ZA982136B - Novel carboxylic acid derivatives, their preparation and use in treating cancer. - Google Patents

Novel carboxylic acid derivatives, their preparation and use in treating cancer.

Info

Publication number
ZA982136B
ZA982136B ZA9802136A ZA982136A ZA982136B ZA 982136 B ZA982136 B ZA 982136B ZA 9802136 A ZA9802136 A ZA 9802136A ZA 982136 A ZA982136 A ZA 982136A ZA 982136 B ZA982136 B ZA 982136B
Authority
ZA
South Africa
Prior art keywords
preparation
carboxylic acid
acid derivatives
treating cancer
novel carboxylic
Prior art date
Application number
ZA9802136A
Other languages
English (en)
Inventor
Cynthia A Romerdahl
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA982136B publication Critical patent/ZA982136B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9802136A 1997-03-14 1998-03-13 Novel carboxylic acid derivatives, their preparation and use in treating cancer. ZA982136B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/818,622 US6030975A (en) 1997-03-14 1997-03-14 Carboxylic acid derivatives, their preparation and use in treating cancer

Publications (1)

Publication Number Publication Date
ZA982136B true ZA982136B (en) 1999-09-13

Family

ID=25225984

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9802136A ZA982136B (en) 1997-03-14 1998-03-13 Novel carboxylic acid derivatives, their preparation and use in treating cancer.

Country Status (19)

Country Link
US (1) US6030975A (hu)
EP (1) EP0969841A1 (hu)
JP (1) JP2001517220A (hu)
KR (1) KR20000076252A (hu)
CN (1) CN1251991A (hu)
AU (2) AU734696B2 (hu)
BG (1) BG103729A (hu)
BR (1) BR9808263A (hu)
CA (1) CA2283732A1 (hu)
HR (1) HRP980126A2 (hu)
HU (1) HUP0002249A3 (hu)
ID (1) ID24283A (hu)
IL (1) IL131666A0 (hu)
NO (1) NO994426L (hu)
NZ (1) NZ337557A (hu)
PL (1) PL335688A1 (hu)
SK (1) SK125299A3 (hu)
WO (1) WO1998041206A1 (hu)
ZA (1) ZA982136B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533023B4 (de) 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19850301A1 (de) * 1998-10-30 2000-05-04 Basf Ag Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
US6545048B1 (en) * 1999-06-29 2003-04-08 California Institute Of Technology Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity
CA2395711A1 (en) * 2000-02-16 2002-07-18 Yamanouchi Pharmaceutical Co., Ltd. Pharmaceutical compositions
WO2002064573A1 (de) * 2001-02-14 2002-08-22 Abbott Gmbh & Co. Kg Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
CN1568999A (zh) * 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
WO2008097468A2 (en) 2007-02-02 2008-08-14 Concert Pharmaceuticals, Inc. Selective endothelin type-a antagonists
MX356796B (es) 2009-12-07 2018-06-14 Cardioxyl Pharmaceuticals Inc Derivados de hidroxilamina bis-acilados.
CN102276536B (zh) * 2011-06-10 2015-04-29 中国科学院化学研究所 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法
CN103709106A (zh) * 2013-12-06 2014-04-09 石家庄博策生物科技有限公司 一种立体选择性制备安立生坦的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382569A (en) * 1991-05-16 1995-01-17 Warner-Lambert Company Endotherlin antagonists
CA2072395A1 (en) * 1991-07-01 1993-01-02 John T. Hunt Bicyclic endothelin analogues
CA2072390A1 (en) * 1991-07-01 1993-01-02 Philip D. Stein Endothelin analogues with alpha-amine substitution at residue 20
AU3968193A (en) * 1992-03-26 1993-10-21 Gensia, Inc. In vivo peptide therapy
SK128794A3 (en) * 1992-04-22 1995-03-08 Warner Lambert Co Peptides, method of their production and pharmaceutical agents on their base
US5550110A (en) * 1992-04-22 1996-08-27 Warner-Lambert Company Endothelin Antagonists II
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CN1049219C (zh) * 1993-08-18 2000-02-09 万有制药株式会社 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物
SK20396A3 (en) * 1993-08-19 1997-03-05 Warner Lambert Co Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
JP3741441B2 (ja) * 1994-08-19 2006-02-01 アボツト・ラボラトリーズ エンドセリン・アンタゴニスト
WO1996011927A1 (en) * 1994-10-12 1996-04-25 Abbott Laboratories Endothelin antagonists
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
CA2211646C (en) * 1995-01-27 2008-09-09 Rhone Poulenc Rorer Limited Substituted phenyl compounds as endothelin antagonists
CA2168154A1 (en) * 1995-02-06 1996-08-07 Natesan Murugesan Substituted biphenyl sulfonamide endothelin antagonists
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
DE19614542A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

Also Published As

Publication number Publication date
ID24283A (id) 2000-07-13
CA2283732A1 (en) 1998-09-24
IL131666A0 (en) 2001-01-28
BR9808263A (pt) 2000-05-16
AU734696B2 (en) 2001-06-21
EP0969841A1 (en) 2000-01-12
NO994426L (no) 1999-11-12
NZ337557A (en) 2001-08-31
WO1998041206A1 (en) 1998-09-24
HUP0002249A3 (en) 2001-11-28
PL335688A1 (en) 2000-05-08
CN1251991A (zh) 2000-05-03
NO994426D0 (no) 1999-09-13
AU744019B2 (en) 2002-02-14
BG103729A (en) 2000-04-28
JP2001517220A (ja) 2001-10-02
HRP980126A2 (en) 1998-12-31
KR20000076252A (ko) 2000-12-26
SK125299A3 (en) 2001-12-03
US6030975A (en) 2000-02-29
HUP0002249A2 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
EP0710667B8 (de) Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
ZA9610784B (en) Quinoline and quinazoline compounds useful in therapy.
HUP9904104A3 (en) Derivates from piperidine-keto acid,their preparation and use
AU3480297A (en) Modified mcm-56, its preparation and use
HUP9901312A3 (en) Novel alfa-hydroxylic acid derivatives, their production and use
ZA200001746B (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use.
HK1040980A1 (zh) 聯苯磺酰基氨基氰、其製備方法及其作為藥物的用途
AU3301700A (en) (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy
ZA982136B (en) Novel carboxylic acid derivatives, their preparation and use in treating cancer.
HUP9901315A3 (en) New carboxzlic acid derivatives, their production and use
IL129927A0 (en) 1,4-Diazabicyclo (2.2.2) oct-2-ylmethyl derivatives their preparation and therapeutic application
SI1000063T1 (en) 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO(4,5-b)INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
ZA989664B (en) 3-substituted tetrahydropyrimidinone derivatives, their preparation and use.
HRP970200A2 (en) Novel carboxylic acid derivatives, their production and use
PL347633A1 (en) Certain substituted caprolactams, pharmaceutical compositions containing them and their use in treating tumors
ZA976479B (en) Alfa-amino acids amides, preparation thereof and the therapeutical use thereof.
ZA9810625B (en) Benzylidenepyrazolones, their preparation and use.
ZA972894B (en) Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics.
ZA976619B (en) Benzimidazole derivatives, their preparation and their therapeutic applications.
GR3035834T3 (en) Benzoxazindione derivatives, process for their preparation and their use
ZA967537B (en) Novel carboxylic acid derivatives, their preparation and use.
IL133536A0 (en) 6-pyrrolidin-2-ylpyridine derivatives, their preparation and application in therapy
ZA987660B (en) Novel tissue-specific calpains, their preparation and use.
ZA977767B (en) Benzylamine derivatives, their preparation and their application in therapeutics.
ZA9810403B (en) New epothilon derivatives, process for their preparation and their pharmaceutical use.