ZA95521B - Watersoluble azole antifungals - Google Patents

Watersoluble azole antifungals

Info

Publication number
ZA95521B
ZA95521B ZA95521A ZA95521A ZA95521B ZA 95521 B ZA95521 B ZA 95521B ZA 95521 A ZA95521 A ZA 95521A ZA 95521 A ZA95521 A ZA 95521A ZA 95521 B ZA95521 B ZA 95521B
Authority
ZA
South Africa
Prior art keywords
hydrogen
6alkyl
pct
image
watersoluble
Prior art date
Application number
ZA95521A
Other languages
English (en)
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Luc Alfons Leo Van Der Eycken
Frank Christopher Odds
Jean Louis Mesens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA95521B publication Critical patent/ZA95521B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Detergent Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ZA95521A 1994-01-24 1995-01-23 Watersoluble azole antifungals ZA95521B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18535294A 1994-01-24 1994-01-24

Publications (1)

Publication Number Publication Date
ZA95521B true ZA95521B (en) 1996-07-23

Family

ID=22680644

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA95521A ZA95521B (en) 1994-01-24 1995-01-23 Watersoluble azole antifungals

Country Status (31)

Country Link
US (1) US5707977A (cs)
EP (1) EP0741737B1 (cs)
JP (1) JP3764750B2 (cs)
KR (1) KR100352147B1 (cs)
CN (1) CN1078210C (cs)
AT (1) ATE186540T1 (cs)
AU (1) AU688455B2 (cs)
CA (1) CA2179640C (cs)
CY (1) CY2176B1 (cs)
CZ (1) CZ288544B6 (cs)
DE (1) DE69513279T2 (cs)
DK (1) DK0741737T3 (cs)
ES (1) ES2141329T3 (cs)
FI (1) FI116057B (cs)
GR (1) GR3032550T3 (cs)
HU (1) HU227281B1 (cs)
IL (1) IL112413A (cs)
LV (1) LV12634B (cs)
MY (1) MY111814A (cs)
NO (1) NO308412B1 (cs)
NZ (1) NZ278882A (cs)
PH (1) PH31664A (cs)
PL (1) PL181947B1 (cs)
PT (1) PT741737E (cs)
RU (1) RU2156764C2 (cs)
SG (1) SG48386A1 (cs)
SI (1) SI0741737T1 (cs)
SK (1) SK282059B6 (cs)
TW (1) TW376385B (cs)
WO (1) WO1995019983A1 (cs)
ZA (1) ZA95521B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
WO1996038443A1 (en) * 1995-06-02 1996-12-05 Schering Corporation Tetrahydrofuran antifungals
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
AU6257396A (en) * 1995-06-19 1997-01-15 Schering Corporation Tetrahydrofuran antifungals
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
CN1237172A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,r,s-和2s,4r,r,s-羟基伊曲康唑-和羟基沙波康唑衍生物
JP2001504465A (ja) 1996-11-12 2001-04-03 セプラコール,インク. 2r,4s,s,s―および2s,4r,s,s―ヒドロキシイトラコナゾール
EP0942907A1 (en) * 1996-11-12 1999-09-22 Sepracor, Inc. 2r, 4s, s, r- and 2s, 4r, s, r-hydroxyitraconazole
WO1998021205A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole
ATE270290T1 (de) * 1997-02-11 2004-07-15 Janssen Pharmaceutica Nv Azole enthaltende antifungale aminosäure-ester
CN100343249C (zh) * 1997-07-11 2007-10-17 詹森药业有限公司 2,4,4-三取代的1,3-二氧环戊烷抗真菌剂
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
WO1999018097A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal polymorph
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
WO2000030655A1 (en) * 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
JP2012502028A (ja) * 2008-09-08 2012-01-26 ウ,ニアン トリアゾール抗真菌剤
RU2563811C1 (ru) * 2014-08-08 2015-09-20 Федеральное государственное бюджетное учреждение науки Институт химической физики им. Н.Н. Семенова Российской академии наук (ИХФ РАН) Фармацевтическая композиция для лечения грибковых заболеваний
CN106243087B (zh) * 2016-09-12 2018-10-09 三峡大学 一种三唑吡咯烷酮类杀菌剂,合成方法及其应用
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
DK0736030T3 (da) * 1993-12-21 2001-10-29 Schering Corp Fungicide tetrahydrofuraner

Also Published As

Publication number Publication date
IL112413A0 (en) 1995-03-30
SI0741737T1 (en) 2000-02-29
AU1535595A (en) 1995-08-08
DE69513279D1 (de) 1999-12-16
JP3764750B2 (ja) 2006-04-12
GR3032550T3 (en) 2000-05-31
CZ195696A3 (en) 1997-02-12
HUT75943A (en) 1997-05-28
WO1995019983A1 (en) 1995-07-27
PT741737E (pt) 2000-04-28
EP0741737B1 (en) 1999-11-10
EP0741737A1 (en) 1996-11-13
IL112413A (en) 1999-11-30
CN1078210C (zh) 2002-01-23
NO308412B1 (no) 2000-09-11
ES2141329T3 (es) 2000-03-16
LV12634A (lv) 2001-03-20
HU9602008D0 (en) 1996-09-30
CA2179640C (en) 2005-11-15
MY111814A (en) 2001-01-31
HU227281B1 (en) 2011-01-28
NO963073L (no) 1996-07-23
PL181947B1 (en) 2001-10-31
FI962947A (fi) 1996-07-23
ATE186540T1 (de) 1999-11-15
PL315558A1 (en) 1996-11-12
RU2156764C2 (ru) 2000-09-27
TW376385B (en) 1999-12-11
NZ278882A (en) 1997-06-24
LV12634B (en) 2001-07-20
PH31664A (en) 1999-01-12
AU688455B2 (en) 1998-03-12
JPH09508360A (ja) 1997-08-26
CA2179640A1 (en) 1995-07-27
KR100352147B1 (ko) 2002-11-11
CY2176B1 (en) 2002-08-23
DK0741737T3 (da) 2000-05-22
US5707977A (en) 1998-01-13
SK89696A3 (en) 1998-02-04
CN1138862A (zh) 1996-12-25
DE69513279T2 (de) 2000-07-13
SG48386A1 (en) 1998-04-17
FI116057B (fi) 2005-09-15
CZ288544B6 (cs) 2001-07-11
FI962947A0 (fi) 1996-07-23
NO963073D0 (no) 1996-07-23
SK282059B6 (sk) 2001-10-08

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