NO316117B1 - Inhibitorer for farnesyl-protein-transferase, anvendelse av dem og farmasöytiske preparater inneholdende dem - Google Patents
Inhibitorer for farnesyl-protein-transferase, anvendelse av dem og farmasöytiske preparater inneholdende dem Download PDFInfo
- Publication number
- NO316117B1 NO316117B1 NO19996571A NO996571A NO316117B1 NO 316117 B1 NO316117 B1 NO 316117B1 NO 19996571 A NO19996571 A NO 19996571A NO 996571 A NO996571 A NO 996571A NO 316117 B1 NO316117 B1 NO 316117B1
- Authority
- NO
- Norway
- Prior art keywords
- tetrahydro
- imidazol
- ylmethyl
- monohydroclone
- methyl
- Prior art date
Links
- 108090000992 Transferases Proteins 0.000 title claims abstract description 9
- 102000004357 Transferases Human genes 0.000 title claims abstract description 9
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title claims abstract description 7
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 13
- 239000003112 inhibitor Substances 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 173
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- -1 dihydroclone Chemical compound 0.000 claims description 50
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 36
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 35
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 34
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 22
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 17
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
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- 239000001257 hydrogen Substances 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 6
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- 102000004190 Enzymes Human genes 0.000 claims description 5
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- 125000001624 naphthyl group Chemical group 0.000 claims description 5
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- 125000000217 alkyl group Chemical group 0.000 claims description 4
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 4
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- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims 3
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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Landscapes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US5159497P | 1997-07-02 | 1997-07-02 | |
PCT/US1998/012549 WO1999001434A1 (en) | 1997-07-02 | 1998-06-16 | Inhibitors of farnesyl protein transferase |
Publications (3)
Publication Number | Publication Date |
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NO996571D0 NO996571D0 (no) | 1999-12-30 |
NO996571L NO996571L (no) | 2000-02-23 |
NO316117B1 true NO316117B1 (no) | 2003-12-15 |
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Application Number | Title | Priority Date | Filing Date |
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NO19996571A NO316117B1 (no) | 1997-07-02 | 1999-12-30 | Inhibitorer for farnesyl-protein-transferase, anvendelse av dem og farmasöytiske preparater inneholdende dem |
Country Status (24)
Country | Link |
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US (2) | US6387926B1 (hu) |
EP (1) | EP0994856A4 (hu) |
JP (1) | JP2002507989A (hu) |
KR (1) | KR100385941B1 (hu) |
CN (1) | CN1261880A (hu) |
AR (1) | AR016304A1 (hu) |
AU (1) | AU734721B2 (hu) |
BR (1) | BR9810465A (hu) |
CA (1) | CA2294530A1 (hu) |
CO (1) | CO4950556A1 (hu) |
HU (1) | HUP0004148A3 (hu) |
ID (1) | ID24076A (hu) |
IL (1) | IL133470A0 (hu) |
MY (1) | MY117961A (hu) |
NO (1) | NO316117B1 (hu) |
NZ (1) | NZ501293A (hu) |
PE (1) | PE86599A1 (hu) |
PL (1) | PL337697A1 (hu) |
RU (1) | RU2211838C2 (hu) |
TR (1) | TR199903331T2 (hu) |
TW (1) | TW527355B (hu) |
UY (1) | UY25074A1 (hu) |
WO (1) | WO1999001434A1 (hu) |
ZA (1) | ZA985778B (hu) |
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FR2819510B1 (fr) * | 2001-01-18 | 2003-10-31 | Servier Lab | Nouveaux composes cyclo[c] azepane, leur procede de preparation et les compositions pharmaceutiques qui le contiennent |
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FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
US6740757B2 (en) * | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
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BRPI0920927A2 (pt) * | 2008-11-13 | 2019-09-24 | Link Medicine Corp | derivados de azaquinolinona e usos dos mesmos |
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1998
- 1998-05-26 TW TW087108171A patent/TW527355B/zh not_active IP Right Cessation
- 1998-05-29 US US09/087,179 patent/US6387926B1/en not_active Expired - Lifetime
- 1998-06-16 BR BR9810465-9A patent/BR9810465A/pt not_active IP Right Cessation
- 1998-06-16 NZ NZ501293A patent/NZ501293A/en unknown
- 1998-06-16 TR TR1999/03331T patent/TR199903331T2/xx unknown
- 1998-06-16 EP EP98930299A patent/EP0994856A4/en not_active Withdrawn
- 1998-06-16 IL IL13347098A patent/IL133470A0/xx unknown
- 1998-06-16 HU HU0004148A patent/HUP0004148A3/hu unknown
- 1998-06-16 KR KR10-1999-7012368A patent/KR100385941B1/ko not_active IP Right Cessation
- 1998-06-16 AU AU79719/98A patent/AU734721B2/en not_active Ceased
- 1998-06-16 RU RU2000102355/04A patent/RU2211838C2/ru not_active IP Right Cessation
- 1998-06-16 CA CA002294530A patent/CA2294530A1/en not_active Abandoned
- 1998-06-16 WO PCT/US1998/012549 patent/WO1999001434A1/en not_active Application Discontinuation
- 1998-06-16 PL PL98337697A patent/PL337697A1/xx unknown
- 1998-06-16 JP JP50718899A patent/JP2002507989A/ja not_active Ceased
- 1998-06-16 CN CN98806818A patent/CN1261880A/zh active Pending
- 1998-06-26 PE PE1998000565A patent/PE86599A1/es not_active Application Discontinuation
- 1998-06-26 MY MYPI98002919A patent/MY117961A/en unknown
- 1998-06-30 UY UY25074A patent/UY25074A1/es not_active IP Right Cessation
- 1998-07-01 CO CO98037149A patent/CO4950556A1/es unknown
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- 1998-07-02 AR ARP980103223A patent/AR016304A1/es unknown
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1999
- 1999-06-16 ID IDW991728A patent/ID24076A/id unknown
- 1999-12-30 NO NO19996571A patent/NO316117B1/no unknown
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- 2000-05-05 US US09/566,396 patent/US6602883B1/en not_active Expired - Fee Related
Also Published As
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EP0994856A4 (en) | 2000-12-06 |
TR199903331T2 (xx) | 2000-06-21 |
BR9810465A (pt) | 2002-04-16 |
KR20010014258A (ko) | 2001-02-26 |
AR016304A1 (es) | 2001-07-04 |
NO996571D0 (no) | 1999-12-30 |
MY117961A (en) | 2004-08-30 |
CN1261880A (zh) | 2000-08-02 |
UY25074A1 (es) | 2000-12-29 |
HUP0004148A3 (en) | 2002-09-30 |
KR100385941B1 (ko) | 2003-06-09 |
CO4950556A1 (es) | 2000-09-01 |
PE86599A1 (es) | 1999-11-28 |
IL133470A0 (en) | 2001-04-30 |
JP2002507989A (ja) | 2002-03-12 |
US6387926B1 (en) | 2002-05-14 |
ID24076A (id) | 2000-07-06 |
HUP0004148A2 (hu) | 2001-10-28 |
EP0994856A1 (en) | 2000-04-26 |
NO996571L (no) | 2000-02-23 |
CA2294530A1 (en) | 1999-01-14 |
ZA985778B (en) | 2000-01-20 |
US6602883B1 (en) | 2003-08-05 |
RU2211838C2 (ru) | 2003-09-10 |
AU734721B2 (en) | 2001-06-21 |
TW527355B (en) | 2003-04-11 |
PL337697A1 (en) | 2000-08-28 |
AU7971998A (en) | 1999-01-25 |
NZ501293A (en) | 2001-10-26 |
WO1999001434A1 (en) | 1999-01-14 |
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