PT954299E - Analogos de tiroxina sem actividade hormonal significativa, para o tratamento de tumores malignos - Google Patents
Analogos de tiroxina sem actividade hormonal significativa, para o tratamento de tumores malignosInfo
- Publication number
- PT954299E PT954299E PT97927813T PT97927813T PT954299E PT 954299 E PT954299 E PT 954299E PT 97927813 T PT97927813 T PT 97927813T PT 97927813 T PT97927813 T PT 97927813T PT 954299 E PT954299 E PT 954299E
- Authority
- PT
- Portugal
- Prior art keywords
- malignant tumors
- treatment
- thyroxine
- significant hormonal
- analogues
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/655,267 US5736576A (en) | 1996-06-04 | 1996-06-04 | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
US08/833,272 US6017958A (en) | 1996-06-04 | 1997-04-03 | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
Publications (1)
Publication Number | Publication Date |
---|---|
PT954299E true PT954299E (pt) | 2005-11-30 |
Family
ID=27096941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97927813T PT954299E (pt) | 1996-06-04 | 1997-05-30 | Analogos de tiroxina sem actividade hormonal significativa, para o tratamento de tumores malignos |
Country Status (15)
Country | Link |
---|---|
US (1) | US6017958A (pt) |
EP (1) | EP0954299B1 (pt) |
JP (1) | JP4188416B2 (pt) |
CN (1) | CN1154486C (pt) |
AT (1) | ATE300292T1 (pt) |
AU (1) | AU730261B2 (pt) |
BR (1) | BR9710686A (pt) |
CA (1) | CA2257235C (pt) |
DE (1) | DE69733834T2 (pt) |
DK (1) | DK0954299T3 (pt) |
ES (1) | ES2246514T3 (pt) |
IL (1) | IL127384A0 (pt) |
NZ (1) | NZ333356A (pt) |
PT (1) | PT954299E (pt) |
WO (1) | WO1997046228A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922775A (en) * | 1997-10-23 | 1999-07-13 | Octamer, Inc. | Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity |
JP2002507567A (ja) * | 1998-03-25 | 2002-03-12 | ラージ スケール バイオロジー コーポレイション | 血管形成を阻害するための安息香酸誘導体 |
US6433012B1 (en) * | 1998-03-25 | 2002-08-13 | Large Scale Biology Corp. | Method for inhibiting inflammatory disease |
US6740680B1 (en) * | 1999-04-26 | 2004-05-25 | Becton Pharma, Inc. | Pharmaceutical compositions to tetrac and methods of use thereof |
US6638977B1 (en) | 1999-11-19 | 2003-10-28 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists |
US6677473B1 (en) | 1999-11-19 | 2004-01-13 | Corvas International Inc | Plasminogen activator inhibitor antagonists |
US7504435B2 (en) | 2001-01-31 | 2009-03-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method for stimulating weight loss and/or for lowering triglycerides in patients |
US20050159490A1 (en) * | 2001-01-31 | 2005-07-21 | Eugene Morkin | Method to treat chronic heart failure and/or elevated cholesterol levels |
AUPR500201A0 (en) | 2001-05-14 | 2001-06-07 | Commonwealth Scientific And Industrial Research Organisation | Recovery of minerals by flotation |
IL165323A0 (en) | 2002-06-06 | 2006-01-15 | Canbas Co Ltd | Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
US7358046B2 (en) * | 2003-08-08 | 2008-04-15 | Canbas Co., Ltd. | Sensitivity test to predict efficacy of anti-cancer therapies |
US20050249667A1 (en) * | 2004-03-24 | 2005-11-10 | Tuszynski Jack A | Process for treating a biological organism |
JP5177429B2 (ja) * | 2005-07-18 | 2013-04-03 | バイパー サイエンシズ,インコーポレイティド | 癌の治療 |
EP1953148B1 (en) | 2005-10-28 | 2012-02-29 | Takeda Pharmaceutical Company Limited | Heterocyclic amide compound and use thereof |
US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
US20080262062A1 (en) * | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
US20070292883A1 (en) * | 2006-06-12 | 2007-12-20 | Ossovskaya Valeria S | Method of treating diseases with PARP inhibitors |
AU2007292387A1 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
CA2662335A1 (en) * | 2006-09-05 | 2008-03-13 | Valeria Ossovskaya | Methods for designing parp inhibitors and uses thereof |
US7538252B2 (en) * | 2006-09-05 | 2009-05-26 | Bipar Sciences, Inc. | Drug design for tubulin inhibitors, compositions, and methods of treatment thereof |
EP2061479A4 (en) * | 2006-09-05 | 2010-08-04 | Bipar Sciences Inc | FETTIC ACID SYNTHESIS INHIBITED BY PARP HEMMER AND TREATMENT PROCEDURES THEREWITH |
US8133859B2 (en) | 2006-09-27 | 2012-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | SCGB3A2 as a growth factor and anti-apoptotic agent |
CN101903025A (zh) * | 2007-10-19 | 2010-12-01 | 彼帕科学公司 | 利用苯并吡喃酮-型parp抑制剂治疗癌症的方法和组合物 |
MX2010005221A (es) * | 2007-11-12 | 2010-09-28 | Bipar Sciences Inc | Tratamiento de cancer de utero y cancer de ovario con un inhibidor de parp solo o en combinacion con agentes antitumorales. |
CA2705537A1 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents |
WO2009073869A1 (en) * | 2007-12-07 | 2009-06-11 | Bipar Sciences, Inc. | Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors |
CN101999002A (zh) * | 2008-02-04 | 2011-03-30 | 彼帕科学公司 | 诊断和治疗parp-介导的疾病的方法 |
CN102858156B (zh) | 2010-04-28 | 2015-09-23 | 奥斯娜特·阿舒尔-费边 | 用于提供治疗的方法、组合物和试剂盒 |
HUE035222T2 (hu) * | 2012-08-20 | 2018-05-02 | Merck Patent Gmbh | Levotiroxint tartalmazó szilárd gyógyszerészeti készítmények |
US10874641B2 (en) | 2016-07-28 | 2020-12-29 | Mitobridge, Inc. | Methods of treating acute kidney injury |
JP2020500214A (ja) | 2016-11-02 | 2020-01-09 | イミュノジェン・インコーポレーテッド | 抗体薬物複合体とparp阻害剤との併用治療 |
EP3655418A4 (en) | 2017-06-22 | 2021-05-19 | Triact Therapeutics, Inc. | METHOD OF TREATMENT OF GLIOBLASTOMA |
EP3687501A4 (en) | 2017-09-29 | 2021-06-23 | Triact Therapeutics, Inc. | INIPARIB FORMS AND USES THEREOF |
US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB642159A (en) * | 1947-10-23 | 1950-08-30 | Glaxo Lab Ltd | Improvements in or relating to the preparation of diphenyl ethers |
GB643089A (en) * | 1947-10-23 | 1950-09-15 | Glaxo Lab Ltd | Improvements in or relating to the preparation of 2:6-dihalogeno diphenyl ethers |
US4724234A (en) * | 1982-09-17 | 1988-02-09 | Therapeutical Systems Corp. | Method for producing oncolysis |
US4816255A (en) * | 1985-07-31 | 1989-03-28 | Ghent William R | Treatment of iodine deficiency breast syndrome |
WO1993002444A1 (en) * | 1991-07-24 | 1993-02-04 | Vladislav Vladimirovich Volkov | Tensioning device for keyboard stringed musical instrument |
AU4090093A (en) * | 1992-05-29 | 1993-12-30 | Yamanouchi Pharmaceutical Co., Ltd. | Medicine containing benzoic acid derivative and novel benzoic acid derivative |
US5736576A (en) * | 1996-06-04 | 1998-04-07 | Octamer, Inc. | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
US5922775A (en) * | 1997-10-23 | 1999-07-13 | Octamer, Inc. | Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity |
-
1997
- 1997-04-03 US US08/833,272 patent/US6017958A/en not_active Expired - Lifetime
- 1997-05-30 ES ES97927813T patent/ES2246514T3/es not_active Expired - Lifetime
- 1997-05-30 DK DK97927813T patent/DK0954299T3/da active
- 1997-05-30 CA CA002257235A patent/CA2257235C/en not_active Expired - Fee Related
- 1997-05-30 IL IL12738497A patent/IL127384A0/xx unknown
- 1997-05-30 AU AU32182/97A patent/AU730261B2/en not_active Ceased
- 1997-05-30 NZ NZ333356A patent/NZ333356A/en not_active IP Right Cessation
- 1997-05-30 BR BR9710686-0A patent/BR9710686A/pt not_active Application Discontinuation
- 1997-05-30 EP EP97927813A patent/EP0954299B1/en not_active Expired - Lifetime
- 1997-05-30 WO PCT/US1997/009086 patent/WO1997046228A1/en active IP Right Grant
- 1997-05-30 AT AT97927813T patent/ATE300292T1/de active
- 1997-05-30 PT PT97927813T patent/PT954299E/pt unknown
- 1997-05-30 CN CNB971969795A patent/CN1154486C/zh not_active Expired - Fee Related
- 1997-05-30 JP JP50067098A patent/JP4188416B2/ja not_active Expired - Lifetime
- 1997-05-30 DE DE69733834T patent/DE69733834T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1997046228A1 (en) | 1997-12-11 |
ES2246514T3 (es) | 2006-02-16 |
US6017958A (en) | 2000-01-25 |
EP0954299B1 (en) | 2005-07-27 |
ATE300292T1 (de) | 2005-08-15 |
DE69733834D1 (de) | 2005-09-01 |
DK0954299T3 (da) | 2005-10-31 |
BR9710686A (pt) | 2000-01-11 |
AU3218297A (en) | 1998-01-05 |
CA2257235C (en) | 2007-01-30 |
DE69733834T2 (de) | 2006-06-01 |
EP0954299A4 (en) | 2000-09-06 |
JP2001501590A (ja) | 2001-02-06 |
AU730261B2 (en) | 2001-03-01 |
IL127384A0 (en) | 1999-10-28 |
CN1154486C (zh) | 2004-06-23 |
CA2257235A1 (en) | 1997-12-11 |
JP4188416B2 (ja) | 2008-11-26 |
NZ333356A (en) | 2000-06-23 |
CN1226826A (zh) | 1999-08-25 |
EP0954299A1 (en) | 1999-11-10 |
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