ZA983383B - Process for the fermentative production of cephalosporin - Google Patents

Process for the fermentative production of cephalosporin

Info

Publication number
ZA983383B
ZA983383B ZA983383A ZA983383A ZA983383B ZA 983383 B ZA983383 B ZA 983383B ZA 983383 A ZA983383 A ZA 983383A ZA 983383 A ZA983383 A ZA 983383A ZA 983383 B ZA983383 B ZA 983383B
Authority
ZA
South Africa
Prior art keywords
cephalosporin
organic solvent
extraction
cephalosporin compound
substituted
Prior art date
Application number
ZA983383A
Other languages
English (en)
Inventor
John Krijgsman
Jan Willem Hubert Smeets
Henriette Elisabeth Anna Braal
Erik De Vroom
Herman Pieter Fasel
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA983383B publication Critical patent/ZA983383B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA983383A 1997-04-22 1998-04-22 Process for the fermentative production of cephalosporin ZA983383B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201201 1997-04-22

Publications (1)

Publication Number Publication Date
ZA983383B true ZA983383B (en) 1998-10-27

Family

ID=8228241

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983383A ZA983383B (en) 1997-04-22 1998-04-22 Process for the fermentative production of cephalosporin

Country Status (16)

Country Link
US (1) US6319684B1 (de)
EP (1) EP0918878B1 (de)
JP (1) JP2000512510A (de)
CN (1) CN1137271C (de)
AT (1) ATE288962T1 (de)
AU (1) AU7759298A (de)
BR (1) BR9804855A (de)
DE (1) DE69828940T2 (de)
ES (1) ES2237840T3 (de)
PL (1) PL330706A1 (de)
PT (1) PT918878E (de)
RO (1) RO120653B1 (de)
RU (1) RU2203323C2 (de)
TW (1) TW565612B (de)
WO (1) WO1998048036A1 (de)
ZA (1) ZA983383B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2186347T3 (es) * 1998-03-27 2003-05-01 Dsm Nv Nuevo procedimiento de produccion por fermentacion de cefalosporina.
CA2408853C (en) * 2000-05-13 2012-01-10 Smithkline Beecham P.L.C. Process
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
EP2681224B1 (de) * 2011-03-03 2016-06-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Abbau von penicillinverbindungen
CN111875621A (zh) * 2020-08-26 2020-11-03 山东鲁抗医药股份有限公司 一种注射用头孢菌素盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1299883A (fr) * 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
GB1473100A (de) * 1973-05-10 1977-05-11
DE3729338A1 (de) * 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
US5318896A (en) 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
DE69434023D1 (de) 1993-07-30 2004-10-28 Dsm Ip Assets Bv Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G

Also Published As

Publication number Publication date
BR9804855A (pt) 1999-08-24
JP2000512510A (ja) 2000-09-26
CN1224470A (zh) 1999-07-28
RO120653B1 (ro) 2006-05-30
RU2203323C2 (ru) 2003-04-27
US6319684B1 (en) 2001-11-20
CN1137271C (zh) 2004-02-04
EP0918878B1 (de) 2005-02-09
EP0918878A1 (de) 1999-06-02
ES2237840T3 (es) 2005-08-01
DE69828940D1 (de) 2005-03-17
ATE288962T1 (de) 2005-02-15
PL330706A1 (en) 1999-05-24
WO1998048036A1 (en) 1998-10-29
AU7759298A (en) 1998-11-13
PT918878E (pt) 2005-05-31
TW565612B (en) 2003-12-11
DE69828940T2 (de) 2005-12-29

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