ES8706142A1 - Un procedimiento para la preparacion de sorbinil - Google Patents
Un procedimiento para la preparacion de sorbinilInfo
- Publication number
- ES8706142A1 ES8706142A1 ES551962A ES551962A ES8706142A1 ES 8706142 A1 ES8706142 A1 ES 8706142A1 ES 551962 A ES551962 A ES 551962A ES 551962 A ES551962 A ES 551962A ES 8706142 A1 ES8706142 A1 ES 8706142A1
- Authority
- ES
- Spain
- Prior art keywords
- sorbinil
- intermediates
- processes
- benzyloxycarbonyl
- chiral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Liquid Crystal Substances (AREA)
Abstract
METODO DE PREPARAR SORBINIL. CONSISTE EN HACER REACCIONAR S-6-FLUOR-4-AMINOCROMAN-4-CARBOXAMIDA CON UN EQUIVALENTE DE UN COMPUESTO DE FORMULA (I), DONDE X E Y SON 1-IMIDAZOLILO O CLORO, TRICLOROMETOXI, ALCOXI DE C 1 A 5, FENOXI O BENCILOXI, EN PRESENCIA DE UN EQUIVALENTE DE UNA BASE FUERTE CUANDO X E Y SON DISTINTOS DE CLORO, Y BASE SUFICIENTE PARA NEUTRALIZAR CUALQUIER HCL CO-PRODUCIDO CUANDO X O Y SON AMBOS CLORO. LA REACCION SE LLEVA A CABO A UNA TEMPERATURA ENTRE 50 Y 100JC, EN UN DISOLVENTE TAL COMO UN ALCANOL DE C 1 A 5, SIENDO LA BASE UN ALCOXIDO DE C 1 A 5. TIENEN UTILIDADES FARMACEUTICAS PARA EL TRATAMIENTO DE LA DIABETES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/643,895 US4620019A (en) | 1984-08-23 | 1984-08-23 | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES551962A0 ES551962A0 (es) | 1987-06-01 |
| ES8706142A1 true ES8706142A1 (es) | 1987-06-01 |
Family
ID=24582609
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546343A Expired ES8700260A1 (es) | 1984-08-23 | 1985-08-22 | Un procedimiento para la preparcion de sorbonil. |
| ES551961A Expired ES8706141A1 (es) | 1984-08-23 | 1986-02-13 | Un procedimiento para la preparacion de sorbinil |
| ES551962A Expired ES8706142A1 (es) | 1984-08-23 | 1986-02-13 | Un procedimiento para la preparacion de sorbinil |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546343A Expired ES8700260A1 (es) | 1984-08-23 | 1985-08-22 | Un procedimiento para la preparcion de sorbonil. |
| ES551961A Expired ES8706141A1 (es) | 1984-08-23 | 1986-02-13 | Un procedimiento para la preparacion de sorbinil |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4620019A (es) |
| EP (1) | EP0173522B1 (es) |
| JP (1) | JPS6157575A (es) |
| KR (1) | KR870000273B1 (es) |
| CN (1) | CN1004074B (es) |
| AT (1) | ATE39117T1 (es) |
| AU (1) | AU553838B2 (es) |
| CA (1) | CA1245667A (es) |
| DD (1) | DD240204A5 (es) |
| DE (1) | DE3566670D1 (es) |
| DK (1) | DK380785A (es) |
| ES (3) | ES8700260A1 (es) |
| FI (1) | FI853182L (es) |
| GR (1) | GR852007B (es) |
| HU (1) | HU195660B (es) |
| IL (1) | IL76150A (es) |
| IN (1) | IN165762B (es) |
| NO (1) | NO853305L (es) |
| NZ (1) | NZ213196A (es) |
| PH (1) | PH22577A (es) |
| PL (1) | PL255117A1 (es) |
| PT (1) | PT80996B (es) |
| SU (1) | SU1380613A3 (es) |
| YU (1) | YU43881B (es) |
| ZA (1) | ZA856371B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
| US5072006A (en) * | 1988-12-09 | 1991-12-10 | Recherche Syntex France S.A. | Novel benzopyranylpyrrolinone derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4348526A (en) * | 1980-03-28 | 1982-09-07 | Pfizer Inc. | Intermediates in the preparation of chiral hydantoins |
| US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
| US4431828A (en) * | 1982-11-10 | 1984-02-14 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil |
| US4435578A (en) * | 1982-11-10 | 1984-03-06 | Pfizer Inc. | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid |
| DE3367103D1 (en) * | 1982-11-10 | 1986-11-27 | Pfizer | Sorbinil by optical resolution with aminopinane derivatives |
-
1984
- 1984-08-23 US US06/643,895 patent/US4620019A/en not_active Expired - Lifetime
-
1985
- 1985-05-30 IN IN434/DEL/85A patent/IN165762B/en unknown
- 1985-06-19 CN CN85104685.1A patent/CN1004074B/zh not_active Expired
- 1985-06-27 CA CA000485508A patent/CA1245667A/en not_active Expired
- 1985-08-16 EP EP85305838A patent/EP0173522B1/en not_active Expired
- 1985-08-16 AT AT85305838T patent/ATE39117T1/de not_active IP Right Cessation
- 1985-08-16 DE DE8585305838T patent/DE3566670D1/de not_active Expired
- 1985-08-19 GR GR852007A patent/GR852007B/el unknown
- 1985-08-19 FI FI853182A patent/FI853182L/fi not_active Application Discontinuation
- 1985-08-21 DD DD85279859A patent/DD240204A5/de not_active IP Right Cessation
- 1985-08-21 IL IL76150A patent/IL76150A/xx unknown
- 1985-08-21 YU YU1331/85A patent/YU43881B/xx unknown
- 1985-08-21 PT PT80996A patent/PT80996B/pt not_active IP Right Cessation
- 1985-08-22 ZA ZA856371A patent/ZA856371B/xx unknown
- 1985-08-22 DK DK380785A patent/DK380785A/da not_active Application Discontinuation
- 1985-08-22 NO NO853305A patent/NO853305L/no unknown
- 1985-08-22 PH PH32681A patent/PH22577A/en unknown
- 1985-08-22 AU AU46547/85A patent/AU553838B2/en not_active Ceased
- 1985-08-22 NZ NZ213196A patent/NZ213196A/en unknown
- 1985-08-22 ES ES546343A patent/ES8700260A1/es not_active Expired
- 1985-08-22 SU SU853942404A patent/SU1380613A3/ru active
- 1985-08-22 KR KR1019850006045A patent/KR870000273B1/ko not_active IP Right Cessation
- 1985-08-22 HU HU853200A patent/HU195660B/hu not_active IP Right Cessation
- 1985-08-23 PL PL25511785A patent/PL255117A1/xx unknown
- 1985-08-23 JP JP60185618A patent/JPS6157575A/ja active Pending
-
1986
- 1986-02-13 ES ES551961A patent/ES8706141A1/es not_active Expired
- 1986-02-13 ES ES551962A patent/ES8706142A1/es not_active Expired
- 1986-02-14 US US06/829,250 patent/US4704461A/en not_active Expired - Lifetime
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