YU45205B - Process for obtaining 2,5 disubstituted-4 (3h)-pyrimidones - Google Patents

Process for obtaining 2,5 disubstituted-4 (3h)-pyrimidones

Info

Publication number
YU45205B
YU45205B YU1613/84A YU161384A YU45205B YU 45205 B YU45205 B YU 45205B YU 1613/84 A YU1613/84 A YU 1613/84A YU 161384 A YU161384 A YU 161384A YU 45205 B YU45205 B YU 45205B
Authority
YU
Yugoslavia
Prior art keywords
pyrimidones
disubstituted
obtaining
Prior art date
Application number
YU1613/84A
Other languages
English (en)
Other versions
YU161384A (en
Inventor
A A Algieri
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to YU206786A priority Critical patent/YU45386B/xx
Publication of YU161384A publication Critical patent/YU161384A/xx
Publication of YU45205B publication Critical patent/YU45205B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YU1613/84A 1983-09-21 1984-09-19 Process for obtaining 2,5 disubstituted-4 (3h)-pyrimidones YU45205B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU206786A YU45386B (en) 1983-09-21 1986-12-03 Process for obtaining 2,5 disubstituted-4 (3h)-pyrimidones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/534,426 US4772704A (en) 1983-09-21 1983-09-21 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity

Publications (2)

Publication Number Publication Date
YU161384A YU161384A (en) 1987-12-31
YU45205B true YU45205B (en) 1992-05-28

Family

ID=24129972

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1613/84A YU45205B (en) 1983-09-21 1984-09-19 Process for obtaining 2,5 disubstituted-4 (3h)-pyrimidones

Country Status (36)

Country Link
US (1) US4772704A (xx)
JP (1) JPH0643310B2 (xx)
KR (1) KR900001198B1 (xx)
AR (2) AR242385A1 (xx)
AT (1) AT387965B (xx)
AU (1) AU583479B2 (xx)
BE (1) BE900652A (xx)
CA (1) CA1260463A (xx)
CH (1) CH665840A5 (xx)
CS (1) CS249147B2 (xx)
CY (1) CY1561A (xx)
DD (1) DD226881A5 (xx)
DE (1) DE3434578A1 (xx)
DK (1) DK162987C (xx)
ES (4) ES8607253A1 (xx)
FI (1) FI83868C (xx)
FR (1) FR2552082B1 (xx)
GB (1) GB2146994B (xx)
GR (1) GR80439B (xx)
HK (1) HK73790A (xx)
HU (1) HU193227B (xx)
IE (1) IE58083B1 (xx)
IL (1) IL72990A (xx)
IT (1) IT1176739B (xx)
LU (1) LU85550A1 (xx)
NL (1) NL8402898A (xx)
NO (1) NO161561C (xx)
NZ (1) NZ209572A (xx)
OA (1) OA07820A (xx)
PT (1) PT79256B (xx)
SE (1) SE463209B (xx)
SG (1) SG60890G (xx)
YU (1) YU45205B (xx)
ZA (1) ZA847345B (xx)
ZM (1) ZM4984A1 (xx)
ZW (1) ZW16084A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (xx) * 1978-02-13 1983-03-05 Smith Kline French Lab
ES477520A1 (es) * 1978-02-25 1979-06-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevas penicilinas.
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
AU531142B2 (en) * 1979-04-04 1983-08-11 Smith Kline & French Laboratories Limited 2 amino- pyimindones
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
US4352933A (en) * 1981-02-06 1982-10-05 Smithkline Beckman Corporation Chemical methods and intermediates for preparing substituted pyrimidinones
US4468399A (en) * 1981-12-28 1984-08-28 Eli Lilly And Company 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
CA1275097A (en) * 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives

Also Published As

Publication number Publication date
NZ209572A (en) 1988-05-30
DK162987B (da) 1992-01-06
AT387965B (de) 1989-04-10
CS249147B2 (en) 1987-03-12
ES551501A0 (es) 1987-01-16
GB2146994B (en) 1987-09-03
PT79256B (en) 1986-11-20
HK73790A (en) 1990-09-28
DE3434578A1 (de) 1985-04-11
DK450484D0 (da) 1984-09-20
AR242385A1 (es) 1993-03-31
KR850002259A (ko) 1985-05-10
NO843726L (no) 1985-03-22
AR242789A1 (es) 1993-05-31
NO161561C (no) 1989-08-30
ES544213A0 (es) 1987-04-01
ES8607253A1 (es) 1986-05-16
SG60890G (en) 1990-09-07
FI843643A0 (fi) 1984-09-18
FR2552082A1 (fr) 1985-03-22
FI83868B (fi) 1991-05-31
ES8704155A1 (es) 1987-03-16
DK162987C (da) 1992-06-01
ES8704465A1 (es) 1987-04-01
CY1561A (en) 1991-03-22
IT1176739B (it) 1987-08-18
FI83868C (fi) 1991-09-10
IT8422744A0 (it) 1984-09-20
NL8402898A (nl) 1985-04-16
IT8422744A1 (it) 1986-03-20
IE842406L (en) 1985-03-21
CA1260463A (en) 1989-09-26
KR900001198B1 (ko) 1990-02-28
LU85550A1 (fr) 1985-06-04
ES8702897A1 (es) 1987-01-16
HU193227B (en) 1987-08-28
US4772704A (en) 1988-09-20
CH665840A5 (de) 1988-06-15
ES551500A0 (es) 1987-03-16
DD226881A5 (de) 1985-09-04
SE463209B (sv) 1990-10-22
AU583479B2 (en) 1989-05-04
ATA300984A (de) 1988-09-15
NO161561B (no) 1989-05-22
GB2146994A (en) 1985-05-01
ES536054A0 (es) 1986-05-16
HUT35259A (en) 1985-06-28
AU3335184A (en) 1985-03-28
SE8404729D0 (sv) 1984-09-20
ZW16084A1 (en) 1985-01-16
DK450484A (da) 1985-03-22
PT79256A (en) 1984-10-01
FI843643L (fi) 1985-03-22
OA07820A (fr) 1986-11-20
ZA847345B (en) 1985-06-26
JPS6087271A (ja) 1985-05-16
SE8404729L (sv) 1985-03-22
BE900652A (fr) 1985-03-21
FR2552082B1 (fr) 1987-02-20
GR80439B (en) 1985-01-22
GB8423863D0 (en) 1984-10-24
IL72990A (en) 1990-07-12
YU161384A (en) 1987-12-31
ZM4984A1 (en) 1985-05-21
IE58083B1 (en) 1993-06-30
JPH0643310B2 (ja) 1994-06-08

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