ZA9510263B - New highly selective process for the preparation of enantiomerically pure phenylsubstituted 1,4-dihydropyridine 3,5-dicarboxylic acid derivatives - Google Patents

New highly selective process for the preparation of enantiomerically pure phenylsubstituted 1,4-dihydropyridine 3,5-dicarboxylic acid derivatives

Info

Publication number
ZA9510263B
ZA9510263B ZA9510263A ZA9510263A ZA9510263B ZA 9510263 B ZA9510263 B ZA 9510263B ZA 9510263 A ZA9510263 A ZA 9510263A ZA 9510263 A ZA9510263 A ZA 9510263A ZA 9510263 B ZA9510263 B ZA 9510263B
Authority
ZA
South Africa
Prior art keywords
formula
enantiomerically pure
alkyl
preparation
esters
Prior art date
Application number
ZA9510263A
Other languages
English (en)
Inventor
Joachim Mittendorf
Peter Fey
Bodo Junge
Johannes Kaulen
Kai Van Laak
Heinrich Meier
Rudolf Schohe-Loop
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA9510263B publication Critical patent/ZA9510263B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA9510263A 1994-12-05 1995-12-04 New highly selective process for the preparation of enantiomerically pure phenylsubstituted 1,4-dihydropyridine 3,5-dicarboxylic acid derivatives ZA9510263B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443168A DE4443168A1 (de) 1994-12-05 1994-12-05 Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten

Publications (1)

Publication Number Publication Date
ZA9510263B true ZA9510263B (en) 1996-06-12

Family

ID=6534908

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9510263A ZA9510263B (en) 1994-12-05 1995-12-04 New highly selective process for the preparation of enantiomerically pure phenylsubstituted 1,4-dihydropyridine 3,5-dicarboxylic acid derivatives

Country Status (27)

Country Link
US (4) US5700948A (fr)
EP (2) EP0716081B1 (fr)
JP (1) JP3891500B2 (fr)
KR (1) KR100396011B1 (fr)
CN (5) CN1079793C (fr)
AT (1) ATE322482T1 (fr)
AU (1) AU702274B2 (fr)
CA (1) CA2164276C (fr)
CZ (1) CZ296438B6 (fr)
DE (2) DE4443168A1 (fr)
DK (1) DK0716081T3 (fr)
ES (1) ES2262138T3 (fr)
FI (1) FI115908B (fr)
HU (1) HU214683B (fr)
IL (1) IL116225A (fr)
MX (1) MX9504954A (fr)
MY (1) MY112938A (fr)
NO (1) NO312832B1 (fr)
NZ (1) NZ280578A (fr)
PL (1) PL183604B1 (fr)
PT (1) PT716081E (fr)
RU (1) RU2155752C2 (fr)
SG (1) SG73352A1 (fr)
SI (1) SI0716081T1 (fr)
SK (1) SK282428B6 (fr)
TW (1) TW310324B (fr)
ZA (1) ZA9510263B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533154B1 (ko) 2022-09-22 2023-05-17 임태형 안전계단 난간대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2911029C2 (de) * 1979-03-21 1985-03-14 Kombi-Lift Montage- Und Handelsgesellschaft Mbh, 5650 Solingen Vorrichtung zum Haltern der Führungsrollen für die Lastseile eines Fassadenseilaufzuges in einem oben am Gebäude fest angeordneten Gehäuse
GR850872B (fr) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US4539302A (en) * 1984-04-30 1985-09-03 E. I. Du Pont De Nemours And Company Recovery of zerovalent nickel complexes
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Also Published As

Publication number Publication date
CA2164276C (fr) 2007-04-10
CZ320595A3 (en) 1996-06-12
NO954885D0 (no) 1995-12-01
MX9504954A (es) 1997-01-31
ATE322482T1 (de) 2006-04-15
JP3891500B2 (ja) 2007-03-14
PL183604B1 (pl) 2002-06-28
CN1094926C (zh) 2002-11-27
CN1105102C (zh) 2003-04-09
CN1079793C (zh) 2002-02-27
HU214683B (hu) 1998-04-28
NO954885L (no) 1996-06-06
CZ296438B6 (cs) 2006-03-15
USRE36607E (en) 2000-03-07
CN1131664A (zh) 1996-09-25
JPH08225529A (ja) 1996-09-03
CN1094486C (zh) 2002-11-20
RU2155752C2 (ru) 2000-09-10
HUT74292A (en) 1996-11-28
CA2164276A1 (fr) 1996-06-06
NO312832B1 (no) 2002-07-08
CN1269357A (zh) 2000-10-11
US5849924A (en) 1998-12-15
HU9503438D0 (en) 1996-01-29
CN1269362A (zh) 2000-10-11
IL116225A0 (en) 1996-03-31
AU3915095A (en) 1996-06-13
EP1443043A2 (fr) 2004-08-04
SI0716081T1 (sl) 2006-06-30
FI955825A (fi) 1996-06-06
DK0716081T3 (da) 2006-08-07
KR960022463A (ko) 1996-07-18
SG73352A1 (en) 2000-06-20
KR100396011B1 (ko) 2003-11-10
FI115908B (fi) 2005-08-15
DE4443168A1 (de) 1996-06-13
ES2262138T3 (es) 2006-11-16
FI955825A0 (fi) 1995-12-04
EP0716081B1 (fr) 2006-04-05
AU702274B2 (en) 1999-02-18
MY112938A (en) 2001-10-31
EP0716081A1 (fr) 1996-06-12
SK152695A3 (en) 1996-06-05
IL116225A (en) 2000-06-29
CN1269359A (zh) 2000-10-11
US5700948A (en) 1997-12-23
CN1269358A (zh) 2000-10-11
SK282428B6 (sk) 2002-01-07
NZ280578A (en) 1996-10-28
EP1443043A3 (fr) 2005-02-02
PL311539A1 (en) 1996-06-10
PT716081E (pt) 2006-08-31
US5910593A (en) 1999-06-08
CN1216054C (zh) 2005-08-24
DE59511043D1 (de) 2006-05-18
TW310324B (fr) 1997-07-11

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