BR9808263A - Processos para tratar câncer em um humano em necessidade de tratamento e para manufaturar um medicamento para inibir o crescimento em um humano de um tumor sólido, e, uso de um composto. - Google Patents
Processos para tratar câncer em um humano em necessidade de tratamento e para manufaturar um medicamento para inibir o crescimento em um humano de um tumor sólido, e, uso de um composto.Info
- Publication number
- BR9808263A BR9808263A BR9808263-9A BR9808263A BR9808263A BR 9808263 A BR9808263 A BR 9808263A BR 9808263 A BR9808263 A BR 9808263A BR 9808263 A BR9808263 A BR 9808263A
- Authority
- BR
- Brazil
- Prior art keywords
- human
- compound
- processes
- treatment
- need
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSOS PARA TRATAR CâNCER EM UM HUMANO EM NECESSIDADE DE TRATAMENTO, E, USO DE UM COMPOSTO". Esta invenção fornece um processo para tratar câncer em um indivíduo, em que o câncer é um tumor em que o endotélio é supra-regulado (p.ex., tumores, pulmão, fígado, mama, cérebro, estómago, colon, endométrio, testículos, tiróide, pituitária, bexiga, rins, pâncreas e meninges) pela administração ao indivíduo de uma quantidade eficaz de um composto de fórmula (I) ou fórmula (Ia), como aqui descrito.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/818,622 US6030975A (en) | 1997-03-14 | 1997-03-14 | Carboxylic acid derivatives, their preparation and use in treating cancer |
PCT/US1998/004596 WO1998041206A1 (en) | 1997-03-14 | 1998-03-09 | Novel carboxylic acid derivatives, their preparation and use in treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808263A true BR9808263A (pt) | 2000-05-16 |
Family
ID=25225984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808263-9A BR9808263A (pt) | 1997-03-14 | 1998-03-09 | Processos para tratar câncer em um humano em necessidade de tratamento e para manufaturar um medicamento para inibir o crescimento em um humano de um tumor sólido, e, uso de um composto. |
Country Status (19)
Country | Link |
---|---|
US (1) | US6030975A (pt) |
EP (1) | EP0969841A1 (pt) |
JP (1) | JP2001517220A (pt) |
KR (1) | KR20000076252A (pt) |
CN (1) | CN1251991A (pt) |
AU (2) | AU744019B2 (pt) |
BG (1) | BG103729A (pt) |
BR (1) | BR9808263A (pt) |
CA (1) | CA2283732A1 (pt) |
HR (1) | HRP980126A2 (pt) |
HU (1) | HUP0002249A3 (pt) |
ID (1) | ID24283A (pt) |
IL (1) | IL131666A0 (pt) |
NO (1) | NO994426L (pt) |
NZ (1) | NZ337557A (pt) |
PL (1) | PL335688A1 (pt) |
SK (1) | SK125299A3 (pt) |
WO (1) | WO1998041206A1 (pt) |
ZA (1) | ZA982136B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
DE19850301A1 (de) * | 1998-10-30 | 2000-05-04 | Basf Ag | Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren |
US7566452B1 (en) * | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
US6545048B1 (en) * | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
AR031679A1 (es) * | 2000-02-16 | 2003-10-01 | Astellas Pharma Inc | Una composicion farmaceutica |
WO2002064573A1 (de) * | 2001-02-14 | 2002-08-22 | Abbott Gmbh & Co. Kg | Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten |
CN1568999A (zh) * | 2003-07-14 | 2005-01-26 | 南宁枫叶药业有限公司 | 稳定的医药用河豚毒素冷冻干燥制剂 |
EP2118073A2 (en) | 2007-02-02 | 2009-11-18 | Concert Pharmaceuticals Inc. | Selective endothelin type-a antagonists |
CA2782248A1 (en) | 2009-12-07 | 2011-06-16 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
CN102276536B (zh) * | 2011-06-10 | 2015-04-29 | 中国科学院化学研究所 | 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法 |
CN103709106A (zh) * | 2013-12-06 | 2014-04-09 | 石家庄博策生物科技有限公司 | 一种立体选择性制备安立生坦的方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5382569A (en) * | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
CA2072395A1 (en) * | 1991-07-01 | 1993-01-02 | John T. Hunt | Bicyclic endothelin analogues |
CA2072390A1 (en) * | 1991-07-01 | 1993-01-02 | Philip D. Stein | Endothelin analogues with alpha-amine substitution at residue 20 |
WO1993018794A1 (en) * | 1992-03-26 | 1993-09-30 | Gensia, Inc. | In vivo peptide therapy |
CZ256994A3 (en) * | 1992-04-22 | 1995-02-15 | Warner Lambert Co | Peptides, process of their preparation and pharmaceutical compositions based thereof |
US5550110A (en) * | 1992-04-22 | 1996-08-27 | Warner-Lambert Company | Endothelin Antagonists II |
WO1994003483A1 (en) * | 1992-07-30 | 1994-02-17 | Chiron Corporation | Endothelin receptor-binding compounds |
TW333456B (en) * | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
EP0714897B1 (en) * | 1993-08-18 | 2001-02-14 | Banyu Pharmaceutical Co., Ltd. | Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity |
CA2165567A1 (en) * | 1993-08-19 | 1995-02-23 | Kent Alan Berryman | Substituted 2(5h)furanone, 2(5h)thiophenone and 2(5h)pyrrolone derivatives, their preparation and their use as endothelien antagonists |
DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
EP1186603A3 (en) * | 1994-08-19 | 2003-07-09 | Abbott Laboratories | Processes for preparing endothelin antagonists |
WO1996011927A1 (en) * | 1994-10-12 | 1996-04-25 | Abbott Laboratories | Endothelin antagonists |
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
CZ223697A3 (en) * | 1995-01-27 | 1997-12-17 | Rhone Poulenc Rorer Ltd | Substituted phenyl derivatives as endothelin antagonists |
IL116916A (en) * | 1995-02-06 | 2000-09-28 | Bristol Myers Squibb Co | Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same |
DE19614542A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
DE19614533A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung |
DE19614534A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
-
1997
- 1997-03-14 US US08/818,622 patent/US6030975A/en not_active Expired - Lifetime
-
1998
- 1998-03-09 AU AU66946/98D patent/AU744019B2/en not_active Ceased
- 1998-03-09 ID IDW991021A patent/ID24283A/id unknown
- 1998-03-09 PL PL98335688A patent/PL335688A1/xx unknown
- 1998-03-09 EP EP98909067A patent/EP0969841A1/en not_active Withdrawn
- 1998-03-09 HU HU0002249A patent/HUP0002249A3/hu unknown
- 1998-03-09 NZ NZ337557A patent/NZ337557A/en unknown
- 1998-03-09 BR BR9808263-9A patent/BR9808263A/pt not_active IP Right Cessation
- 1998-03-09 CA CA002283732A patent/CA2283732A1/en not_active Abandoned
- 1998-03-09 WO PCT/US1998/004596 patent/WO1998041206A1/en not_active Application Discontinuation
- 1998-03-09 SK SK1252-99A patent/SK125299A3/sk unknown
- 1998-03-09 KR KR1019997008347A patent/KR20000076252A/ko not_active Application Discontinuation
- 1998-03-09 CN CN98803904A patent/CN1251991A/zh active Pending
- 1998-03-09 AU AU6694698A patent/AU734696B2/xx not_active Expired - Lifetime
- 1998-03-09 IL IL13166698A patent/IL131666A0/xx unknown
- 1998-03-09 JP JP54057398A patent/JP2001517220A/ja active Pending
- 1998-03-10 HR HR08/818,622A patent/HRP980126A2/hr not_active Application Discontinuation
- 1998-03-13 ZA ZA9802136A patent/ZA982136B/xx unknown
-
1999
- 1999-09-13 BG BG103729A patent/BG103729A/xx unknown
- 1999-09-13 NO NO994426A patent/NO994426L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JP2001517220A (ja) | 2001-10-02 |
NZ337557A (en) | 2001-08-31 |
ZA982136B (en) | 1999-09-13 |
EP0969841A1 (en) | 2000-01-12 |
HRP980126A2 (en) | 1998-12-31 |
KR20000076252A (ko) | 2000-12-26 |
CN1251991A (zh) | 2000-05-03 |
AU734696B2 (en) | 2001-06-21 |
US6030975A (en) | 2000-02-29 |
HUP0002249A2 (hu) | 2001-05-28 |
WO1998041206A1 (en) | 1998-09-24 |
ID24283A (id) | 2000-07-13 |
AU744019B2 (en) | 2002-02-14 |
NO994426L (no) | 1999-11-12 |
PL335688A1 (en) | 2000-05-08 |
IL131666A0 (en) | 2001-01-28 |
NO994426D0 (no) | 1999-09-13 |
SK125299A3 (en) | 2001-12-03 |
CA2283732A1 (en) | 1998-09-24 |
BG103729A (en) | 2000-04-28 |
HUP0002249A3 (en) | 2001-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A, 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007. |