ZA962075B - Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation. - Google Patents

Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation.

Info

Publication number
ZA962075B
ZA962075B ZA9602075A ZA962075A ZA962075B ZA 962075 B ZA962075 B ZA 962075B ZA 9602075 A ZA9602075 A ZA 9602075A ZA 962075 A ZA962075 A ZA 962075A ZA 962075 B ZA962075 B ZA 962075B
Authority
ZA
South Africa
Prior art keywords
hydrogen
alkylcarbonyl
hydroxy
integer
benzothienylpiperazines
Prior art date
Application number
ZA9602075A
Other languages
English (en)
Inventor
Nicholas J Hrib
John G Jurcak
Abdul E Mutlib
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA962075B publication Critical patent/ZA962075B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9602075A 1995-03-17 1996-03-14 Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation. ZA962075B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41381895A 1995-03-17 1995-03-17

Publications (1)

Publication Number Publication Date
ZA962075B true ZA962075B (en) 1997-12-31

Family

ID=23638775

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9602075A ZA962075B (en) 1995-03-17 1996-03-14 Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation.

Country Status (23)

Country Link
US (1) US5801176A (es)
EP (1) EP0732332B1 (es)
JP (1) JPH093060A (es)
KR (1) KR100402510B1 (es)
CN (1) CN1082959C (es)
AT (1) ATE211137T1 (es)
AU (1) AU700077B2 (es)
CA (1) CA2171695A1 (es)
CZ (1) CZ80496A3 (es)
DE (1) DE69618050T2 (es)
DK (1) DK0732332T3 (es)
ES (1) ES2170177T3 (es)
HU (1) HUP9600665A3 (es)
IL (1) IL117519A (es)
NO (1) NO315652B1 (es)
NZ (1) NZ286186A (es)
PL (1) PL182310B1 (es)
PT (1) PT732332E (es)
RO (1) RO117453B1 (es)
RU (1) RU2157371C2 (es)
SG (1) SG54269A1 (es)
TW (1) TW328957B (es)
ZA (1) ZA962075B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703083A (en) * 1996-04-15 1997-12-30 Neurogen Corporation N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
WO2000078716A1 (fr) * 1999-06-24 2000-12-28 Toray Industries, Inc. ANTAGONISTES DU RECEPTEUR ADRENERGIQUE-α¿1B?
EP1361875A2 (en) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
IL157363A0 (en) * 2001-02-16 2004-02-19 Aventis Pharma Inc Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
GB0117531D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
WO2002078669A1 (fr) * 2001-03-30 2002-10-10 Takeda Chemical Industries, Ltd. Solutions medicinales
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
CN105985314A (zh) * 2015-02-05 2016-10-05 苏州旺山旺水生物医药有限公司 布瑞哌唑类似物的制备方法
EP4082616A4 (en) * 2019-12-24 2024-01-03 Sumitomo Pharma Co., Ltd. AMIDE DERIVATIVE OF ALIPHATIC ACID

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
PL313251A1 (en) 1996-09-30
TW328957B (en) 1998-04-01
CN1082959C (zh) 2002-04-17
ES2170177T3 (es) 2002-08-01
KR960034201A (ko) 1996-10-22
HU9600665D0 (en) 1996-05-28
HUP9600665A3 (en) 1998-08-28
NO315652B1 (no) 2003-10-06
CN1139108A (zh) 1997-01-01
EP0732332B1 (en) 2001-12-19
HUP9600665A2 (en) 1997-10-28
US5801176A (en) 1998-09-01
EP0732332A1 (en) 1996-09-18
NZ286186A (en) 1997-07-27
SG54269A1 (en) 1998-11-16
NO961077L (no) 1996-09-18
NO961077D0 (no) 1996-03-15
AU700077B2 (en) 1998-12-17
DE69618050D1 (de) 2002-01-31
DE69618050T2 (de) 2002-07-11
AU4811396A (en) 1996-09-26
IL117519A (en) 2000-08-31
RO117453B1 (ro) 2002-03-29
PL182310B1 (pl) 2001-12-31
PT732332E (pt) 2002-06-28
ATE211137T1 (de) 2002-01-15
JPH093060A (ja) 1997-01-07
CZ80496A3 (en) 1996-10-16
CA2171695A1 (en) 1996-09-18
IL117519A0 (en) 1996-07-23
KR100402510B1 (ko) 2004-03-18
DK0732332T3 (da) 2002-04-15
RU2157371C2 (ru) 2000-10-10

Similar Documents

Publication Publication Date Title
PH23607A (en) Amide derivatives and pharmaceutical composition containing said compounds
IL110151A0 (en) Amide and urea derivatives and pharmaceutical compositions containing the same
GR3026318T3 (en) N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments
EP1035123A4 (en) NEW HETEROCYCLIC COMPOUNDS
ZA935276B (en) 3-(hydroxybenzylidenyl)-indolin-2-ones processes for their preparation and pharmaceutical compositions containing them
MXPA00006605A (es) Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
MY114548A (en) New arylglycineamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
IL107961A0 (en) Phenoxy- and phenoxyalkyl-piperidines and pharmaceutical compositions containing them
GB9305295D0 (en) Therapeutic compounds
HU9600665D0 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
ZA89389B (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
HUT46536A (en) Process for producing antianxietive pharmaceutical compositions
GR3034023T3 (en) Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
DE69821815D1 (de) Thiocolchicin-Derivate mit entzündungshemmender und muskelrelaxierender Wirkung
DE3787844D1 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
HUT50354A (en) Process for producing new s-adenosylmethionine decarboxilase inhibitors
IL103595A0 (en) 2-heterocyclicethylamine derivatives,their preparation and pharmaceutical compositions containing them
EP1142883A4 (en) HETEROCYCLIC COMPOUNDS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM
AU625238B2 (en) Anti-psychotic piperidylbenzimidazole compounds
IL78780A (en) 1,3-oxathiane-4-phenyl-5-alkenyl derivatives,their preparation and pharmaceutical compositions containing them
GR3017280T3 (en) Aminoalkylchromones, process for their preparation and compositions containing them.
DE69226443D1 (de) N-(mercaptoacyl)aminosäure, ihre herstellung, ihre therapeutische verwendung und sie enthaltende pharmazeutische zusammensetzungen
IE890161L (en) 2-Amino Acetamide Derivatives