ZA9711317B - Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them. - Google Patents

Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them.

Info

Publication number
ZA9711317B
ZA9711317B ZA9711317A ZA9711317A ZA9711317B ZA 9711317 B ZA9711317 B ZA 9711317B ZA 9711317 A ZA9711317 A ZA 9711317A ZA 9711317 A ZA9711317 A ZA 9711317A ZA 9711317 B ZA9711317 B ZA 9711317B
Authority
ZA
South Africa
Prior art keywords
compositions
processes
preparation
purine derivatives
substituted purine
Prior art date
Application number
ZA9711317A
Other languages
English (en)
Inventor
Anuschriwan Payman
Jochen Knolle
Volkmar Wehner
Gerhard Breiphol
Jean-Francois Gourvest
Denis Carniato
Thomas Richard Gadek
Original Assignee
Hoechst Ag
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag, Genentech Inc filed Critical Hoechst Ag
Publication of ZA9711317B publication Critical patent/ZA9711317B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9711317A 1996-12-20 1997-12-17 Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them. ZA9711317B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19653646A DE19653646A1 (de) 1996-12-20 1996-12-20 Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung

Publications (1)

Publication Number Publication Date
ZA9711317B true ZA9711317B (en) 1998-06-22

Family

ID=7815761

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711317A ZA9711317B (en) 1996-12-20 1997-12-17 Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them.

Country Status (22)

Country Link
EP (1) EP0853084B1 (fr)
JP (1) JP4620190B2 (fr)
KR (1) KR19980064655A (fr)
CN (2) CN1101816C (fr)
AR (1) AR010700A1 (fr)
AT (1) ATE404562T1 (fr)
AU (1) AU728865B2 (fr)
BR (1) BR9706387A (fr)
CA (1) CA2225366C (fr)
CZ (1) CZ294437B6 (fr)
DE (2) DE19653646A1 (fr)
HK (1) HK1012190A1 (fr)
HU (1) HUP9702507A3 (fr)
ID (1) ID19254A (fr)
IL (1) IL122642A0 (fr)
NO (1) NO314583B1 (fr)
NZ (1) NZ329431A (fr)
PL (1) PL323969A1 (fr)
RU (1) RU2228335C2 (fr)
TR (1) TR199701647A2 (fr)
TW (1) TW523515B (fr)
ZA (1) ZA9711317B (fr)

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AU759449C (en) 1998-04-09 2003-10-30 Meiji Seika Pharma Co.,Ltd. Aminopiperidine derivatives as integrin alpha v beta 3 antagonists
DE69930764D1 (de) 1998-12-23 2006-05-18 G D Searle Llc St Louis Verwendung von cyclooxygenase-2 inhibitor celecoxib und capecitabine zur kombinationsbehandlung von neoplasia
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
EP1065208A1 (fr) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Dérivés substitués de la purine inhibiteurs de l'adhésion cellulaire
EP1065207A1 (fr) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Dérivées de la naphthyridine, procédés pour leur preparation, leur utilisation, et compositions pharmaceutique les contenant
AU6316900A (en) 1999-08-05 2001-03-05 Meiji Seika Kaisha Ltd. Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism
EP1176145A1 (fr) * 2000-07-28 2002-01-30 Aventis Pharma Deutschland GmbH Nouveaux dérivés de guanidine et leur utilisation comme inhibiteurs de l'adhésion des cellules
DE10042655A1 (de) 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
KR100438820B1 (ko) * 2001-03-05 2004-07-05 삼성코닝 주식회사 Ιιι-ⅴ족 화합물 반도체 기판의 제조 방법
DK1381384T3 (da) 2001-04-24 2011-07-25 Merck Patent Gmbh Kombinationsterapi under anvendelse af anti-angiogene midler og TNFalfa
FR2847254B1 (fr) * 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) * 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US20090130098A1 (en) 2006-01-18 2009-05-21 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
CA2675813A1 (fr) 2007-01-18 2008-07-24 Merck Patent Gesellschaft Mit Beschraenkter Haftung Therapie specifique et medicament utilisant des ligands d'integrine ou traitant le cancer
WO2009048072A1 (fr) 2007-10-11 2009-04-16 Daiichi Sankyo Company, Limited ANTICORPS CIBLANT LA PROTÉINE Siglec-15 LIÉE AUX OSTÉOCLASTES
NZ586129A (en) * 2007-11-14 2012-06-29 Myrexis Inc Therapeutic compounds and their use in treating diseases and disorders
EP2377932B1 (fr) 2009-04-09 2020-11-18 Daiichi Sankyo Company, Limited Anticorps anti-siglec-15
AU2010252280A1 (en) 2009-05-25 2012-01-19 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
MX2013003828A (es) 2010-10-05 2013-06-28 Daiichi Sankyo Co Ltd Anticuerpo dirigido a la proteina lectina tipo inmunoglobulina de union a acido sialico-15 relacionada con osteoclastos.
CA2868959A1 (fr) 2012-03-30 2013-10-03 Daiichi Sankyo Company, Limited Anticorps anti-siglec15 ayant une cdr modifiee
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
WO2015181676A1 (fr) 2014-05-30 2015-12-03 Pfizer Inc. Dérivés carbonitriles en tant que modulateurs sélectifs du récepteur des androgènes
WO2023275715A1 (fr) 2021-06-30 2023-01-05 Pfizer Inc. Métabolites de modulateurs sélectifs du récepteur des androgènes

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
JPS4730696Y1 (fr) * 1966-12-10 1972-09-13
JPS6396663A (ja) * 1986-10-13 1988-04-27 Mita Ind Co Ltd 静電荷像現像用トナ−
JPS6396553A (ja) * 1986-10-14 1988-04-27 Sekisui Chem Co Ltd 充填剤
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
FR2700337B1 (fr) * 1993-01-11 1995-04-14 Lafon Labor Dérivés d'imidazopyridine-2-one, leur procédé de préparation et leur utilisation en thérapeutique.
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DE4405378A1 (de) * 1994-02-19 1995-08-24 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
US5554746A (en) * 1994-05-16 1996-09-10 Isis Pharmaceuticals, Inc. Lactam nucleic acids
US5929046A (en) * 1994-06-08 1999-07-27 Cancer Research Campaign Technology Limited Pyrimidine and purine derivatives and their use in treating tumour cells
US5994361A (en) * 1994-06-22 1999-11-30 Biochem Pharma Substituted purinyl derivatives with immunomodulating activity
HUT76344A (en) * 1994-06-29 1997-08-28 Smithkline Beecham Corp Vitronectin receptor antagonists
US5525606A (en) * 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
AU4729796A (en) * 1994-12-28 1996-07-19 Peter E. Nielsen Peptide nucleic acid incorporating a chiral backbone
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
WO1996040709A1 (fr) * 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Chimeres anp-adn et synthons d'anp destines a leur preparation
JPH1025294A (ja) * 1996-03-26 1998-01-27 Akira Matsuda 縮合ヘテロ環誘導体、その製造法及びそれを含有する悪性腫瘍治療剤
JP2000507552A (ja) * 1996-03-26 2000-06-20 デュポン ファーマシューティカルズ カンパニー アリールオキシおよびアリールチオ縮合ピリジン、アリールオキシおよびアリールチオ縮合ピリミジン、およびそれらの誘導体
GB9613021D0 (en) * 1996-06-21 1996-08-28 Pharmacia Spa Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
CA2261566A1 (fr) * 1996-07-24 1998-01-29 Buchardt, Dorte Acides nucleiques peptidiques presentant une affinite de fixation, une specificite de sequence et une solubilite accrues
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2

Also Published As

Publication number Publication date
HUP9702507A3 (en) 1999-12-28
EP0853084A3 (fr) 1998-09-09
RU2228335C2 (ru) 2004-05-10
HUP9702507A2 (hu) 1999-05-28
CA2225366C (fr) 2006-10-10
AR010700A1 (es) 2000-06-28
TR199701647A3 (tr) 1998-07-21
PL323969A1 (en) 1998-06-22
CZ294437B6 (cs) 2005-01-12
AU4846697A (en) 1998-06-25
CN1495184A (zh) 2004-05-12
NO975977L (no) 1998-06-22
MX9710277A (es) 1998-10-31
EP0853084A2 (fr) 1998-07-15
AU728865B2 (en) 2001-01-18
EP0853084B1 (fr) 2008-08-13
CN1193623A (zh) 1998-09-23
CA2225366A1 (fr) 1998-06-20
JPH10182645A (ja) 1998-07-07
CN1101816C (zh) 2003-02-19
IL122642A0 (en) 1998-08-16
NO975977D0 (no) 1997-12-19
HU9702507D0 (en) 1998-03-02
JP4620190B2 (ja) 2011-01-26
DE59712958D1 (de) 2008-09-25
DE19653646A1 (de) 1998-06-25
KR19980064655A (ko) 1998-10-07
HK1012190A1 (en) 1999-07-30
TR199701647A2 (xx) 1998-07-21
NO314583B1 (no) 2003-04-14
ATE404562T1 (de) 2008-08-15
ID19254A (id) 1998-06-28
CZ411497A3 (cs) 1998-07-15
TW523515B (en) 2003-03-11
BR9706387A (pt) 2000-03-14
NZ329431A (en) 2000-01-28

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