ZM4984A1 - 2,5-disubstituted-4(3h)-pyrimidones having histamine h2-recepter antagonist activity - Google Patents

2,5-disubstituted-4(3h)-pyrimidones having histamine h2-recepter antagonist activity

Info

Publication number
ZM4984A1
ZM4984A1 ZM49/84A ZM4984A ZM4984A1 ZM 4984 A1 ZM4984 A1 ZM 4984A1 ZM 49/84 A ZM49/84 A ZM 49/84A ZM 4984 A ZM4984 A ZM 4984A ZM 4984 A1 ZM4984 A1 ZM 4984A1
Authority
ZM
Zambia
Prior art keywords
pyrimidones
histamine
disubstituted
antagonist activity
recepter
Prior art date
Application number
ZM49/84A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZM4984A1 publication Critical patent/ZM4984A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZM49/84A 1983-09-21 1984-09-18 2,5-disubstituted-4(3h)-pyrimidones having histamine h2-recepter antagonist activity ZM4984A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/534,426 US4772704A (en) 1983-09-21 1983-09-21 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity

Publications (1)

Publication Number Publication Date
ZM4984A1 true ZM4984A1 (en) 1985-05-21

Family

ID=24129972

Family Applications (1)

Application Number Title Priority Date Filing Date
ZM49/84A ZM4984A1 (en) 1983-09-21 1984-09-18 2,5-disubstituted-4(3h)-pyrimidones having histamine h2-recepter antagonist activity

Country Status (36)

Country Link
US (1) US4772704A (xx)
JP (1) JPH0643310B2 (xx)
KR (1) KR900001198B1 (xx)
AR (2) AR242385A1 (xx)
AT (1) AT387965B (xx)
AU (1) AU583479B2 (xx)
BE (1) BE900652A (xx)
CA (1) CA1260463A (xx)
CH (1) CH665840A5 (xx)
CS (1) CS249147B2 (xx)
CY (1) CY1561A (xx)
DD (1) DD226881A5 (xx)
DE (1) DE3434578A1 (xx)
DK (1) DK162987C (xx)
ES (4) ES8607253A1 (xx)
FI (1) FI83868C (xx)
FR (1) FR2552082B1 (xx)
GB (1) GB2146994B (xx)
GR (1) GR80439B (xx)
HK (1) HK73790A (xx)
HU (1) HU193227B (xx)
IE (1) IE58083B1 (xx)
IL (1) IL72990A (xx)
IT (1) IT1176739B (xx)
LU (1) LU85550A1 (xx)
NL (1) NL8402898A (xx)
NO (1) NO161561C (xx)
NZ (1) NZ209572A (xx)
OA (1) OA07820A (xx)
PT (1) PT79256B (xx)
SE (1) SE463209B (xx)
SG (1) SG60890G (xx)
YU (1) YU45205B (xx)
ZA (1) ZA847345B (xx)
ZM (1) ZM4984A1 (xx)
ZW (1) ZW16084A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (xx) * 1978-02-13 1983-03-05 Smith Kline French Lab
ES477520A1 (es) * 1978-02-25 1979-06-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevas penicilinas.
AU527202B2 (en) * 1978-04-11 1983-02-24 Smith Kline & French Laboratories Limited 2-aminopyrimidones
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
AU531142B2 (en) * 1979-04-04 1983-08-11 Smith Kline & French Laboratories Limited 2 amino- pyimindones
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
US4352933A (en) * 1981-02-06 1982-10-05 Smithkline Beckman Corporation Chemical methods and intermediates for preparing substituted pyrimidinones
CA1206151A (en) * 1981-12-28 1986-06-17 Richard P. Pioch Pyrimidone anti-ulcer agents
US4468399A (en) * 1981-12-28 1984-08-28 Eli Lilly And Company 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
CA1275097A (en) * 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives

Also Published As

Publication number Publication date
PT79256A (en) 1984-10-01
AU583479B2 (en) 1989-05-04
ES536054A0 (es) 1986-05-16
SE8404729L (sv) 1985-03-22
DD226881A5 (de) 1985-09-04
DK162987C (da) 1992-06-01
LU85550A1 (fr) 1985-06-04
ES544213A0 (es) 1987-04-01
IE58083B1 (en) 1993-06-30
IL72990A (en) 1990-07-12
DK162987B (da) 1992-01-06
GB2146994B (en) 1987-09-03
ES8704465A1 (es) 1987-04-01
FR2552082B1 (fr) 1987-02-20
CY1561A (en) 1991-03-22
JPH0643310B2 (ja) 1994-06-08
IT8422744A1 (it) 1986-03-20
FI843643A0 (fi) 1984-09-18
NL8402898A (nl) 1985-04-16
ES551500A0 (es) 1987-03-16
OA07820A (fr) 1986-11-20
IE842406L (en) 1985-03-21
IT1176739B (it) 1987-08-18
SG60890G (en) 1990-09-07
NO161561C (no) 1989-08-30
FR2552082A1 (fr) 1985-03-22
DK450484D0 (da) 1984-09-20
GB8423863D0 (en) 1984-10-24
ATA300984A (de) 1988-09-15
HU193227B (en) 1987-08-28
KR900001198B1 (ko) 1990-02-28
SE8404729D0 (sv) 1984-09-20
AT387965B (de) 1989-04-10
GR80439B (en) 1985-01-22
KR850002259A (ko) 1985-05-10
ES8704155A1 (es) 1987-03-16
US4772704A (en) 1988-09-20
NZ209572A (en) 1988-05-30
YU45205B (en) 1992-05-28
AU3335184A (en) 1985-03-28
BE900652A (fr) 1985-03-21
FI843643L (fi) 1985-03-22
FI83868B (fi) 1991-05-31
ZW16084A1 (en) 1985-01-16
NO843726L (no) 1985-03-22
DK450484A (da) 1985-03-22
PT79256B (en) 1986-11-20
ES551501A0 (es) 1987-01-16
YU161384A (en) 1987-12-31
SE463209B (sv) 1990-10-22
AR242385A1 (es) 1993-03-31
HUT35259A (en) 1985-06-28
NO161561B (no) 1989-05-22
CH665840A5 (de) 1988-06-15
CS249147B2 (en) 1987-03-12
FI83868C (fi) 1991-09-10
ES8702897A1 (es) 1987-01-16
ES8607253A1 (es) 1986-05-16
IT8422744A0 (it) 1984-09-20
AR242789A1 (es) 1993-05-31
HK73790A (en) 1990-09-28
GB2146994A (en) 1985-05-01
JPS6087271A (ja) 1985-05-16
DE3434578A1 (de) 1985-04-11
CA1260463A (en) 1989-09-26
ZA847345B (en) 1985-06-26

Similar Documents

Publication Publication Date Title
EP0145023A3 (en) 3, 3", 4" -tri-o-acylspiramycin i
CS636084A2 (en) Zpusob vyroby 16-fluor-16,17-didehydroprostanoidu
ZM4984A1 (en) 2,5-disubstituted-4(3h)-pyrimidones having histamine h2-recepter antagonist activity
CS39084A2 (en) Zpusob stanoveni obsahu kyseliny v oleji, zejmena v chladicich zarizenich pohanenych freonem
CS480584A1 (en) Rezaci zarizeni plastiskych hmot, zvlaste tramcu keramicke hmoty
SU1246568A1 (ru) 2`,2`,5,7-тетраметил-6-оксоспиро-(1,3-диазаадамантан- 2,4′ -тетрагидротиопиран), обладающий противостафилококковой активностью
CS367483A1 (en) Arizeni pro zajisteni rovnomernosti indukcniho ohrevu, zejmena v indukcnich ohrivacich kovarenskych strojich
CS496283A1 (en) Zpusob vyroby teplotne citliveho cidla, zarizeni pro mereni teplot v mikrostrukturach biologickych materialu
IE810940L (en) 17-substituted-6-desoxy-7,8-dihydro-6ó-methylnoroxymorphone¹narcotic antagonists
CS433083A1 (en) Dvojstupnova, predlohova prevodovka s lamelovymi trecimi spojkami
CS586583A1 (en) Zpusob zvyseni soudrznosti pryzovych vyrobku, zejmena hadic, s vicevrstvou vyztuzi
CS752283A1 (en) Tryskovy tkaci stroj s oboustrannym prohozem, zejmena vzduchovym
CS183783A1 (en) Vykyvne ulozeni, zejmena ulozeni listu vetrneho motoru s vodorovnou osou otaceni
CS146183A1 (en) Zpusob vyroby polymernich materialu s hydroxyesterovymi vazbami, zejmena technicke pryze
SU1221878A1 (ru) I′ -БЕНЗИЛ-5,7-ДИМЕТИЛ-6-ОКСОСПИРО-(1,3-ДИАЗААДАМАНТАН- 2,4′ -ПИПЕРИДИН), ОБЛАДАЮЩИЙ α -АДРЕНОБЛОКИРУЮЩЕЙ АКТИВНОСТЬЮ
CS257283A1 (en) Spojka, zejmena pro pruzne spojeni vretene armatury s elektrickym servomotorem tahlovym
CS363383A1 (en) Mechanicke prevodove ustroji s reverzaci pro pohon vozidel, zejmena traktoru
CS484583A1 (en) Zarizeni pro spojovani privesu s taznym strojem, opatrene signalizaci
CS1053984A1 (en) Upevneni vzduchove pruziny,zejmena v podvozku kolejoveho vozidla
CS465684A1 (en) Elektricky stroj tocivy, zejmena v pevnem zaveru
CS46283A1 (en) Zapojeni dvou asynchronnich krouzkovych motoru, pracujicich do mechanickeho uzlu
CS420383A1 (en) Samocinne podavaci ustroji tiskarskych stroju, zejmena rozmnozovacich
CS347483A1 (en) Staveci zarizeni pracovnich valcu, zejmena kalandru
CS28783A1 (en) Antistaticky modifikovane polyamidy, hlavne vlakna
CS241583A1 (en) Kompresor, hlavne hermeticky chladivovy kompresor