ZA991551B - 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines. - Google Patents

6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines.

Info

Publication number
ZA991551B
ZA991551B ZA9901551A ZA991551A ZA991551B ZA 991551 B ZA991551 B ZA 991551B ZA 9901551 A ZA9901551 A ZA 9901551A ZA 991551 A ZA991551 A ZA 991551A ZA 991551 B ZA991551 B ZA 991551B
Authority
ZA
South Africa
Prior art keywords
aminocyclohexyl
purines
disubstituted
trans
amino
Prior art date
Application number
ZA9901551A
Other languages
English (en)
Inventor
Jennifer A Dumont
David R Borcherding
H Randall Munson
Alan J Bitonti
Norton P Peet
Patrick W K Shum
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA991551B publication Critical patent/ZA991551B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9901551A 1998-02-26 1999-02-25 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines. ZA991551B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13510998P 1998-02-26 1998-02-26
US3097598A 1998-02-26 1998-02-26
US09/247,053 US6479487B1 (en) 1998-02-26 1999-02-09 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines

Publications (1)

Publication Number Publication Date
ZA991551B true ZA991551B (en) 1999-08-26

Family

ID=27363758

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9901551A ZA991551B (en) 1998-02-26 1999-02-25 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines.

Country Status (17)

Country Link
US (1) US6479487B1 (zh)
EP (1) EP1056744B1 (zh)
JP (1) JP2002504552A (zh)
CN (1) CN1143858C (zh)
AP (1) AP1054A (zh)
AU (1) AU747151B2 (zh)
BR (1) BR9909256A (zh)
CA (1) CA2320474C (zh)
EE (1) EE04815B1 (zh)
HU (1) HUP0100889A3 (zh)
IL (1) IL138043A0 (zh)
NO (1) NO328509B1 (zh)
PL (1) PL194174B1 (zh)
SK (1) SK12902000A3 (zh)
TR (1) TR200002463T2 (zh)
WO (1) WO1999043675A1 (zh)
ZA (1) ZA991551B (zh)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642231B2 (en) * 1998-02-26 2003-11-04 Aventis Pharmaceuticals Inc. 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6969720B2 (en) * 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
MXPA03001189A (es) 2000-08-09 2004-05-14 Agouron Pharma Compuestos de pirazol-tiazol, composiciones farmaceuticas que los contienen y su uso para inhibir las cinasas dependientes de ciclinas.
BR0113258A (pt) 2000-08-18 2003-07-15 Agouron Pharma Compostos, pró-drogas, metabólitos ou sais, métodos de tratamento de condição doentia em mamìferos, mediada pela atividade de proteìna cinase e métodos de modulação ou inibição da atividade de um receptor de proteìna cinase
AU3938802A (en) * 2000-10-31 2002-06-03 Aventis Pharma Inc Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
JP2006514646A (ja) * 2002-12-13 2006-05-11 スミスクライン ビーチャム コーポレーション Ｃｃｒ５アンタゴニストとしてのシクロヘキシル化合物類
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
KR100677396B1 (ko) * 2004-11-20 2007-02-02 엘지전자 주식회사 음성인식장치의 음성구간 검출방법
AR077280A1 (es) 2009-06-29 2011-08-17 Incyte Corp Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden
US8759359B2 (en) * 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
WO2011163195A1 (en) 2010-06-21 2011-12-29 Incyte Corporation Fused pyrrole derivatives as pi3k inhibitors
CA2822070C (en) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CN102898356B (zh) * 2011-07-29 2015-08-26 上海医药工业研究院 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法
DK2751109T3 (en) 2011-09-02 2017-01-23 Incyte Holdings Corp HETEROCYCLYLAMINES AS PI3K INHIBITORS
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
CN103193699B (zh) * 2013-04-18 2015-04-15 安徽赛诺医药化工有限公司 一种制备普卡必利中间体的新方法
CN103508939A (zh) * 2013-06-30 2014-01-15 北京万全德众医药生物技术有限公司 一种制备普卡必利中间体1-（3-甲氧基丙基）-4-哌啶胺的方法
CN103848777B (zh) * 2014-03-18 2016-04-13 悦康药业集团有限公司 一种n-(3-甲氧基丙基)-4-氨基哌啶的合成方法
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
TWI748941B (zh) 2015-02-27 2021-12-11 美商英塞特公司 Ｐｉ３ｋ抑制劑之鹽及製備方法
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
TWI703150B (zh) 2015-06-04 2020-09-01 美商庫拉腫瘤技術股份有限公司 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
CN114539284A (zh) 2016-03-16 2022-05-27 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
CN109640987B (zh) 2016-03-16 2022-12-02 库拉肿瘤学公司 Menin-mll的桥联双环抑制剂及使用方法
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
US11944627B2 (en) 2017-03-24 2024-04-02 Kura Oncology, Inc. Methods for treating hematological malignancies and Ewing's sarcoma
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
CN115677567A (zh) * 2022-11-15 2023-02-03 大唐环境产业集团股份有限公司 一种4-氨基-1-哌啶丙醇的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232155A (en) 1979-09-13 1980-11-04 Bristol-Myers Company Purine compounds
DE69032841T2 (de) * 1989-01-23 1999-05-12 Chiron Corp., Emeryville, Calif. Rekombinante zellen für therapien von infektionen und hyperprolieferative störungen und deren herstellung
CA2084222C (en) 1991-12-06 2004-04-06 David R. Borcherding Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5516631A (en) * 1992-10-13 1996-05-14 La Jolla Cancer Research Foundation Method of inhibiting replication of hyperproliferative cells
GB9301000D0 (en) 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
US5688665A (en) * 1994-01-07 1997-11-18 Fred Hutchinson Cancer Research Center Isolated nucleic acid molecules encoding the p27 KIP-1 protein
GB9414208D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
ES2196181T3 (es) 1995-11-01 2003-12-16 Novartis Ag Derivados de purina y proceso para su preparacion.
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6255485B1 (en) 1997-08-07 2001-07-03 The Regents Of The University Of California Purine inhibitors of protein kinases, G proteins and polymerases
RU2001124352A (ru) 1999-02-01 2004-02-20 Си Ви Терапьютикс, Инк. (Us) Пуриновые ингибиторы циклин-зависимой киназы 2 и Ikb-альфа
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Also Published As

Publication number Publication date
CN1292789A (zh) 2001-04-25
AU747151B2 (en) 2002-05-09
CA2320474A1 (en) 1999-09-02
PL194174B1 (pl) 2007-05-31
EE200000489A (et) 2002-04-15
US6479487B1 (en) 2002-11-12
EE04815B1 (et) 2007-04-16
IL138043A0 (en) 2001-10-31
AP1054A (en) 2002-04-01
CN1143858C (zh) 2004-03-31
JP2002504552A (ja) 2002-02-12
EP1056744B1 (en) 2003-10-22
TR200002463T2 (tr) 2000-12-21
WO1999043675A1 (en) 1999-09-02
SK12902000A3 (sk) 2001-04-09
NO328509B1 (no) 2010-03-08
AU2770999A (en) 1999-09-15
PL342604A1 (en) 2001-06-18
HUP0100889A2 (hu) 2002-01-28
HUP0100889A3 (en) 2003-07-28
EP1056744A1 (en) 2000-12-06
NO20004280L (no) 2000-10-25
CA2320474C (en) 2005-05-10
NO20004280D0 (no) 2000-08-25
AP2000001922A0 (en) 2000-09-30
BR9909256A (pt) 2000-11-28

Similar Documents

Publication Publication Date Title
ZA991551B (en) 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines.
ZA991548B (en) 6,9-Disubstituted 2-[trans-(4-Aminocyclohexyl) Amino] Purines.
SG71077A1 (en) 8-Substituted-1,3, 8-triaza-spiro (4.5)decan-4-on derivatives
HK1061852A1 (en) 4,5-dihydro-ih-pyrazole derivatives having cb1-antagonistic activity
PL337057A1 (en) 2-substituted 4,5-diarylimidazoles
NO983244D0 (no) 5H-Tiazolo £3,2-a| pyrimidinderivater
ZA981017B (en) 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines.
TR199802520A3 (tr) 1,3,8-Triaza-spiro(4,5) dekan -4-on türevleri.
ZA99569B (en) 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3 hydroxyamic acids.
ATE234302T1 (de) Di- oder triazaspiro(4,5)decanderivate
AU2964899A (en) 2,4-dioxo-5-arylidenimino-1,3-pyrimidines
AU6838498A (en) 6,6'-bis-(1-phosphanorbornadiene) diphosphines
HK1030949A1 (en) 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines
MXPA03007242A (es) Delta-1-pirrolinas para control de pestes.
ZA984592B (en) Herbicidal 3,5-difluoropyridines.
SI1056744T1 (en) 6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines
ZA973732B (en) Arm rest.
AU2002258620A1 (en) (oxo-pyrazolo(1,5a)pyrimidin-2-yl)alkyl-carboxamides
AUPR254801A0 (en) F.l.o.e.s; s.p.l.s.d(1); c.r.b.r.w.s.s
AUPP804299A0 (en) C.2000