ZW6189A1 - Anti-aggregatory peptides - Google Patents

Anti-aggregatory peptides

Info

Publication number
ZW6189A1
ZW6189A1 ZW61/89A ZW6189A ZW6189A1 ZW 6189 A1 ZW6189 A1 ZW 6189A1 ZW 61/89 A ZW61/89 A ZW 61/89A ZW 6189 A ZW6189 A ZW 6189A ZW 6189 A1 ZW6189 A1 ZW 6189A1
Authority
ZW
Zimbabwe
Prior art keywords
arg
alk
harg
alpha
substituted derivative
Prior art date
Application number
ZW61/89A
Other languages
English (en)
Inventor
El-Fehail Ali Fadia
Martin Samanen James
John Shebuski Ronald
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZW6189A1 publication Critical patent/ZW6189A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZW61/89A 1988-05-09 1989-05-03 Anti-aggregatory peptides ZW6189A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19151588A 1988-05-09 1988-05-09
US33530689A 1989-04-10 1989-04-10

Publications (1)

Publication Number Publication Date
ZW6189A1 true ZW6189A1 (en) 1990-05-09

Family

ID=26887117

Family Applications (1)

Application Number Title Priority Date Filing Date
ZW61/89A ZW6189A1 (en) 1988-05-09 1989-05-03 Anti-aggregatory peptides

Country Status (13)

Country Link
US (1) US5849690A (de)
EP (1) EP0341915B1 (de)
JP (1) JP2755351B2 (de)
KR (1) KR900018136A (de)
AT (1) ATE158305T1 (de)
AU (1) AU3458889A (de)
DE (1) DE68928321T2 (de)
DK (1) DK222989A (de)
FI (1) FI892208A (de)
HU (1) HU205368B (de)
NO (1) NO891870L (de)
PT (1) PT90512B (de)
ZW (1) ZW6189A1 (de)

Families Citing this family (62)

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US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
JPH04503951A (ja) * 1988-12-20 1992-07-16 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 創傷治癒に活性のあるポリペプチド―ポリマー複合体
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
US5686570A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5344783A (en) * 1989-06-16 1994-09-06 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
EP0410537A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen-Rezeptor-Antagonisten
US5061693A (en) * 1989-07-28 1991-10-29 Merck & Co., Inc. Fibrinogen receptor antagonists
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5338723A (en) * 1989-10-13 1994-08-16 Merck & Co., Inc. Fibrinogen receptor antagonists
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2073696A1 (en) * 1990-02-02 1991-08-03 Peter L. Barker Cyclic peptides containing arg-gly-asp flanked by proline
DE4009506A1 (de) * 1990-03-24 1991-09-26 Hoechst Ag Hydantoinderivate
AU660926B2 (en) * 1990-04-06 1995-07-13 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5721210A (en) * 1990-07-09 1998-02-24 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
JPH06502407A (ja) * 1990-11-02 1994-03-17 ジェネンテク，インコーポレイテッド 血小板凝集阻害剤
EP0570507A4 (en) * 1991-02-05 1994-09-21 Smithkline Beecham Corp Anti-aggregatory peptides containing an aromatic ester or amide
AU666853B2 (en) * 1991-04-05 1996-02-29 Genentech Inc. Platelet aggregation inhibitors having high specificity for GP IIbIIIa
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
ZA924760B (en) * 1991-06-28 1993-03-31 Smithkline Beecham Corp Bicyclic fibrinogen antagonists
WO1993000108A1 (en) * 1991-06-28 1993-01-07 Corvas International, Inc. Novel inhibitors of platelet aggregation
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
FR2692899B1 (fr) * 1992-06-30 1994-08-19 Adir Nouveaux dérivés peptidiques actifs dans les processus d'adhésion cellulaire, leur procédé de préparation et les compositions pharmaceutiques qui les renferment.
FR2693107B1 (fr) * 1992-07-01 1994-09-23 Chauvin Laboratoire Moyens pour la prévention de la cataracte secondaire.
AU5594294A (en) * 1992-11-18 1994-06-08 Du Pont Merck Pharmaceutical Company, The Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5440016A (en) * 1993-06-18 1995-08-08 Torrey Pines Institute For Molecular Studies Peptides of the formula (KFmoc) ZZZ and their uses
ATE195949T1 (de) * 1993-06-18 2000-09-15 Jolla Cancer Res Found Verfahren und zusammensetzungen zur behandlung der thrombose
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
AU2958195A (en) * 1994-06-29 1996-01-25 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
GB9524630D0 (en) * 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
AU6311996A (en) * 1995-07-06 1997-02-05 Zeneca Limited Peptide inhibitors of fibronectine
GB9613112D0 (en) 1996-06-21 1996-08-28 Zeneca Ltd Chemical compounds
CA2320900C (en) 1998-03-19 2009-10-27 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
AU3748399A (en) 1998-04-16 1999-11-01 Texas Biotechnology Corporation N,n-disubstituted amides that inhibit the binding of integrins to their receptors
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US20090093016A1 (en) * 2006-01-17 2009-04-09 N.V. Organon Selective Enzymatic Hydrolysis of C-Terminal Tert-Butyl Esters of Peptides
MX342120B (es) 2010-07-09 2016-09-14 William Owen Wilkison Combinación de sistema de liberación prolongada/inmediata para productos farmacéuticos de vida media corta como el remogliflozin.
US10875875B2 (en) 2017-04-26 2020-12-29 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof
WO2019239879A1 (ja) * 2018-06-15 2019-12-19 国立大学法人東京工業大学 アミドの製造方法
AU2019284746B2 (en) * 2018-06-15 2023-08-17 Yokogawa Electric Corporation Method for producing amide
EP3904317A4 (de) * 2018-12-25 2022-09-21 Tokyo Institute of Technology Verfahren zur herstellung von amid
EP4000597A1 (de) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptid und zusammensetzungen mit tetrapeptiden

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397842A (en) * 1980-03-13 1983-08-09 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
US4544500A (en) * 1982-04-14 1985-10-01 Scripps Clinic And Research Foundation Synthetic foot and mouth disease antigen
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
DE3382031D1 (en) * 1982-08-04 1991-01-10 Jolla Cancer Res Found Polypeptide.
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4732971A (en) * 1985-06-03 1988-03-22 Eli Lilly And Company Synthetic vaccines for foot and mouth disease
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
NZ230742A (en) * 1986-10-09 1991-03-26 Smithkline Beckman Corp Thrombolytic composition comprising a plasminogen activator (tpa, uk or sk) and a thromboxane receptor antagonist; kits thereof; and process for preparation thereof
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
EP0275748B1 (de) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Peptid-Derivate und deren Verwendung in der Therapie
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
AU3040589A (en) * 1988-02-22 1989-09-06 Upjohn Company, The Homoarginine-based peptides as platelet aggregation inhibitors

Also Published As

Publication number Publication date
DK222989A (da) 1989-11-10
NO891870L (no) 1989-11-10
US5849690A (en) 1998-12-15
JP2755351B2 (ja) 1998-05-20
DK222989D0 (da) 1989-05-05
KR900018136A (ko) 1990-12-20
ATE158305T1 (de) 1997-10-15
DE68928321D1 (de) 1997-10-23
FI892208A0 (fi) 1989-05-08
PT90512A (pt) 1989-11-30
AU3458889A (en) 1989-11-09
PT90512B (pt) 1994-10-31
EP0341915A2 (de) 1989-11-15
EP0341915B1 (de) 1997-09-17
HUT49891A (en) 1989-11-28
JPH0262892A (ja) 1990-03-02
FI892208A (fi) 1989-11-10
HU205368B (en) 1992-04-28
DE68928321T2 (de) 1998-04-23
EP0341915A3 (de) 1990-12-12
NO891870D0 (no) 1989-05-08

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