ZA985210B - Compounds for the inhibition of farnesyl protein transferase - Google Patents

Compounds for the inhibition of farnesyl protein transferase

Info

Publication number
ZA985210B
ZA985210B ZA985210A ZA985210A ZA985210B ZA 985210 B ZA985210 B ZA 985210B ZA 985210 A ZA985210 A ZA 985210A ZA 985210 A ZA985210 A ZA 985210A ZA 985210 B ZA985210 B ZA 985210B
Authority
ZA
South Africa
Prior art keywords
inhibition
compounds
protein transferase
farnesyl protein
farnesyl
Prior art date
Application number
ZA985210A
Other languages
English (en)
Inventor
Ronald J Doll
Joseph M Kelly
Alan K Mallams
F George Njoroge
Stacy W Remiszewski
Arthur G Taveras
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA985210B publication Critical patent/ZA985210B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA985210A 1997-06-17 1998-06-15 Compounds for the inhibition of farnesyl protein transferase ZA985210B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
ZA985210B true ZA985210B (en) 1999-01-07

Family

ID=25369159

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA985210A ZA985210B (en) 1997-06-17 1998-06-15 Compounds for the inhibition of farnesyl protein transferase

Country Status (30)

Country Link
EP (2) EP0988300B1 (de)
JP (1) JP2002504148A (de)
KR (1) KR100588799B1 (de)
CN (1) CN1131228C (de)
AR (1) AR016074A1 (de)
AT (1) ATE222905T1 (de)
AU (1) AU753863B2 (de)
BR (1) BR9811470A (de)
CA (1) CA2294347C (de)
CO (1) CO4940455A1 (de)
CZ (1) CZ297450B6 (de)
DE (1) DE69807477T2 (de)
DK (1) DK0988300T3 (de)
ES (1) ES2178224T3 (de)
HK (1) HK1022908A1 (de)
HU (1) HUP0003046A3 (de)
ID (1) ID30349A (de)
IL (2) IL133449A0 (de)
MY (1) MY117925A (de)
NO (1) NO318938B1 (de)
NZ (1) NZ501618A (de)
PE (1) PE83799A1 (de)
PL (1) PL191866B1 (de)
PT (1) PT988300E (de)
RU (1) RU2220139C2 (de)
SK (1) SK283820B6 (de)
TR (2) TR200003580T2 (de)
TW (1) TW544451B (de)
WO (1) WO1998057959A1 (de)
ZA (1) ZA985210B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
PE20020635A1 (es) * 2000-11-29 2002-07-11 Schering Corp Compuestos triciclicos como inhibidores de la farnesil transferasa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
RU2220139C2 (ru) 2003-12-27
DK0988300T3 (da) 2002-11-25
IL133449A (en) 2006-12-10
SK283820B6 (sk) 2004-02-03
NO318938B1 (no) 2005-05-30
PT988300E (pt) 2002-12-31
NO996236L (no) 2000-02-01
HUP0003046A2 (hu) 2001-06-28
TR200003580T2 (tr) 2002-10-21
AR016074A1 (es) 2001-06-20
CO4940455A1 (es) 2000-07-24
ES2178224T3 (es) 2002-12-16
ATE222905T1 (de) 2002-09-15
HK1022908A1 (en) 2000-08-25
CZ447199A3 (cs) 2000-06-14
DE69807477T2 (de) 2003-02-27
PL191866B1 (pl) 2006-07-31
CN1131228C (zh) 2003-12-17
WO1998057959A1 (en) 1998-12-23
JP2002504148A (ja) 2002-02-05
EP1156046A1 (de) 2001-11-21
KR20010013948A (ko) 2001-02-26
NZ501618A (en) 2001-10-26
CA2294347C (en) 2008-01-29
CZ297450B6 (cs) 2006-12-13
TR200000114T2 (tr) 2000-08-21
AU753863B2 (en) 2002-10-31
CA2294347A1 (en) 1998-12-23
TW544451B (en) 2003-08-01
DE69807477D1 (de) 2002-10-02
EP0988300B1 (de) 2002-08-28
HUP0003046A3 (en) 2002-11-28
ID30349A (id) 2001-11-22
NO996236D0 (no) 1999-12-16
EP0988300A1 (de) 2000-03-29
SK182499A3 (en) 2000-09-12
MY117925A (en) 2004-08-30
PE83799A1 (es) 1999-10-23
CN1267294A (zh) 2000-09-20
BR9811470A (pt) 2000-09-19
PL337481A1 (en) 2000-08-28
KR100588799B1 (ko) 2006-06-13
IL133449A0 (en) 2001-04-30
AU8058298A (en) 1999-01-04

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