ZA985778B - Inhibitors of farnesyl protein transferase. - Google Patents

Inhibitors of farnesyl protein transferase.

Info

Publication number
ZA985778B
ZA985778B ZA9805778A ZA985778A ZA985778B ZA 985778 B ZA985778 B ZA 985778B ZA 9805778 A ZA9805778 A ZA 9805778A ZA 985778 A ZA985778 A ZA 985778A ZA 985778 B ZA985778 B ZA 985778B
Authority
ZA
South Africa
Prior art keywords
inhibitors
protein transferase
farnesyl protein
farnesyl
transferase
Prior art date
Application number
ZA9805778A
Other languages
English (en)
Inventor
Rajeev S Bhide
Charles Z Ding
John T Hunt
Soong-Hoon Kim
Katerina Leftheris
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA985778B publication Critical patent/ZA985778B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9805778A 1997-07-02 1998-07-01 Inhibitors of farnesyl protein transferase. ZA985778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5159497P 1997-07-02 1997-07-02

Publications (1)

Publication Number Publication Date
ZA985778B true ZA985778B (en) 2000-01-20

Family

ID=21972255

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9805778A ZA985778B (en) 1997-07-02 1998-07-01 Inhibitors of farnesyl protein transferase.

Country Status (24)

Country Link
US (2) US6387926B1 (hu)
EP (1) EP0994856A4 (hu)
JP (1) JP2002507989A (hu)
KR (1) KR100385941B1 (hu)
CN (1) CN1261880A (hu)
AR (1) AR016304A1 (hu)
AU (1) AU734721B2 (hu)
BR (1) BR9810465A (hu)
CA (1) CA2294530A1 (hu)
CO (1) CO4950556A1 (hu)
HU (1) HUP0004148A3 (hu)
ID (1) ID24076A (hu)
IL (1) IL133470A0 (hu)
MY (1) MY117961A (hu)
NO (1) NO316117B1 (hu)
NZ (1) NZ501293A (hu)
PE (1) PE86599A1 (hu)
PL (1) PL337697A1 (hu)
RU (1) RU2211838C2 (hu)
TR (1) TR199903331T2 (hu)
TW (1) TW527355B (hu)
UY (1) UY25074A1 (hu)
WO (1) WO1999001434A1 (hu)
ZA (1) ZA985778B (hu)

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FR2819512B1 (fr) * 2001-01-18 2003-02-21 Servier Lab Nouveaux composes cyclo[d] azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
AU2003259717A1 (en) * 2002-08-07 2004-02-25 Bristol-Myers Squibb Company Modulators of rabggt and methods of use thereof
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
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Also Published As

Publication number Publication date
PL337697A1 (en) 2000-08-28
US6387926B1 (en) 2002-05-14
CO4950556A1 (es) 2000-09-01
HUP0004148A3 (en) 2002-09-30
NZ501293A (en) 2001-10-26
UY25074A1 (es) 2000-12-29
KR100385941B1 (ko) 2003-06-09
BR9810465A (pt) 2002-04-16
TR199903331T2 (xx) 2000-06-21
EP0994856A1 (en) 2000-04-26
JP2002507989A (ja) 2002-03-12
NO996571L (no) 2000-02-23
CA2294530A1 (en) 1999-01-14
AU7971998A (en) 1999-01-25
HUP0004148A2 (hu) 2001-10-28
PE86599A1 (es) 1999-11-28
NO316117B1 (no) 2003-12-15
US6602883B1 (en) 2003-08-05
KR20010014258A (ko) 2001-02-26
TW527355B (en) 2003-04-11
ID24076A (id) 2000-07-06
NO996571D0 (no) 1999-12-30
WO1999001434A1 (en) 1999-01-14
EP0994856A4 (en) 2000-12-06
CN1261880A (zh) 2000-08-02
IL133470A0 (en) 2001-04-30
RU2211838C2 (ru) 2003-09-10
AU734721B2 (en) 2001-06-21
AR016304A1 (es) 2001-07-04
MY117961A (en) 2004-08-30

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