ES544213A0 - Un procedimiento para la preparacion de nuevas 4 (3h)-piri- midonas 2,5-disustituidas - Google Patents

Un procedimiento para la preparacion de nuevas 4 (3h)-piri- midonas 2,5-disustituidas

Info

Publication number
ES544213A0
ES544213A0 ES544213A ES544213A ES544213A0 ES 544213 A0 ES544213 A0 ES 544213A0 ES 544213 A ES544213 A ES 544213A ES 544213 A ES544213 A ES 544213A ES 544213 A0 ES544213 A0 ES 544213A0
Authority
ES
Spain
Prior art keywords
midonas
disstituted
piri
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES544213A
Other languages
English (en)
Other versions
ES8704465A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES544213A0 publication Critical patent/ES544213A0/es
Publication of ES8704465A1 publication Critical patent/ES8704465A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES544213A 1983-09-21 1985-06-14 Un procedimiento para la preparacion de nuevas 4 (3h)-piri- midonas 2,5-disustituidas Expired ES8704465A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/534,426 US4772704A (en) 1983-09-21 1983-09-21 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity

Publications (2)

Publication Number Publication Date
ES544213A0 true ES544213A0 (es) 1987-04-01
ES8704465A1 ES8704465A1 (es) 1987-04-01

Family

ID=24129972

Family Applications (4)

Application Number Title Priority Date Filing Date
ES536054A Expired ES8607253A1 (es) 1983-09-21 1984-09-19 Un procedimiento para la preparacion de nuevos 4 (3h)-pirimidonas 2,5-disustituidas.
ES544213A Expired ES8704465A1 (es) 1983-09-21 1985-06-14 Un procedimiento para la preparacion de nuevas 4 (3h)-piri- midonas 2,5-disustituidas
ES551500A Expired ES8704155A1 (es) 1983-09-21 1986-01-31 Un procedimiento para la preparacion de nuevas 4(3h)-piri-midonas 2,5 disustituidas
ES551501A Expired ES8702897A1 (es) 1983-09-21 1986-01-31 Un procedimiento para la preparacion de nuevas 4(3h)-piri-midonas 2,5 disustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES536054A Expired ES8607253A1 (es) 1983-09-21 1984-09-19 Un procedimiento para la preparacion de nuevos 4 (3h)-pirimidonas 2,5-disustituidas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES551500A Expired ES8704155A1 (es) 1983-09-21 1986-01-31 Un procedimiento para la preparacion de nuevas 4(3h)-piri-midonas 2,5 disustituidas
ES551501A Expired ES8702897A1 (es) 1983-09-21 1986-01-31 Un procedimiento para la preparacion de nuevas 4(3h)-piri-midonas 2,5 disustituidas

Country Status (36)

Country Link
US (1) US4772704A (es)
JP (1) JPH0643310B2 (es)
KR (1) KR900001198B1 (es)
AR (2) AR242385A1 (es)
AT (1) AT387965B (es)
AU (1) AU583479B2 (es)
BE (1) BE900652A (es)
CA (1) CA1260463A (es)
CH (1) CH665840A5 (es)
CS (1) CS249147B2 (es)
CY (1) CY1561A (es)
DD (1) DD226881A5 (es)
DE (1) DE3434578A1 (es)
DK (1) DK162987C (es)
ES (4) ES8607253A1 (es)
FI (1) FI83868C (es)
FR (1) FR2552082B1 (es)
GB (1) GB2146994B (es)
GR (1) GR80439B (es)
HK (1) HK73790A (es)
HU (1) HU193227B (es)
IE (1) IE58083B1 (es)
IL (1) IL72990A (es)
IT (1) IT1176739B (es)
LU (1) LU85550A1 (es)
NL (1) NL8402898A (es)
NO (1) NO161561C (es)
NZ (1) NZ209572A (es)
OA (1) OA07820A (es)
PT (1) PT79256B (es)
SE (1) SE463209B (es)
SG (1) SG60890G (es)
YU (1) YU45205B (es)
ZA (1) ZA847345B (es)
ZM (1) ZM4984A1 (es)
ZW (1) ZW16084A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質tan―1057,その製造法および用途
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
ES477520A1 (es) * 1978-02-25 1979-06-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevas penicilinas.
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
AU531142B2 (en) * 1979-04-04 1983-08-11 Smith Kline & French Laboratories Limited 2 amino- pyimindones
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
US4352933A (en) * 1981-02-06 1982-10-05 Smithkline Beckman Corporation Chemical methods and intermediates for preparing substituted pyrimidinones
US4468399A (en) * 1981-12-28 1984-08-28 Eli Lilly And Company 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
CA1275097A (en) * 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives

Also Published As

Publication number Publication date
BE900652A (fr) 1985-03-21
IT1176739B (it) 1987-08-18
IL72990A (en) 1990-07-12
CH665840A5 (de) 1988-06-15
DK162987C (da) 1992-06-01
OA07820A (fr) 1986-11-20
NZ209572A (en) 1988-05-30
ES551500A0 (es) 1987-03-16
ES551501A0 (es) 1987-01-16
IT8422744A1 (it) 1986-03-20
DK450484A (da) 1985-03-22
NO161561C (no) 1989-08-30
AT387965B (de) 1989-04-10
NO843726L (no) 1985-03-22
KR900001198B1 (ko) 1990-02-28
PT79256B (en) 1986-11-20
CS249147B2 (en) 1987-03-12
ZM4984A1 (en) 1985-05-21
JPH0643310B2 (ja) 1994-06-08
GB8423863D0 (en) 1984-10-24
ZA847345B (en) 1985-06-26
DD226881A5 (de) 1985-09-04
IE58083B1 (en) 1993-06-30
FI843643A0 (fi) 1984-09-18
NL8402898A (nl) 1985-04-16
HK73790A (en) 1990-09-28
FI83868B (fi) 1991-05-31
ZW16084A1 (en) 1985-01-16
PT79256A (en) 1984-10-01
CA1260463A (en) 1989-09-26
US4772704A (en) 1988-09-20
GR80439B (en) 1985-01-22
DK162987B (da) 1992-01-06
ATA300984A (de) 1988-09-15
SE8404729L (sv) 1985-03-22
SE8404729D0 (sv) 1984-09-20
GB2146994B (en) 1987-09-03
ES8702897A1 (es) 1987-01-16
SE463209B (sv) 1990-10-22
ES536054A0 (es) 1986-05-16
FR2552082A1 (fr) 1985-03-22
IE842406L (en) 1985-03-21
AU583479B2 (en) 1989-05-04
ES8704155A1 (es) 1987-03-16
KR850002259A (ko) 1985-05-10
GB2146994A (en) 1985-05-01
AU3335184A (en) 1985-03-28
AR242789A1 (es) 1993-05-31
JPS6087271A (ja) 1985-05-16
SG60890G (en) 1990-09-07
LU85550A1 (fr) 1985-06-04
YU45205B (en) 1992-05-28
DE3434578A1 (de) 1985-04-11
CY1561A (en) 1991-03-22
DK450484D0 (da) 1984-09-20
HUT35259A (en) 1985-06-28
NO161561B (no) 1989-05-22
HU193227B (en) 1987-08-28
FI843643L (fi) 1985-03-22
FI83868C (fi) 1991-09-10
YU161384A (en) 1987-12-31
ES8607253A1 (es) 1986-05-16
ES8704465A1 (es) 1987-04-01
AR242385A1 (es) 1993-03-31
FR2552082B1 (fr) 1987-02-20
IT8422744A0 (it) 1984-09-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612