ZA988285B - 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles process for their preparation and their use for medicaments - Google Patents

1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles process for their preparation and their use for medicaments

Info

Publication number
ZA988285B
ZA988285B ZA988285A ZA988285A ZA988285B ZA 988285 B ZA988285 B ZA 988285B ZA 988285 A ZA988285 A ZA 988285A ZA 988285 A ZA988285 A ZA 988285A ZA 988285 B ZA988285 B ZA 988285B
Authority
ZA
South Africa
Prior art keywords
benzazocin
oles
methano
hexahydro
medicaments
Prior art date
Application number
ZA988285A
Other languages
English (en)
Inventor
Matthias Grauert
Andrian Carter
Wolf-Dietrich Bechtel
Thomas Weiser
Rainer Palluk
Uwe Pschorn
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ZA988285B publication Critical patent/ZA988285B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
ZA988285A 1997-09-12 1998-09-10 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles process for their preparation and their use for medicaments ZA988285B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19740110A DE19740110A1 (de) 1997-09-12 1997-09-12 Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ZA988285B true ZA988285B (en) 1999-03-12

Family

ID=7842134

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA988285A ZA988285B (en) 1997-09-12 1998-09-10 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles process for their preparation and their use for medicaments

Country Status (38)

Country Link
US (1) US6455538B1 (tr)
EP (1) EP1015433B1 (tr)
JP (1) JP3827528B2 (tr)
KR (1) KR100601008B1 (tr)
CN (1) CN1166640C (tr)
AR (1) AR017095A1 (tr)
AT (1) ATE267811T1 (tr)
AU (1) AU751036B2 (tr)
BG (1) BG64418B1 (tr)
BR (1) BR9812443A (tr)
CA (1) CA2302347C (tr)
CO (1) CO5011117A1 (tr)
CZ (1) CZ296909B6 (tr)
DE (2) DE19740110A1 (tr)
DK (1) DK1015433T3 (tr)
EE (1) EE04398B1 (tr)
ES (1) ES2222612T3 (tr)
HR (1) HRP980502B1 (tr)
HU (1) HUP0004588A3 (tr)
ID (1) ID24173A (tr)
IL (1) IL134572A (tr)
MY (1) MY120550A (tr)
NO (1) NO315650B1 (tr)
NZ (1) NZ503710A (tr)
PE (1) PE122899A1 (tr)
PL (1) PL198486B1 (tr)
PT (1) PT1015433E (tr)
RS (1) RS49888B (tr)
RU (1) RU2218334C2 (tr)
SA (1) SA98190765B1 (tr)
SK (1) SK284670B6 (tr)
TR (1) TR200000697T2 (tr)
TW (1) TW505645B (tr)
UA (1) UA61973C2 (tr)
UY (2) UY25175A1 (tr)
WO (1) WO1999014199A1 (tr)
YU (1) YU12000A (tr)
ZA (1) ZA988285B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6683089B2 (en) 2002-02-02 2004-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
DE10223783A1 (de) * 2002-05-29 2003-12-11 Boehringer Ingelheim Pharma Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers
US6828311B2 (en) 2002-05-29 2004-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Formulation for the parenteral application of a sodium channel blocker
US20040019075A1 (en) * 2002-05-29 2004-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New formulation for the parenteral application of crobenetine
US20030235576A1 (en) * 2002-06-15 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of ischaemic conditions
DE10226814A1 (de) * 2002-06-15 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände
NZ567540A (en) 2005-12-22 2010-07-30 Newron Pharm Spa 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators
DK2155663T3 (en) 2007-06-15 2018-01-22 Newron Pharm Spa SUBSTITUTED 2- [2- (PHENYL) ETHYLAMINO] ALKANAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND / OR CALCIUM CHANNEL MODULATORS
HUE030031T2 (en) 2011-06-27 2017-04-28 Newron Pharm Spa Fluorinated arylalkylaminocarboxamide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en) 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de) 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
ID24173A (id) 2000-07-13
EE200000129A (et) 2001-02-15
CN1166640C (zh) 2004-09-15
NO315650B1 (no) 2003-10-06
JP3827528B2 (ja) 2006-09-27
HUP0004588A3 (en) 2002-10-28
UA61973C2 (en) 2003-12-15
HRP980502A2 (en) 1999-06-30
ES2222612T3 (es) 2005-02-01
BR9812443A (pt) 2000-09-26
DK1015433T3 (da) 2004-09-27
CO5011117A1 (es) 2001-02-28
PL198486B1 (pl) 2008-06-30
NO20001288D0 (no) 2000-03-10
CZ296909B6 (cs) 2006-07-12
UY25175A1 (es) 2000-12-29
CA2302347A1 (en) 1999-03-25
BG64418B1 (bg) 2005-01-31
SK3342000A3 (en) 2000-09-12
RS49888B (sr) 2008-08-07
CA2302347C (en) 2008-06-17
RU2218334C2 (ru) 2003-12-10
SK284670B6 (sk) 2005-08-04
AU9624298A (en) 1999-04-05
IL134572A0 (en) 2001-04-30
MY120550A (en) 2005-11-30
CN1269790A (zh) 2000-10-11
ATE267811T1 (de) 2004-06-15
KR100601008B1 (ko) 2006-07-19
AR017095A1 (es) 2001-08-22
TR200000697T2 (tr) 2001-01-22
JP2001516747A (ja) 2001-10-02
WO1999014199A1 (de) 1999-03-25
DE59811477D1 (de) 2004-07-01
HRP980502B1 (en) 2005-02-28
PE122899A1 (es) 1999-12-06
PT1015433E (pt) 2004-08-31
IL134572A (en) 2005-05-17
NO20001288L (no) 2000-03-13
SA98190765B1 (ar) 2006-06-10
PL339061A1 (en) 2000-12-04
TW505645B (en) 2002-10-11
EE04398B1 (et) 2004-12-15
DE19740110A1 (de) 1999-03-18
YU12000A (sh) 2002-11-15
BG104232A (en) 2000-10-31
CZ2000894A3 (cs) 2000-09-13
HUP0004588A2 (hu) 2001-07-30
KR20010023879A (ko) 2001-03-26
EP1015433A1 (de) 2000-07-05
UY25439A1 (es) 1999-11-17
US6455538B1 (en) 2002-09-24
NZ503710A (en) 2002-04-26
EP1015433B1 (de) 2004-05-26
AU751036B2 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
NZ314419A (en) Substituted 2,4-aryl-3-hydroxyalkyl pyridines; preparation and medicaments
NZ329176A (en) 2,5-dioxo-imidazolidine derivatives and medicaments
AP9901556A0 (en) Sulpponamide derivatives process for their preparation and their use as medicaments
EP0710667A3 (de) Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
AP9500744A0 (en) New erythromycin derivatives, their process and their use as medicaments
IL112954A0 (en) New erythromycin derivatives, their preparation process and their use as medicaments
HUP9800138A3 (en) 8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives, process for producing them, pharmaceutical compositions containing the same and their use
IL129315A0 (en) Oxadiazoles process for their preparation and their use as medicaments
IL126787A (en) D-proline derivatives, medicaments against amyloidosis comprising them and a process for their preparation
SI1019358T2 (sl) 3,3-diarilpropilamini, njihova uporaba in priprava
HUP0000426A3 (en) Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation
HUP9800555A3 (en) 3,3-diphenylallylamine derivatives and process for their preparation
HU9501086D0 (en) Organoaluminoxy product, preparation and use
HUP9802807A3 (en) 1,3,8-triazo-spiro[4,5]decan-4-on derivatives, their use, production thereof and medicaments containing the same
HK1040980A1 (zh) 聯苯磺酰基氨基氰、其製備方法及其作為藥物的用途
ZA988285B (en) 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles process for their preparation and their use for medicaments
IL118485A (en) 5,6-dihydro-9H-pyrazolo¬3,4-c¾-1,2,4-triazolo¬4,3-a¾ pyridines and pharmaceutical compositions containing them
ZA958161B (en) Process for preparing 1,3-alkanediols and 3-hydroxyaldehydes
HK1010885A1 (en) 10,13,15-trioxatricyclo [9.2.1.1.9.6]-pentadecanone-derivatives, process for their preparation and pharmaceutical containing them
HUP9602868A3 (en) 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
ZA958160B (en) Process for preparing 1,3-alkanediols and 3-hydroxyaldehydes
HUP0104620A3 (en) 2-phenylpyran-4-one derivatives, process for their preparation and medicaments containing them
AU3011095A (en) 2,3-bridged 1,4-dihydropyridines, processes for their preparation and their use as medicaments
HUP9600665A2 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
SI0863139T1 (en) Benzoxazindione derivatives, process for their preparation and their use