ZA954990B - Interleukin-5 specific recombinant antibodies - Google Patents

Interleukin-5 specific recombinant antibodies

Info

Publication number
ZA954990B
ZA954990B ZA954990A ZA954990A ZA954990B ZA 954990 B ZA954990 B ZA 954990B ZA 954990 A ZA954990 A ZA 954990A ZA 954990 A ZA954990 A ZA 954990A ZA 954990 B ZA954990 B ZA 954990B
Authority
ZA
South Africa
Prior art keywords
interleukin
recombinant antibodies
specific recombinant
specific
heavy
Prior art date
Application number
ZA954990A
Other languages
English (en)
Inventor
Mark William Bodmer
Diljeet Singh Athwal
John Spencer Emtage
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Publication of ZA954990B publication Critical patent/ZA954990B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA954990A 1994-06-17 1995-06-15 Interleukin-5 specific recombinant antibodies ZA954990B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9412230A GB9412230D0 (en) 1994-06-17 1994-06-17 Interleukin-5 specific recombiant antibodies

Publications (1)

Publication Number Publication Date
ZA954990B true ZA954990B (en) 1996-12-17

Family

ID=10756925

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954990A ZA954990B (en) 1994-06-17 1995-06-15 Interleukin-5 specific recombinant antibodies

Country Status (18)

Country Link
US (3) US5998586A (no)
EP (1) EP0765392B1 (no)
JP (1) JP3973682B2 (no)
AT (1) ATE264389T1 (no)
AU (1) AU694783B2 (no)
CA (1) CA2192543C (no)
CZ (1) CZ292295B6 (no)
DE (1) DE69532889T2 (no)
ES (1) ES2218546T3 (no)
FI (1) FI965032A (no)
GB (1) GB9412230D0 (no)
HU (1) HU221641B1 (no)
IL (1) IL114179A (no)
NO (1) NO964808L (no)
NZ (1) NZ287927A (no)
SK (1) SK282625B6 (no)
WO (1) WO1995035375A1 (no)
ZA (1) ZA954990B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412230D0 (en) * 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies
USRE39548E1 (en) 1994-06-17 2007-04-03 Celltech R&D Limited Interleukin-5 specific recombinant antibodies
PL194312B1 (pl) * 1994-12-23 2007-05-31 Smithkline Beecham Corp Przeciwciało monoklonalne neutralizujące gryzoni,linia hybrydoma, humanizowane przeciwciało, region CDR ciężkiego łańcucha immunoglobuliny, region CDR lekkiego łańcucha immunoglobuliny, cząsteczki kwasu nukleinowego, przeciwciało chimeryczne, kompozycja farmaceutyczna, izolowana sekwencja kwasu nukleinowego, rekombinowany plazmid i komórka gospodarza oraz sposób wytwarzania humanizowanego przeciwciała i sposób wspomagania diagnostyki alergii
US7399837B2 (en) 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5693323A (en) 1994-12-23 1997-12-02 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
HUP0200958A3 (en) 1999-04-23 2004-11-29 Pharmexa As Method for down-regulating il5 activity
EP2027157B1 (en) 2006-05-25 2014-08-06 Glaxo Group Limited Modified humanised anti-interleukin-18 antibodies
BRPI0910854A2 (pt) 2008-03-28 2015-10-06 Glaxosmithkline Llc métodos de tratamento
EP2337801A4 (en) 2008-10-06 2012-07-25 Minerva Biotechnologies Corp MUC1 ANTIBODIES *
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN103429606A (zh) 2010-10-01 2013-12-04 现代治疗公司 设计核酸及其使用方法
EP2654790B1 (en) * 2010-12-22 2019-02-06 Teva Pharmaceuticals Australia Pty Ltd Modified antibody with improved half-life
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RS62993B1 (sr) 2011-10-03 2022-03-31 Modernatx Inc Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
SG10201604896TA (en) 2011-12-16 2016-08-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
JP2015513913A (ja) 2012-04-02 2015-05-18 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ポリヌクレオチド
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
JP6502856B2 (ja) 2012-12-26 2019-04-17 オンコシナジー インコーポレイテッド 抗インテグリンβ１抗体組成物及びその使用方法
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
CA2926218A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
TW201613615A (en) * 2014-06-30 2016-04-16 Academia Sinica Antagonists for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B for cancer therapy
US11746159B2 (en) 2015-02-10 2023-09-05 Minerva Biotechnologies Corporation Humanized anti-MUC1* antibodies
CA2996088A1 (en) 2015-08-24 2017-03-02 Glaxosmithkline Intellectual Property (No. 2) Limited Biopharmaceutical compositions
EP3634467A4 (en) 2017-06-06 2021-07-28 GlaxoSmithKline LLC BIOPHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR PEDIATRIC PATIENTS
WO2019062831A1 (zh) 2017-09-29 2019-04-04 江苏恒瑞医药股份有限公司 Il-5抗体、其抗原结合片段及医药用途
CN109942706A (zh) * 2017-12-21 2019-06-28 三生国健药业（上海）股份有限公司 结合人il-5的单克隆抗体、其制备方法和用途
CN113366016B (zh) * 2018-12-12 2022-12-16 上海开拓者生物医药有限公司 抗人白细胞介素5(il-5)单克隆抗体及其应用
WO2020200099A1 (zh) 2019-03-29 2020-10-08 江苏恒瑞医药股份有限公司 包含抗il-5抗体的药物组合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DE68911653T2 (de) * 1988-11-03 1994-04-07 Schering Corp Antagonist für Interleukin-5 zur Verhütung oder Verminderung von Eosinophilie.
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1992008474A2 (en) * 1990-11-20 1992-05-29 The National Heart & Lung Institute Treatment of lung diseases
SK280610B6 (sk) * 1992-02-06 2000-05-16 Schering Corporation Monoklonálna a humanizovaná monoklonálna protilátk
JPH07502901A (ja) * 1992-02-19 1995-03-30 シェリング・コーポレーション ヒトインターロイキン−４に対するヒト化モノクローナル抗体のクローニング及び発現
GB9412230D0 (en) * 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies

Also Published As

Publication number Publication date
JPH10501697A (ja) 1998-02-17
GB9412230D0 (en) 1994-08-10
IL114179A0 (en) 1995-10-31
SK282625B6 (sk) 2002-10-08
US6734286B2 (en) 2004-05-11
US6316227B1 (en) 2001-11-13
CA2192543A1 (en) 1995-12-28
ATE264389T1 (de) 2004-04-15
FI965032A0 (fi) 1996-12-16
NO964808D0 (no) 1996-11-13
DE69532889T2 (de) 2005-03-10
CZ292295B6 (cs) 2003-08-13
WO1995035375A1 (en) 1995-12-28
IL114179A (en) 2001-08-26
FI965032A (fi) 1996-12-16
DE69532889D1 (de) 2004-05-19
US20020042089A1 (en) 2002-04-11
AU2680395A (en) 1996-01-15
CZ371296A3 (cs) 1998-05-13
HU9603183D0 (en) 1997-01-28
JP3973682B2 (ja) 2007-09-12
US5998586A (en) 1999-12-07
EP0765392A1 (en) 1997-04-02
AU694783B2 (en) 1998-07-30
ES2218546T3 (es) 2004-11-16
EP0765392B1 (en) 2004-04-14
CA2192543C (en) 2008-07-29
NZ287927A (en) 1998-07-28
SK160096A3 (en) 1997-06-04
HU221641B1 (hu) 2002-12-28
HUT76672A (en) 1997-10-28
NO964808L (no) 1997-02-17

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