HUP0002249A2 - Pirimidin- és triazinszármazékok alkalmazása rákellenes gyógyszerkészítmények előállítására - Google Patents

Pirimidin- és triazinszármazékok alkalmazása rákellenes gyógyszerkészítmények előállítására

Info

Publication number
HUP0002249A2
HUP0002249A2 HU0002249A HUP0002249A HUP0002249A2 HU P0002249 A2 HUP0002249 A2 HU P0002249A2 HU 0002249 A HU0002249 A HU 0002249A HU P0002249 A HUP0002249 A HU P0002249A HU P0002249 A2 HUP0002249 A2 HU P0002249A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
atom
pyrimidine
pharmaceutical compositions
Prior art date
Application number
HU0002249A
Other languages
English (en)
Inventor
Cynthia A. Romerdahl
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP0002249A2 publication Critical patent/HUP0002249A2/hu
Publication of HUP0002249A3 publication Critical patent/HUP0002249A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát az (I) általános képletű, új karbonsavszármazékok- ahol különösen előnyösen R formil-, tetrazolil-, ciano- vagykarboxicsoport vagy karboxicsoporttá hidrolizálható csoport; R2 alkil-vagy alkoxicsoport; R3 alkil-, alkoxi- vagy alkil-tio-csoport; vagy R3és R14 összekapcsolódva gyűrűt képez: X nitrogénatom vagy =CR14-általános képletű csoport, amelyben R14 hidrogénatom vagyalkilcsoport; R4 és R5 adott esetben szubsztituált fenilcsoport, R6adott esetben szubsztituált alkil-, aril- vagy heteroaril-csoport; Ykén- vagy oxigénatom vagy vegyértékvonal; Z kénatom, oxigénatom,szulfinil- vagy szulfonilcsoport vagy vegyértékvonal - emberben túlnagy mennyiségű endotelint termelő szolid tumorok, különösenprosztatarák kezelésére szolgáló gyógyszerkészítmények előállításáravaló alkalmazása képezi. Ó
HU0002249A 1997-03-14 1998-03-09 Use of pyrimidine and triazine derivatives for producing pharmaceutical compositions useful for treating cancer HUP0002249A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/818,622 US6030975A (en) 1997-03-14 1997-03-14 Carboxylic acid derivatives, their preparation and use in treating cancer
PCT/US1998/004596 WO1998041206A1 (en) 1997-03-14 1998-03-09 Novel carboxylic acid derivatives, their preparation and use in treating cancer

Publications (2)

Publication Number Publication Date
HUP0002249A2 true HUP0002249A2 (hu) 2001-05-28
HUP0002249A3 HUP0002249A3 (en) 2001-11-28

Family

ID=25225984

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002249A HUP0002249A3 (en) 1997-03-14 1998-03-09 Use of pyrimidine and triazine derivatives for producing pharmaceutical compositions useful for treating cancer

Country Status (19)

Country Link
US (1) US6030975A (hu)
EP (1) EP0969841A1 (hu)
JP (1) JP2001517220A (hu)
KR (1) KR20000076252A (hu)
CN (1) CN1251991A (hu)
AU (2) AU734696B2 (hu)
BG (1) BG103729A (hu)
BR (1) BR9808263A (hu)
CA (1) CA2283732A1 (hu)
HR (1) HRP980126A2 (hu)
HU (1) HUP0002249A3 (hu)
ID (1) ID24283A (hu)
IL (1) IL131666A0 (hu)
NO (1) NO994426L (hu)
NZ (1) NZ337557A (hu)
PL (1) PL335688A1 (hu)
SK (1) SK125299A3 (hu)
WO (1) WO1998041206A1 (hu)
ZA (1) ZA982136B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533023B4 (de) 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19850301A1 (de) * 1998-10-30 2000-05-04 Basf Ag Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
US6545048B1 (en) * 1999-06-29 2003-04-08 California Institute Of Technology Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity
AR031679A1 (es) * 2000-02-16 2003-10-01 Astellas Pharma Inc Una composicion farmaceutica
WO2002064573A1 (de) * 2001-02-14 2002-08-22 Abbott Gmbh & Co. Kg Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
CN1568999A (zh) * 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
EP2118073A2 (en) 2007-02-02 2009-11-18 Concert Pharmaceuticals Inc. Selective endothelin type-a antagonists
AU2010328230B2 (en) 2009-12-07 2016-06-02 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
CN102276536B (zh) * 2011-06-10 2015-04-29 中国科学院化学研究所 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法
CN103709106A (zh) * 2013-12-06 2014-04-09 石家庄博策生物科技有限公司 一种立体选择性制备安立生坦的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382569A (en) * 1991-05-16 1995-01-17 Warner-Lambert Company Endotherlin antagonists
CA2072390A1 (en) * 1991-07-01 1993-01-02 Philip D. Stein Endothelin analogues with alpha-amine substitution at residue 20
CA2072395A1 (en) * 1991-07-01 1993-01-02 John T. Hunt Bicyclic endothelin analogues
WO1993018794A1 (en) * 1992-03-26 1993-09-30 Gensia, Inc. In vivo peptide therapy
US5550110A (en) * 1992-04-22 1996-08-27 Warner-Lambert Company Endothelin Antagonists II
NZ252855A (en) * 1992-04-22 1996-11-26 Warner Lambert Co Polypeptide having terminal substituted by an alpha-substituted acetic acid, the substituent being a xanthene, thioxanthene or dibenzocycloheptene derivative
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
EP0714897B1 (en) * 1993-08-18 2001-02-14 Banyu Pharmaceutical Co., Ltd. Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity
AU693110B2 (en) * 1993-08-19 1998-06-25 Warner-Lambert Company Substituted 2(5H)furanone, 2(5H)thiophenone and 2(5H)pyrrolone derivatives, their preparation and their use as endothelin antagonists
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
ATE219077T1 (de) * 1994-08-19 2002-06-15 Abbott Lab Endothelin antagoniste
WO1996011927A1 (en) * 1994-10-12 1996-04-25 Abbott Laboratories Endothelin antagonists
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
AU706940B2 (en) * 1995-01-27 1999-07-01 Rhone-Poulenc Rorer Limited Substituted phenyl compounds as endothelin antagonists
CA2168154A1 (en) * 1995-02-06 1996-08-07 Natesan Murugesan Substituted biphenyl sulfonamide endothelin antagonists
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614542A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten

Also Published As

Publication number Publication date
AU734696B2 (en) 2001-06-21
EP0969841A1 (en) 2000-01-12
CA2283732A1 (en) 1998-09-24
JP2001517220A (ja) 2001-10-02
NO994426D0 (no) 1999-09-13
AU744019B2 (en) 2002-02-14
WO1998041206A1 (en) 1998-09-24
HRP980126A2 (en) 1998-12-31
KR20000076252A (ko) 2000-12-26
BG103729A (en) 2000-04-28
ID24283A (id) 2000-07-13
US6030975A (en) 2000-02-29
NO994426L (no) 1999-11-12
ZA982136B (en) 1999-09-13
CN1251991A (zh) 2000-05-03
HUP0002249A3 (en) 2001-11-28
BR9808263A (pt) 2000-05-16
NZ337557A (en) 2001-08-31
SK125299A3 (en) 2001-12-03
IL131666A0 (en) 2001-01-28
PL335688A1 (en) 2000-05-08

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