos de benzamida

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Publication number
PE20131350A1
PE20131350A1 PE2013000618A PE2013000618A PE20131350A1 PE 20131350 A1 PE20131350 A1 PE 20131350A1 PE 2013000618 A PE2013000618 A PE 2013000618A PE 2013000618 A PE2013000618 A PE 2013000618A PE 20131350 A1 PE20131350 A1 PE 20131350A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
aryl
dihydro
compounds
Prior art date
Application number
PE2013000618A
Other languages
English (en)
Inventor
Melanie Reich
Stefan Schunk
Ruth Jostock
Vry Jean De
Christa Kneip
Tieno Germann
Michael Engels
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20131350A1 publication Critical patent/PE20131350A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BENZAMIDA DE FORMULA (I) DONDE a ES 0 O 1; t ES DE 1 A 3; b ES DE 0 A 2; c Y d SON CADA UNO DE 0 A 2; X ES N(R9a) O C(R9b)H, EN DONDE R9a ES CICLOALQUILO(C3-C8), ARILO, HETEROARILO, ENTRE OTROS; R9b ES ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ARILO, ENTRE OTROS; D ES D1, ENTRE OTROS, EN DONDE q ES 0 O 1; B ES C(=O), S(=O)2, ENTRE OTROS; R1 ES ALQUILO(C1-C9), ARILO, HETEROCICLILO, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS; R5 ES F, Cl, CF3, OCF3, ALQUILO(C1-C6), ENTRE OTROS; R6 ES F, OH, NO2, NH2, NH(ALQUILO C1-C6), ENTRE OTROS; R7 ES H, ALQUILO(C1-C6), HETEROCICLILO, ARILO, ENTRE OTROS; R8 ES CF3, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: AMIDA DE ACIDO 3-[(2-CLOR-BENZOILO)AMINO]-N-[2-(1-PIRIDIN-4-IL-PIPERIDIN-4-IL)-ETIL]-2,3-DIHIDRO-1H-INDEN-5-CARBOXILICO; AMIDA DE ACIDO (1R)-1-(4-CLOR-3-OXO-1,2-DIHIDRO-ISOINDOL-2-IL)-N-METIL-N-(1-PIRIDIN-4-IL-PIPERIDIN-4-IL)-2,3-DIHIDRO-1H-INDEN-5-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE BRADIQUININA 1 (B1R) SIENDO UTILES EN EL TRATAMIENTO DE DOLOR, FIBROSIS QUISTICA, ENTERITIS, ESCLEROSIS MULTIPLE
PE2013000618A 2010-09-22 2011-09-21 Compuestos sustituidos de benzamida PE20131350A1 (es)

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EP10010200 2010-09-22

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PE20131350A1 true PE20131350A1 (es) 2013-12-08

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US (1) US8680159B2 (es)
EP (1) EP2619178A1 (es)
JP (1) JP2013540750A (es)
KR (1) KR20140000682A (es)
CN (1) CN103097354A (es)
AR (1) AR083167A1 (es)
AU (1) AU2011304666A1 (es)
BR (1) BR112013008667A2 (es)
CA (1) CA2811796A1 (es)
CL (1) CL2013000787A1 (es)
CO (1) CO6700838A2 (es)
EA (1) EA201300388A1 (es)
EC (1) ECSP13012519A (es)
IL (1) IL225350A0 (es)
MX (1) MX2013003309A (es)
PE (1) PE20131350A1 (es)
TW (1) TW201217312A (es)
WO (1) WO2012038081A1 (es)

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