ZA9810444B - Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease - Google Patents

Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease

Info

Publication number
ZA9810444B
ZA9810444B ZA9810444A ZA9810444A ZA9810444B ZA 9810444 B ZA9810444 B ZA 9810444B ZA 9810444 A ZA9810444 A ZA 9810444A ZA 9810444 A ZA9810444 A ZA 9810444A ZA 9810444 B ZA9810444 B ZA 9810444B
Authority
ZA
South Africa
Prior art keywords
interphenylene
trinor
methano
deoxy
oxa
Prior art date
Application number
ZA9810444A
Other languages
English (en)
Inventor
James W Crow
Shelmer D Blackburn Jr
Robert Roscigno
Michael Wade
Gilles Cloutier
Martine Rothblatt
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of ZA9810444B publication Critical patent/ZA9810444B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
ZA9810444A 1997-11-14 1998-11-16 Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease ZA9810444B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6604997P 1997-11-14 1997-11-14

Publications (1)

Publication Number Publication Date
ZA9810444B true ZA9810444B (en) 1999-06-24

Family

ID=22066941

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9810444A ZA9810444B (en) 1997-11-14 1998-11-16 Use of 9-deoxy-2',9-methano-3-oxa-4,5,6-trinor-3,7-(1',3'interphenylene)-13,14-dihydroprostaglandin F1 to treat peripheral vascular disease

Country Status (12)

Country Link
US (1) US6054486A (de)
EP (1) EP1045695B1 (de)
JP (2) JP3701870B2 (de)
KR (1) KR100638684B1 (de)
CN (1) CN1142781C (de)
AT (1) ATE262336T1 (de)
AU (1) AU1373499A (de)
CA (1) CA2312729C (de)
DE (1) DE69822665T2 (de)
ES (1) ES2214753T3 (de)
WO (1) WO1999025357A1 (de)
ZA (1) ZA9810444B (de)

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EP1159266B1 (de) 1999-03-05 2004-11-03 Duke University C-16 ungesätigte fp-selektive prostaglandin analoge
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EP1354588A1 (de) * 1999-03-18 2003-10-22 United Therapeutics Corporation et al Verfahren zur Abgabe von Benzidenprostaglandin durch Inhalation
AU3934000A (en) * 1999-03-18 2000-10-04 United Therapeutics Corporation Inhibitors of endothelin-1 synthesis
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
CN101780092B (zh) 2003-05-22 2012-07-04 联合治疗公司 化合物和释放前列环素类似物的方法
KR20060123482A (ko) * 2003-12-16 2006-12-01 유나이티드 쎄러퓨틱스 코포레이션 신장 기능을 개선하기 위한 트레프로스티닐의 용도
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
WO2005058303A1 (en) * 2003-12-16 2005-06-30 United Therapeutics Corporation Use of treprostinil to treat and prevent ischemic lesions
ES2340939T3 (es) 2004-04-12 2010-06-11 United Therapeutics Corporation Utilizacioin del treprostinil para tratar las ulceras de pie diabeticas neuropaticas.
US8747897B2 (en) 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
CN101495122B (zh) 2006-05-15 2011-10-05 联合治疗公司 使用定量吸入器给予曲前列尼
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
EP2120961A1 (de) * 2007-02-09 2009-11-25 United Therapeutics Corporation Treprostinil-behandlung für interstitielle lungenerkrankungen und asthma
KR101614465B1 (ko) 2007-12-17 2016-04-21 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
KR100989093B1 (ko) 2008-01-18 2010-10-25 한화제약주식회사 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물
US8350079B2 (en) * 2008-05-08 2013-01-08 United Therapeutics Corporation Treprostinil formulation
KR101544246B1 (ko) * 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제
ES2611187T3 (es) 2010-03-15 2017-05-05 United Therapeutics Corporation Tratamiento para hipertensión pulmonar
US8481782B2 (en) 2010-06-03 2013-07-09 United Therapeutics Corporation Treprostinil production
US8461393B2 (en) 2011-03-02 2013-06-11 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
EP2970091A4 (de) 2013-03-14 2017-02-08 United Therapeutics Corporation Feste formen von treprostinil
WO2014150203A1 (en) 2013-03-15 2014-09-25 United Therapeutics Corporation Salts of treprostinil
JP6263604B2 (ja) 2013-03-25 2018-01-17 ユナイテッド セラピューティクス コーポレイション チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
PT3060041T (pt) 2013-10-25 2021-03-12 Insmed Inc Compostos de prostaciclina
WO2015192030A1 (en) 2014-06-13 2015-12-17 United Therapeutics Corporation Treprostinil formulations
HU231184B1 (hu) 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
ES2873873T3 (es) 2014-11-18 2021-11-04 Insmed Inc Métodos de fabricación de treprostinilo y profármacos derivados de treprostinilo
CA2967899C (en) 2014-12-03 2023-09-19 Steadymed Ltd Preservative-free treprostinil formulations and methods and devices for use with same
WO2018058124A1 (en) 2016-09-26 2018-03-29 United Therapeutics Corporation Treprostinil prodrugs
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
BR112021021775A2 (pt) 2019-04-29 2022-01-04 Insmed Inc Composições de pó seco de pró-fármacos de treprostinil e métodos de uso destas
CA3149358A1 (en) 2019-08-23 2021-03-04 United Therapeutics Corporation Treprostinil prodrugs
EP4135707A1 (de) 2020-04-17 2023-02-22 United Therapeutics Corporation Treprostinil zur verwendung bei der behandlung von intersitiellen lungenerkrankungen
CA3180230A1 (en) 2020-06-09 2021-12-16 Hitesh Batra Fumaryl diketopiperidine prodrugs of treprostinil
CA3202061A1 (en) 2020-12-14 2022-06-23 Kenneth Robert Phares Methods of treating disease with treprostinil prodrugs
WO2022187352A1 (en) 2021-03-03 2022-09-09 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
US20230263807A1 (en) 2022-02-08 2023-08-24 United Therapeutics Corporation Treprostinil iloprost combination therapy
WO2024155752A1 (en) 2023-01-19 2024-07-25 United Therapeutics Corporation Treprostinil analogs

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DE3315356A1 (de) * 1982-04-30 1983-11-17 Ono Pharmaceutical Co. Ltd., Osaka Verwendung von prostaglandinanalogen
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
SU1236380A1 (ru) * 1983-07-21 1986-06-07 Областная Клиническая Больница Г.Калинина Способ прогнозировани течени облитерирующего атеросклероза нижней конечности
GB8814438D0 (en) * 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
DE4135193C1 (de) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De

Also Published As

Publication number Publication date
CN1285748A (zh) 2001-02-28
CA2312729A1 (en) 1999-05-27
KR100638684B1 (ko) 2006-10-27
AU1373499A (en) 1999-06-07
ATE262336T1 (de) 2004-04-15
CA2312729C (en) 2006-05-23
CN1142781C (zh) 2004-03-24
JP2005225877A (ja) 2005-08-25
EP1045695A1 (de) 2000-10-25
JP3701870B2 (ja) 2005-10-05
WO1999025357A1 (en) 1999-05-27
DE69822665T2 (de) 2005-02-17
ES2214753T3 (es) 2004-09-16
EP1045695B1 (de) 2004-03-24
JP2001522892A (ja) 2001-11-20
KR20010015807A (ko) 2001-02-26
US6054486A (en) 2000-04-25
DE69822665D1 (de) 2004-04-29

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