ZA9545B - Bicyclic fibrinogen antagonists - Google Patents

Bicyclic fibrinogen antagonists

Info

Publication number
ZA9545B
ZA9545B ZA9545A ZA9545A ZA9545B ZA 9545 B ZA9545 B ZA 9545B ZA 9545 A ZA9545 A ZA 9545A ZA 9545 A ZA9545 A ZA 9545A ZA 9545 B ZA9545 B ZA 9545B
Authority
ZA
South Africa
Prior art keywords
fibrinogen antagonists
bicyclic fibrinogen
bicyclic
antagonists
fibrinogen
Prior art date
Application number
ZA9545A
Other languages
English (en)
Inventor
William Edward Bondinell
James Francis Callahan
William Francis Huffman
Richard Mcculloch Keenan
Thomas Wen-Fu Ku
Kenneth Allen Newlander
James Martin Samanen
Irene Nijole Uzinskas
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA9545B publication Critical patent/ZA9545B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9545A 1994-01-07 1995-01-05 Bicyclic fibrinogen antagonists ZA9545B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17901194A 1994-01-07 1994-01-07

Publications (1)

Publication Number Publication Date
ZA9545B true ZA9545B (en) 1996-01-23

Family

ID=22654859

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9545A ZA9545B (en) 1994-01-07 1995-01-05 Bicyclic fibrinogen antagonists

Country Status (27)

Country Link
US (1) US6117866A (cs)
EP (1) EP0738150B1 (cs)
JP (1) JPH09508620A (cs)
KR (1) KR100388772B1 (cs)
CN (1) CN1117569C (cs)
AP (1) AP542A (cs)
AT (1) ATE238993T1 (cs)
AU (1) AU699186B2 (cs)
BG (2) BG62844B1 (cs)
BR (1) BR9506499A (cs)
CZ (1) CZ292323B6 (cs)
DE (1) DE69530571T2 (cs)
DK (1) DK0738150T3 (cs)
ES (1) ES2197914T3 (cs)
HK (1) HK1014668A1 (cs)
HU (1) HUT76282A (cs)
IL (1) IL112243A (cs)
MA (1) MA23420A1 (cs)
NO (1) NO962859L (cs)
NZ (1) NZ279394A (cs)
OA (1) OA10368A (cs)
PT (1) PT738150E (cs)
SG (1) SG64884A1 (cs)
SK (1) SK86996A3 (cs)
TW (1) TW420682B (cs)
WO (1) WO1995018619A1 (cs)
ZA (1) ZA9545B (cs)

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JPH10504807A (ja) * 1994-06-29 1998-05-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗剤
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CN1102391C (zh) 1996-09-03 2003-03-05 史密丝克莱恩比彻姆公司 结晶状的药用产物
EP0964928A1 (en) * 1996-12-27 1999-12-22 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase
KR20010015866A (ko) * 1997-12-09 2001-02-26 모치즈키 노부히코 톨루엔 유도체의 제조방법
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
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CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
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WO2003088897A2 (en) 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
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AU2003301346A1 (en) * 2002-10-17 2004-05-04 The Trustees Of The University Of Pennsylvania Method of treating neurological diseases and disorders
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625334B9 (en) 2003-05-21 2012-07-25 Alexza Pharmaceuticals, Inc. Percussively ignited self-contained heating unit
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US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
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EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
WO2010093706A2 (en) 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination
JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーDebiopharm International Sa (e)−n−メチル−n−((3−メチルベンゾフラン−2−イル)メチル)−3−(7−オキソ−5,6,7,8−テトラヒドロ−1,8−ナフチリジン−3−イル)アクリルアミドのプロドラッグ誘導体
US10751351B2 (en) 2016-02-26 2020-08-25 Debiopharm International S.A. Medicament for treatment of diabetic foot infections

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Also Published As

Publication number Publication date
WO1995018619A1 (en) 1995-07-13
CN1117569C (zh) 2003-08-13
AP9500710A0 (en) 1995-01-31
KR100388772B1 (ko) 2003-11-20
IL112243A0 (en) 1995-03-30
DE69530571D1 (de) 2003-06-05
HK1014668A1 (en) 1999-09-30
PT738150E (pt) 2003-08-29
CZ292323B6 (cs) 2003-09-17
US6117866A (en) 2000-09-12
SG64884A1 (en) 1999-05-25
EP0738150A4 (en) 1997-03-19
BG100698A (bg) 1997-02-28
NZ279394A (en) 1998-05-27
NO962859L (no) 1996-09-05
AU1600195A (en) 1995-08-01
TW420682B (en) 2001-02-01
NO962859D0 (no) 1996-07-05
ATE238993T1 (de) 2003-05-15
EP0738150A1 (en) 1996-10-23
BG102863A (en) 1999-05-31
CN1143323A (zh) 1997-02-19
BG62844B1 (bg) 2000-09-29
HU9601849D0 (en) 1996-09-30
AU699186B2 (en) 1998-11-26
CZ198196A3 (en) 1997-06-11
EP0738150B1 (en) 2003-05-02
IL112243A (en) 1999-12-31
OA10368A (en) 2001-11-15
ES2197914T3 (es) 2004-01-16
DK0738150T3 (da) 2003-08-25
MA23420A1 (fr) 1995-10-01
HUT76282A (en) 1997-07-28
JPH09508620A (ja) 1997-09-02
WO1995018619A9 (en) 2004-10-21
BR9506499A (pt) 1997-09-09
DE69530571T2 (de) 2004-03-04
SK86996A3 (en) 1997-02-05
AP542A (en) 1996-10-01

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