ZA9810444B - Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease - Google Patents

Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease

Info

Publication number
ZA9810444B
ZA9810444B ZA9810444A ZA9810444A ZA9810444B ZA 9810444 B ZA9810444 B ZA 9810444B ZA 9810444 A ZA9810444 A ZA 9810444A ZA 9810444 A ZA9810444 A ZA 9810444A ZA 9810444 B ZA9810444 B ZA 9810444B
Authority
ZA
South Africa
Prior art keywords
interphenylene
trinor
methano
deoxy
oxa
Prior art date
Application number
ZA9810444A
Other languages
English (en)
Inventor
James W Crow
Shelmer D Blackburn Jr
Robert Roscigno
Michael Wade
Gilles Cloutier
Martine Rothblatt
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of ZA9810444B publication Critical patent/ZA9810444B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9810444A 1997-11-14 1998-11-16 Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease ZA9810444B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6604997P 1997-11-14 1997-11-14

Publications (1)

Publication Number Publication Date
ZA9810444B true ZA9810444B (en) 1999-06-24

Family

ID=22066941

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9810444A ZA9810444B (en) 1997-11-14 1998-11-16 Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease

Country Status (12)

Country Link
US (1) US6054486A (xx)
EP (1) EP1045695B1 (xx)
JP (2) JP3701870B2 (xx)
KR (1) KR100638684B1 (xx)
CN (1) CN1142781C (xx)
AT (1) ATE262336T1 (xx)
AU (1) AU1373499A (xx)
CA (1) CA2312729C (xx)
DE (1) DE69822665T2 (xx)
ES (1) ES2214753T3 (xx)
WO (1) WO1999025357A1 (xx)
ZA (1) ZA9810444B (xx)

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KR20010108316A (ko) 1999-03-05 2001-12-07 데이비드 엠 모이어 Ｃ16 불포화된 ｆｐ-선택적 프로스타글란딘 유사체
EP1354588A1 (en) * 1999-03-18 2003-10-22 United Therapeutics Corporation et al Method for delivering benzindene prostaglandind by inhalation
ES2296613T3 (es) * 1999-03-18 2008-05-01 Queen Mary And Westfield College Inhibidores de la sintesis de endotelina-1.
US6521212B1 (en) * 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
US7417070B2 (en) * 2003-05-22 2008-08-26 United Therapeutics Corporation Compounds and methods for delivery of prostacyclin analogs
CA2549801C (en) * 2003-12-16 2012-10-16 United Therapeutics Corporation Use of treprostinil to improve kidney functions
US20090124697A1 (en) * 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
US8765813B2 (en) 2003-12-16 2014-07-01 United Therapeutics Corporation Use of treprostinil to treat and prevent ischemic lesions
KR101186029B1 (ko) * 2004-04-12 2012-09-27 유나이티드 쎄러퓨틱스 코포레이션 신경병증성 당뇨병성 족부 궤양을 치료하기 위한트레프로스티닐의 용도
US8747897B2 (en) 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
CA2654492C (en) 2006-05-15 2017-06-27 United Therapeutics Corporation Treprostinil administration using a metered dose inhaler
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
CA2678258A1 (en) * 2007-02-09 2008-08-14 United Therapeutics Corporation Treprostinil treatment for interstitial lung disease and asthma
EP2252570B1 (en) 2007-12-17 2017-04-05 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin ®
KR100989093B1 (ko) 2008-01-18 2010-10-25 한화제약주식회사 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물
CA2723540C (en) 2008-05-08 2016-01-05 United Therapeutics Corporation Treprostinil monohydrate
EP2427054A4 (en) * 2009-05-07 2014-01-15 United Therapeutics Corp SOLID COMPOSITIONS BASED ON PROSTACYCLINE ANALOGS
CN102883722B (zh) 2010-03-15 2014-11-05 联合治疗公司 用于肺动脉高血压的治疗
KR101868166B1 (ko) 2010-06-03 2018-06-15 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐의 제조
CN103476762B (zh) 2011-03-02 2015-04-22 联合治疗公司 用于生产曲前列环素的中间体的合成
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CA2905720C (en) 2013-03-14 2021-10-19 United Therapeutics Corporation Solid forms of treprostinil
CA2904598C (en) 2013-03-15 2021-10-05 United Therapeutics Corporation Salts of treprostinil
US9102660B2 (en) 2013-03-25 2015-08-11 United Therapeutics Corporaiton Process of making prostacyclin compounds with linker thiol and pegylated forms
BR112016009207B1 (pt) 2013-10-25 2022-11-22 Insmed Incorporated Compostos de prostaciclina
US20170095432A1 (en) 2014-06-13 2017-04-06 United Therapeutics Corporation Treprostinil formulations
HU231184B1 (hu) 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
JP6224872B1 (ja) 2014-10-20 2017-11-01 ユナイテッド セラピューティクス コーポレイション プロスタサイクリン誘導体を生成するための中間体の合成
CA2967385C (en) 2014-11-18 2023-05-16 Insmed Incorporated Methods of manufacturing treprostinil and treprostinil derivative prodrugs
US10632129B2 (en) 2014-12-03 2020-04-28 Steadymed Ltd. Preservative-free treprostinil formulations and methods and devices for use with same
US20180153847A1 (en) 2016-09-26 2018-06-07 United Therapeutics Corporation Treprostinil prodrugs
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
JP7455144B2 (ja) 2019-04-29 2024-03-25 インスメッド インコーポレイテッド トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法
JP2022546314A (ja) 2019-08-23 2022-11-04 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
JP2023523557A (ja) 2020-04-17 2023-06-06 ユナイテッド セラピューティクス コーポレイション 間質性肺疾患の治療における使用のためのトレプロスチニル
US11793780B2 (en) 2020-06-09 2023-10-24 United Therapeutics Corporation Prodrugs of treprosiinil
CA3202061A1 (en) 2020-12-14 2022-06-23 Kenneth Robert Phares Methods of treating disease with treprostinil prodrugs
JP2024510930A (ja) 2021-03-03 2024-03-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物
US20230263807A1 (en) 2022-02-08 2023-08-24 United Therapeutics Corporation Treprostinil iloprost combination therapy
US20240287105A1 (en) 2023-01-19 2024-08-29 United Therapeutics Corporation Treprostinil analogs and related methods of making and using

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DE3315356A1 (de) * 1982-04-30 1983-11-17 Ono Pharmaceutical Co. Ltd., Osaka Verwendung von prostaglandinanalogen
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
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Also Published As

Publication number Publication date
CA2312729C (en) 2006-05-23
CA2312729A1 (en) 1999-05-27
AU1373499A (en) 1999-06-07
ATE262336T1 (de) 2004-04-15
JP3701870B2 (ja) 2005-10-05
DE69822665D1 (de) 2004-04-29
WO1999025357A1 (en) 1999-05-27
EP1045695B1 (en) 2004-03-24
JP2001522892A (ja) 2001-11-20
JP2005225877A (ja) 2005-08-25
KR100638684B1 (ko) 2006-10-27
KR20010015807A (ko) 2001-02-26
US6054486A (en) 2000-04-25
CN1285748A (zh) 2001-02-28
CN1142781C (zh) 2004-03-24
DE69822665T2 (de) 2005-02-17
ES2214753T3 (es) 2004-09-16
EP1045695A1 (en) 2000-10-25

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