ZA976138B - Asymmetric synthesis of chiral beta-amino acids - Google Patents

Asymmetric synthesis of chiral beta-amino acids

Info

Publication number
ZA976138B
ZA976138B ZA976138A ZA976138A ZA976138B ZA 976138 B ZA976138 B ZA 976138B ZA 976138 A ZA976138 A ZA 976138A ZA 976138 A ZA976138 A ZA 976138A ZA 976138 B ZA976138 B ZA 976138B
Authority
ZA
South Africa
Prior art keywords
amino
trimethylsilyl
pentynoate
dimethylethyl
produce
Prior art date
Application number
ZA976138A
Other languages
English (en)
Inventor
James R Behling
Mark L Boys
Kimberly J Cain-Janicki
Pierre-Jean Colson
Wendel W Doubleday
Joseph E Duran
Payman N Farid
Cari M Knable
Frank W Muellner
Sean T Nugent
Ravindra S Topgi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA976138B publication Critical patent/ZA976138B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA976138A 1996-07-12 1997-07-10 Asymmetric synthesis of chiral beta-amino acids ZA976138B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2163196P 1996-07-12 1996-07-12

Publications (1)

Publication Number Publication Date
ZA976138B true ZA976138B (en) 1998-07-10

Family

ID=21805290

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA976138A ZA976138B (en) 1996-07-12 1997-07-10 Asymmetric synthesis of chiral beta-amino acids

Country Status (15)

Country Link
US (1) US5840961A (xx)
EP (1) EP0912495B1 (xx)
JP (1) JP2000514809A (xx)
CN (1) CN1119321C (xx)
AT (1) ATE209179T1 (xx)
AU (1) AU3586097A (xx)
CA (1) CA2258712C (xx)
DE (1) DE69709742T2 (xx)
DK (1) DK0912495T3 (xx)
ES (1) ES2167758T3 (xx)
HK (1) HK1019874A1 (xx)
PT (1) PT912495E (xx)
TW (1) TW404936B (xx)
WO (1) WO1998002410A1 (xx)
ZA (1) ZA976138B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001523969A (ja) * 1997-05-01 2001-11-27 ジー.ディー.サール アンド カンパニー キラルベータアミノ酸の製造方法および製造装置
ZA991105B (en) * 1998-03-04 2000-02-11 Searle & Co Synthesis of chiral beta-amino acids.
WO2000038730A2 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia
MXPA01009617A (es) 1999-03-22 2003-07-21 Johnson & Johnson Sisntesis de propanoatos de 3-amino-3-arilo.
JP2002540108A (ja) 1999-03-22 2002-11-26 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド [S−(R*,S*)]−β−[[[1−[1−オキソ−3−(4−ピペリジニル)プロピル]−3−ピペリジニル]カルボニル]アミノ]−3−ピリジンプロパン酸及び誘導体を製造する方法
CN1362948A (zh) 1999-03-22 2002-08-07 奥索-麦克尼尔药品公司 3s-3-氨基-3-芳基丙酸及其衍生物的制备方法
NL1013789C2 (nl) * 1999-12-08 2001-06-12 Dsm Nv Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen.
DE60036222T2 (de) * 1999-12-08 2008-09-04 Dsm Ip Assets B.V. Verfahren zur herstellung von enantiomeren angereicherten verbindungen
US6586612B2 (en) * 2001-11-16 2003-07-01 Crompton Corporation Process for the preparation of secondary and tertiary amino-functional silanes, iminoorganosilanes and/or imidoorganosilanes
CN100588649C (zh) * 2002-01-10 2010-02-10 武田药品工业株式会社 制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
MXPA06003396A (es) * 2003-09-25 2006-06-08 Warner Lambert Co Profarmacos de aminoacidos con afinidad por la proteina a 2d.
WO2006069798A1 (en) * 2004-12-28 2006-07-06 Dsm Ip Assets B.V. Process for the preparation of chiral amines
FR2969604B1 (fr) * 2010-12-23 2013-01-18 Diverchim Procede de preparation d'acides amines chiraux
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
MX2015000794A (es) 2012-07-18 2015-10-12 Univ Saint Louis Derivados de aminoácido beta como antagonistas de integrina.
CN108779077A (zh) 2015-12-30 2018-11-09 圣路易斯大学 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5536869A (en) * 1995-07-14 1996-07-16 G. D. Searle & Co. Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate

Also Published As

Publication number Publication date
US5840961A (en) 1998-11-24
CA2258712C (en) 2008-01-08
TW404936B (en) 2000-09-11
CN1225084A (zh) 1999-08-04
DK0912495T3 (da) 2002-05-21
WO1998002410A1 (en) 1998-01-22
PT912495E (pt) 2002-04-29
CA2258712A1 (en) 1998-01-22
DE69709742T2 (de) 2002-08-08
HK1019874A1 (en) 2000-03-03
DE69709742D1 (de) 2002-02-21
EP0912495B1 (en) 2001-11-21
CN1119321C (zh) 2003-08-27
EP0912495A1 (en) 1999-05-06
ES2167758T3 (es) 2002-05-16
ATE209179T1 (de) 2001-12-15
AU3586097A (en) 1998-02-09
JP2000514809A (ja) 2000-11-07

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