ZA986786B - 4-oxo-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide-derivatives their preparation and their application in therapeutics - Google Patents

4-oxo-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide-derivatives their preparation and their application in therapeutics

Info

Publication number
ZA986786B
ZA986786B ZA986786A ZA986786A ZA986786B ZA 986786 B ZA986786 B ZA 986786B ZA 986786 A ZA986786 A ZA 986786A ZA 986786 A ZA986786 A ZA 986786A ZA 986786 B ZA986786 B ZA 986786B
Authority
ZA
South Africa
Prior art keywords
pyridazino
acetamide
therapeutics
indole
dihydro
Prior art date
Application number
ZA986786A
Other languages
English (en)
Inventor
Yannick Evanno
Laurent Dubois
Mireille Sevrin
Frank Marguet
Jacques Froissant
Regine Bartsch
Catherine Gille
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA986786B publication Critical patent/ZA986786B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA986786A 1997-07-30 1998-07-29 4-oxo-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide-derivatives their preparation and their application in therapeutics ZA986786B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ZA986786B true ZA986786B (en) 1999-02-02

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA986786A ZA986786B (en) 1997-07-30 1998-07-29 4-oxo-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide-derivatives their preparation and their application in therapeutics

Country Status (33)

Country Link
US (1) US6262045B1 (ko)
EP (1) EP1000063B1 (ko)
JP (1) JP4322421B2 (ko)
KR (1) KR100497782B1 (ko)
CN (1) CN1134440C (ko)
AR (1) AR013264A1 (ko)
AT (1) ATE226584T1 (ko)
AU (1) AU736600B2 (ko)
BG (1) BG64283B1 (ko)
BR (1) BR9811582B1 (ko)
CA (1) CA2298522C (ko)
CO (1) CO5210883A1 (ko)
CZ (1) CZ290011B6 (ko)
DE (1) DE69808921T2 (ko)
DK (1) DK1000063T3 (ko)
EE (1) EE04317B1 (ko)
ES (1) ES2186212T3 (ko)
FR (1) FR2766823B1 (ko)
HK (1) HK1028027A1 (ko)
HU (1) HU229430B1 (ko)
IL (1) IL133633A (ko)
NO (1) NO313963B1 (ko)
NZ (1) NZ502361A (ko)
PL (1) PL194245B1 (ko)
PT (1) PT1000063E (ko)
RU (1) RU2197490C2 (ko)
SI (1) SI1000063T1 (ko)
SK (1) SK283075B6 (ko)
TR (1) TR200000278T2 (ko)
TW (1) TW506971B (ko)
UA (1) UA57088C2 (ko)
WO (1) WO1999006406A1 (ko)
ZA (1) ZA986786B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
JP5483874B2 (ja) * 2005-05-05 2014-05-07 サノフィ−アベンティス・ユー・エス・エルエルシー 安定なナノ粒子処方物
NZ566313A (en) * 2005-08-29 2011-04-29 Sanofi Aventis Us Llc Amorphous solid dispersions of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4, 5-b]indole-1-acetamide
PT1924585E (pt) * 2005-08-29 2012-01-19 Sanofi Aventis Us Llc Nova forma cristalina de um derivado de piridazino[4,5-b]indole
MX2008004024A (es) * 2005-09-23 2009-02-27 Schering Corp Antagonistas de receptor de glutamato metabotropico-1 tetraciclicos fusionados como agentes terapeuticos.
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
AU2009283039A1 (en) * 2008-08-18 2010-02-25 Sanofi-Aventis U.S. Llc Process for preparing polymorph of 7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4H-pyridazin0[4,5-b]indole-1-acetamide
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP2001512122A (ja) 2001-08-21
BR9811582B1 (pt) 2010-10-19
EE04317B1 (et) 2004-06-15
TR200000278T2 (tr) 2000-08-21
DK1000063T3 (da) 2003-02-24
KR100497782B1 (ko) 2005-06-27
SK1292000A3 (en) 2000-08-14
CA2298522C (en) 2008-07-15
NZ502361A (en) 2001-06-29
PL194245B1 (pl) 2007-05-31
NO20000462D0 (no) 2000-01-28
SI1000063T1 (en) 2003-04-30
IL133633A (en) 2004-02-08
HUP0002650A2 (hu) 2001-01-29
US6262045B1 (en) 2001-07-17
ES2186212T3 (es) 2003-05-01
TW506971B (en) 2002-10-21
CA2298522A1 (en) 1999-02-11
HK1028027A1 (en) 2001-02-02
ATE226584T1 (de) 2002-11-15
AR013264A1 (es) 2000-12-13
CN1134440C (zh) 2004-01-14
UA57088C2 (uk) 2003-06-16
SK283075B6 (sk) 2003-02-04
AU8983298A (en) 1999-02-22
CO5210883A1 (es) 2002-10-30
CZ2000320A3 (cs) 2000-05-17
JP4322421B2 (ja) 2009-09-02
DE69808921D1 (de) 2002-11-28
NO313963B1 (no) 2003-01-06
BR9811582A (pt) 2000-09-26
BG104096A (en) 2000-08-31
HU229430B1 (en) 2013-12-30
WO1999006406A1 (fr) 1999-02-11
FR2766823A1 (fr) 1999-02-05
EP1000063B1 (fr) 2002-10-23
AU736600B2 (en) 2001-08-02
KR20010022356A (ko) 2001-03-15
EP1000063A1 (fr) 2000-05-17
FR2766823B1 (fr) 1999-10-08
CZ290011B6 (cs) 2002-05-15
HUP0002650A3 (en) 2002-09-30
PT1000063E (pt) 2003-03-31
DE69808921T2 (de) 2003-07-03
BG64283B1 (bg) 2004-08-31
IL133633A0 (en) 2001-04-30
RU2197490C2 (ru) 2003-01-27
NO20000462L (no) 2000-03-29
PL338445A1 (en) 2000-11-06
CN1265108A (zh) 2000-08-30
EE200000056A (et) 2000-10-16

Similar Documents

Publication Publication Date Title
IL139787A0 (en) PYRROLO [2, 3d] PYRIMIDINE COMPOSITIONS AND THEIR USE
IL111148A0 (en) Imidazol-4- ylpiperidine derivatives, their preparation and their application in therapeutics
IL120124A0 (en) Heteroaryl-oxazolidinones their preparation and use
SI1019358T2 (sl) 3,3-diarilpropilamini, njihova uporaba in priprava
ZA986786B (en) 4-oxo-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide-derivatives their preparation and their application in therapeutics
CY2291B1 (en) 1H-pyridoa3,4-buindole-4-carboxamide derivatives preparation and application thereof in therapeutics
ZA988921B (en) 3,4-diarylthiazolin-2-one or -2-thione derivatives their methods of preparation and their uses in therapeutics
ZA978089B (en) 3,4-diaryloxazolone derivatives, their methods of preparation, and their use in therapeutics.
IL118644A (en) N-¬(1,4-diazabicyclo¬2.2.2¾oct-2-YL)methyl¾benzamide derivatives their preparation and their application in therapeutics
IL131645A (en) Pyrimido ¬1,2-a¾indole derivatives and their preparation
ZA982365B (en) 2, 3-dihydrofuro[3,2-b]pyridine derivatives their preparation and their application in therapeutics
ZA972894B (en) Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics.
HUP9904091A3 (en) N-(benzothiazol-2-yl) piperidine-1-ethanamine derivatives, their preparation and application in therapeutics
ZA977767B (en) Benzylamine derivatives, their preparation and their application in therapeutics.
ZA982369B (en) Dihydropyrazino[1,2-a]indol-1-one derivatives their preparation and their use in therapy
IL133536A0 (en) 6-pyrrolidin-2-ylpyridine derivatives, their preparation and application in therapy
ZA982358B (en) Benzenesulphonamide derivatives their preparation and their application in therapeutics
ZA976828B (en) 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine-3-acetic acid derivatives, their preparation and their application in therapy.
ZA967558B (en) Alpha-phenylpiperidine-1-propanol derivatives their preparation and their application in therapeutics
SG64479A1 (en) Reactive dyes their preparation and use
IL129546A0 (en) N-(imidazolylbutyl)benzenesulphonamide derivatives their preparation and their application in therapeutics
GB2323275B (en) Improvements in chairs
GB9721604D0 (en) Improvements in or relating to chairs
IL113150A0 (en) 1,2,4-triazolo [4,3-a]pyrazin-4-one derivatives and preparation thereof
HUP0104267A3 (en) 1,4-diaryl-2-fluoro-1-buten-3-ol compounds and their use in the preparation of 1,4-diaryl-2-fluoro-1,3-butadiane and 1,4-diaryl-2-fluoro-2-butene compounds