BR9710686A - Método de tratamento de tumores malignos com tiroxinas análogas não possuindo atividade hormonal siginificativa. - Google Patents

Método de tratamento de tumores malignos com tiroxinas análogas não possuindo atividade hormonal siginificativa.

Info

Publication number
BR9710686A
BR9710686A BR9710686-0A BR9710686A BR9710686A BR 9710686 A BR9710686 A BR 9710686A BR 9710686 A BR9710686 A BR 9710686A BR 9710686 A BR9710686 A BR 9710686A
Authority
BR
Brazil
Prior art keywords
malignant tumors
hormonal activity
thyroxines
analogous
treatment
Prior art date
Application number
BR9710686-0A
Other languages
English (en)
Inventor
Ernest Kun
Jerome Mendeleyev
Original Assignee
Octamer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/655,267 external-priority patent/US5736576A/en
Application filed by Octamer Inc filed Critical Octamer Inc
Publication of BR9710686A publication Critical patent/BR9710686A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

''MéTODO DE TRATAMENTO DE TUMORES MALIGNOS COM TIROXIMAS ANáLOGOS NãO POSSUINDO ATIVIDADE HORMONAL SIGNIFICATIVA''. A presente invenção fornece métodos para tratar câncer, particularmente tumores malignos com tiroxina análogas não possuindo atividade hormonal significativa. A tiroxina análoga é administrada em um mamífero doente em uma quantidade eficaz de maneira a causar depressão ou regressão do crescimento do tumor maligno ou para tratar o câncer. As tiroxinas anólogas particularmente preferidas são aquelas capazes de proprocionar cerca de 35% ou mais de inibição da velocidade inicial do conjunto de proteína em microtubulo in vitro.
BR9710686-0A 1996-06-04 1997-05-30 Método de tratamento de tumores malignos com tiroxinas análogas não possuindo atividade hormonal siginificativa. BR9710686A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/655,267 US5736576A (en) 1996-06-04 1996-06-04 Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US08/833,272 US6017958A (en) 1996-06-04 1997-04-03 Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
PCT/US1997/009086 WO1997046228A1 (en) 1996-06-04 1997-05-30 Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity

Publications (1)

Publication Number Publication Date
BR9710686A true BR9710686A (pt) 2000-01-11

Family

ID=27096941

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710686-0A BR9710686A (pt) 1996-06-04 1997-05-30 Método de tratamento de tumores malignos com tiroxinas análogas não possuindo atividade hormonal siginificativa.

Country Status (15)

Country Link
US (1) US6017958A (pt)
EP (1) EP0954299B1 (pt)
JP (1) JP4188416B2 (pt)
CN (1) CN1154486C (pt)
AT (1) ATE300292T1 (pt)
AU (1) AU730261B2 (pt)
BR (1) BR9710686A (pt)
CA (1) CA2257235C (pt)
DE (1) DE69733834T2 (pt)
DK (1) DK0954299T3 (pt)
ES (1) ES2246514T3 (pt)
IL (1) IL127384A0 (pt)
NZ (1) NZ333356A (pt)
PT (1) PT954299E (pt)
WO (1) WO1997046228A1 (pt)

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US5922775A (en) * 1997-10-23 1999-07-13 Octamer, Inc. Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity
JP2002507567A (ja) * 1998-03-25 2002-03-12 ラージ スケール バイオロジー コーポレイション 血管形成を阻害するための安息香酸誘導体
US6433012B1 (en) * 1998-03-25 2002-08-13 Large Scale Biology Corp. Method for inhibiting inflammatory disease
US6740680B1 (en) * 1999-04-26 2004-05-25 Becton Pharma, Inc. Pharmaceutical compositions to tetrac and methods of use thereof
WO2001036351A2 (en) 1999-11-19 2001-05-25 Corvas International, Inc. Plasminogen activator inhibitor antagonists related applications
US6638977B1 (en) 1999-11-19 2003-10-28 Corvas International, Inc. Plasminogen activator inhibitor antagonists
US20050159490A1 (en) * 2001-01-31 2005-07-21 Eugene Morkin Method to treat chronic heart failure and/or elevated cholesterol levels
US7504435B2 (en) * 2001-01-31 2009-03-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for stimulating weight loss and/or for lowering triglycerides in patients
AUPR500201A0 (en) 2001-05-14 2001-06-07 Commonwealth Scientific And Industrial Research Organisation Recovery of minerals by flotation
CN100577631C (zh) 2002-06-06 2010-01-06 坎巴斯有限公司 消除dna损伤导致的细胞周期g2关卡和/或增强dna损伤性治疗抗癌活性的化合物
US7358046B2 (en) * 2003-08-08 2008-04-15 Canbas Co., Ltd. Sensitivity test to predict efficacy of anti-cancer therapies
US20050249667A1 (en) * 2004-03-24 2005-11-10 Tuszynski Jack A Process for treating a biological organism
KR20080035630A (ko) * 2005-07-18 2008-04-23 바이파 사이언스 인코포레이티드 암의 치료
US7915267B2 (en) 2005-10-28 2011-03-29 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
CA2655257A1 (en) * 2006-06-12 2008-12-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080262062A1 (en) * 2006-11-20 2008-10-23 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
WO2008030892A2 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
EP2061479A4 (en) * 2006-09-05 2010-08-04 Bipar Sciences Inc FETTIC ACID SYNTHESIS INHIBITED BY PARP HEMMER AND TREATMENT PROCEDURES THEREWITH
US8143447B2 (en) * 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
AU2007292302A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing PARP inhibitors and uses thereof
US8133859B2 (en) * 2006-09-27 2012-03-13 The United States Of America As Represented By The Department Of Health And Human Services SCGB3A2 as a growth factor and anti-apoptotic agent
EP2211854A4 (en) * 2007-10-19 2011-01-12 Bipar Sciences Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS
KR20100102609A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법
JP2011503071A (ja) * 2007-11-12 2011-01-27 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる子宮がん及び卵巣がんの治療
WO2009073869A1 (en) * 2007-12-07 2009-06-11 Bipar Sciences, Inc. Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors
AU2009212401A1 (en) * 2008-02-04 2009-08-13 Bipar Sciences, Inc. Methods of diagnosing and treating PARP-mediated diseases
BR112012027463A2 (pt) 2010-04-28 2015-09-29 Aleck Hercbergs método terapêutico, composição farmacêutica, uso de tri-iodotironina (t3) ou de análogo bioquímico da mesma, tri-iodotironina (t3) ou um análogo bioquímico da mesma, e, kit
EP2885005B1 (en) * 2012-08-20 2017-09-27 Merck Patent GmbH Solid pharmaceutical preparation containing levothyroxine
US10874641B2 (en) 2016-07-28 2020-12-29 Mitobridge, Inc. Methods of treating acute kidney injury
RU2019114863A (ru) 2016-11-02 2020-12-03 Иммуноджен, Инк. Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp
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WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling

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US5736576A (en) * 1996-06-04 1998-04-07 Octamer, Inc. Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US5883294A (en) * 1997-06-18 1999-03-16 The Regeants Of The University Of California Selective thyroid hormone analogs
US5922775A (en) * 1997-10-23 1999-07-13 Octamer, Inc. Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity

Also Published As

Publication number Publication date
CA2257235C (en) 2007-01-30
JP4188416B2 (ja) 2008-11-26
AU730261B2 (en) 2001-03-01
PT954299E (pt) 2005-11-30
ES2246514T3 (es) 2006-02-16
US6017958A (en) 2000-01-25
DK0954299T3 (da) 2005-10-31
EP0954299A1 (en) 1999-11-10
CN1226826A (zh) 1999-08-25
EP0954299B1 (en) 2005-07-27
CN1154486C (zh) 2004-06-23
JP2001501590A (ja) 2001-02-06
IL127384A0 (en) 1999-10-28
DE69733834D1 (de) 2005-09-01
DE69733834T2 (de) 2006-06-01
WO1997046228A1 (en) 1997-12-11
ATE300292T1 (de) 2005-08-15
CA2257235A1 (en) 1997-12-11
NZ333356A (en) 2000-06-23
AU3218297A (en) 1998-01-05
EP0954299A4 (en) 2000-09-06

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
HJEG Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO DISPOSTO NOS ARTIGOS 8O, 10, 13, 24, 25, E 32 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08H Application fees: decision cancelled [chapter 8.8 patent gazette]