ES8708234A1 - Un procedimiento para la preparacion de intermediarios enolsilileter de carbapenem - Google Patents

Un procedimiento para la preparacion de intermediarios enolsilileter de carbapenem

Info

Publication number
ES8708234A1
ES8708234A1 ES554217A ES554217A ES8708234A1 ES 8708234 A1 ES8708234 A1 ES 8708234A1 ES 554217 A ES554217 A ES 554217A ES 554217 A ES554217 A ES 554217A ES 8708234 A1 ES8708234 A1 ES 8708234A1
Authority
ES
Spain
Prior art keywords
carbapenem intermediates
carbapenem
intermediates
methyl
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554217A
Other languages
English (en)
Other versions
ES554217A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8708234A1 publication Critical patent/ES8708234A1/es
Publication of ES554217A0 publication Critical patent/ES554217A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C07F7/16—Preparation thereof from silicon and halogenated hydrocarbons direct synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE SINTESIS DE INTERMEDIARIOS ENOLSILILETER DE CARBAPENEM. CONSISTENTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN TRIFLATO DE SILILO DE FORMULA (III) A UNA TEMPERATURA COMPRENDIDA ENTRE -40GC Y +30GC, EN PRESENCIA DE UNA TRIALQUILAMINA DE C 1 A 4, Y UTILIZANDO CLORURO DE METILENO COMO DISOLVENTE, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R ELEVADO A 1, R CUADRADO Y R CUBO, ALQUILO DE C 1 A 4 Y OTROS; R ELEVADO A 5 Y R ELEVADO A 6, H O METILO; R ELEVADO A 7, UN GRUPO ESTER SELECCIONADO ENTRE ALQUILO DE C 1 A 4, P-NITROBENCENO Y OTROS. SE UTILIZAN COMO INTERMEDIO EN LA SINTESIS DE TIENAMICINA Y OTROS ANTIBIOTICOS DE CARBAPENEM. *FORMULA* T
ES554217A 1985-04-22 1986-04-21 Un procedimiento para la preparacion de intermediarios enolsilileter de carbapenem Expired ES8708234A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/725,594 US4683296A (en) 1983-03-07 1985-04-22 Carbapenem intermediates

Publications (2)

Publication Number Publication Date
ES8708234A1 true ES8708234A1 (es) 1987-10-01
ES554217A0 ES554217A0 (es) 1987-10-01

Family

ID=24915191

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554217A Expired ES8708234A1 (es) 1985-04-22 1986-04-21 Un procedimiento para la preparacion de intermediarios enolsilileter de carbapenem

Country Status (35)

Country Link
US (1) US4683296A (es)
JP (1) JPS61275284A (es)
KR (1) KR890004347B1 (es)
CN (1) CN86102077A (es)
AR (1) AR244236A1 (es)
AT (1) AT386208B (es)
AU (1) AU599022B2 (es)
BE (1) BE904645A (es)
CA (1) CA1302426C (es)
CH (1) CH667273A5 (es)
CS (1) CS266585B2 (es)
DD (1) DD251352A5 (es)
DE (1) DE3613366A1 (es)
DK (1) DK182386A (es)
ES (1) ES8708234A1 (es)
FI (1) FI861633A (es)
FR (1) FR2580653B1 (es)
GB (1) GB2173801B (es)
GR (1) GR861064B (es)
HU (1) HU195824B (es)
IE (1) IE59042B1 (es)
IL (1) IL78533A (es)
IT (1) IT1213061B (es)
LU (1) LU86401A1 (es)
MY (1) MY102926A (es)
NL (1) NL8601010A (es)
NO (1) NO861558L (es)
NZ (1) NZ215263A (es)
OA (1) OA08235A (es)
PT (1) PT82435B (es)
SE (1) SE8601824L (es)
YU (1) YU43696B (es)
ZA (1) ZA862987B (es)
ZM (1) ZM6286A1 (es)
ZW (1) ZW8986A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772683A (en) * 1986-02-24 1988-09-20 Bristol-Myers Company High percentage beta-yield synthesis of carbapenem intermediates
JP2675625B2 (ja) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 エノールシリルエーテル化合物の製造方法
US5340927A (en) * 1989-07-18 1994-08-23 Merck & Co., Inc. Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE4014649A1 (de) * 1990-05-08 1991-11-14 Hoechst Ag Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
JP2000166962A (ja) * 1998-12-08 2000-06-20 Tatsu Ifukube 触覚刺激装置及び方法
ES2335889T3 (es) 2003-08-28 2010-04-06 Ranbaxy Laboratories Limited Proceso para la preparacion de esteres de acido 2-diazo-3-trimetilsililoxi-3-butenoico.
US20070037971A1 (en) * 2005-07-29 2007-02-15 Meeran Hashim Nizar P N Process for desilylation of carbapenem intermediates
AU2009277936B2 (en) * 2008-07-30 2014-11-27 Sun Pharmaceutical Industries Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CN102690282A (zh) * 2011-07-07 2012-09-26 深圳市海滨制药有限公司 晶体形式的1β甲基碳青霉烯类抗生素中间体及其制备方法
CN102643211A (zh) * 2012-04-10 2012-08-22 平顶山佳瑞高科实业有限公司 一种2-重氮乙酰乙酸对硝基苄酯的制备方法
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth
CN106565535B (zh) * 2016-11-15 2018-07-17 山西师范大学 2-重氮-1-芳基酮类化合物的制备方法
CN107556212B (zh) * 2017-09-14 2020-03-24 台州昌霖化工科技有限公司 一种制备2-重氮乙酰乙酸对硝基苄酯的方法
CN114516820A (zh) * 2022-02-25 2022-05-20 山东艾孚特科技有限公司 一种制备2-重氮乙酰乙酸对硝基苄酯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003445A1 (en) * 1981-04-03 1982-10-14 Nagamoto Shunichi Display unit of a cooking apparatus for selectively displaying image signals from several image signal sources
US4444685A (en) * 1981-04-27 1984-04-24 Merck & Co., Inc. Stereospecific synthesis of thienamycin from penicillin
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4525582A (en) * 1982-06-22 1985-06-25 Merck & Co., Inc. Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin
CA1269978A (en) * 1982-09-28 1990-06-05 Choung U. Kim Carbapenem antibiotics
CA1220215A (en) * 1983-03-07 1987-04-07 Yasutsugu Ueda Carbapenem intermediates

Also Published As

Publication number Publication date
IT8620164A0 (it) 1986-04-21
NL8601010A (nl) 1986-11-17
AU5616786A (en) 1986-11-06
YU65886A (en) 1988-04-30
PT82435A (en) 1986-05-01
ATA106886A (de) 1987-12-15
FI861633A0 (fi) 1986-04-17
KR890004347B1 (ko) 1989-10-31
NZ215263A (en) 1989-03-29
IL78533A (en) 1992-05-25
CH667273A5 (de) 1988-09-30
DD251352A5 (de) 1987-11-11
IE59042B1 (en) 1993-12-15
GB8609662D0 (en) 1986-05-29
GB2173801A (en) 1986-10-22
CS266585B2 (en) 1990-01-12
FR2580653B1 (fr) 1989-06-16
DK182386D0 (da) 1986-04-21
ZM6286A1 (en) 1987-04-30
GB2173801B (en) 1989-08-23
LU86401A1 (fr) 1986-11-05
AT386208B (de) 1988-07-25
IE861047L (en) 1986-10-22
CS287386A2 (en) 1989-04-14
DK182386A (da) 1986-10-23
SE8601824L (sv) 1986-10-23
FR2580653A1 (fr) 1986-10-24
JPS6358836B2 (es) 1988-11-17
DE3613366A1 (de) 1986-11-20
BE904645A (fr) 1986-10-21
ZA862987B (en) 1987-12-30
PT82435B (pt) 1988-08-17
MY102926A (en) 1993-03-31
US4683296A (en) 1987-07-28
JPS61275284A (ja) 1986-12-05
KR860008191A (ko) 1986-11-12
YU43696B (en) 1989-10-31
IT1213061B (it) 1989-12-07
SE8601824D0 (sv) 1986-04-21
ES554217A0 (es) 1987-10-01
NO861558L (no) 1986-10-23
HUT41040A (en) 1987-03-30
CN86102077A (zh) 1987-01-28
OA08235A (fr) 1987-10-30
IL78533A0 (en) 1986-08-31
AR244236A1 (es) 1993-10-29
GR861064B (en) 1986-09-01
FI861633A (fi) 1986-10-23
ZW8986A1 (en) 1986-12-03
HU195824B (en) 1988-07-28
CA1302426C (en) 1992-06-02
AU599022B2 (en) 1990-07-12

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