ZA948772B - Antithrombotic amidinophenylalanine and amidinopyridy-lalanine derivatives - Google Patents
Antithrombotic amidinophenylalanine and amidinopyridy-lalanine derivativesInfo
- Publication number
- ZA948772B ZA948772B ZA948772A ZA948772A ZA948772B ZA 948772 B ZA948772 B ZA 948772B ZA 948772 A ZA948772 A ZA 948772A ZA 948772 A ZA948772 A ZA 948772A ZA 948772 B ZA948772 B ZA 948772B
- Authority
- ZA
- South Africa
- Prior art keywords
- conr5r6
- pct
- optionally substituted
- alkyl
- nr5r6
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Treating Waste Gases (AREA)
- Polyurethanes Or Polyureas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939322976A GB9322976D0 (en) | 1993-11-08 | 1993-11-08 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA948772B true ZA948772B (en) | 1996-05-07 |
Family
ID=10744811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA948772A ZA948772B (en) | 1993-11-08 | 1994-11-07 | Antithrombotic amidinophenylalanine and amidinopyridy-lalanine derivatives |
Country Status (25)
Country | Link |
---|---|
US (2) | US5750520A (de) |
EP (1) | EP0728132B1 (de) |
JP (1) | JP2739776B2 (de) |
KR (1) | KR960705807A (de) |
CN (1) | CN1134148A (de) |
AT (1) | ATE155464T1 (de) |
AU (1) | AU680565B2 (de) |
CA (1) | CA2176037C (de) |
CO (1) | CO4290420A1 (de) |
CZ (1) | CZ282359B6 (de) |
DE (1) | DE69404325T2 (de) |
DK (1) | DK0728132T3 (de) |
ES (1) | ES2105868T3 (de) |
FI (1) | FI112481B (de) |
GB (1) | GB9322976D0 (de) |
GR (1) | GR3024228T3 (de) |
HU (1) | HUT76268A (de) |
IL (1) | IL111478A0 (de) |
NO (1) | NO961841L (de) |
NZ (1) | NZ275798A (de) |
PE (1) | PE22795A1 (de) |
PL (1) | PL314237A1 (de) |
SG (1) | SG52218A1 (de) |
WO (1) | WO1995013274A1 (de) |
ZA (1) | ZA948772B (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9522495D0 (en) * | 1995-11-02 | 1996-01-03 | Pfizer Ltd | Therapeutic agents |
US7109326B2 (en) | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
AU8875798A (en) * | 1997-08-29 | 1999-03-22 | Proteus Molecular Design Ltd | Meta-benzamidine derivatives as serin protease inhibitors |
US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
EP1023269A4 (de) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | Beta3-adrenoreceptor-agonisten, agonist-zubereitungen und verfahren zu ihrer verwendung |
DE69912379T2 (de) | 1998-08-14 | 2004-05-06 | Pfizer Inc. | Antithrombosemittel |
US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
SI20743A (sl) * | 2000-12-22 | 2002-06-30 | Univerza V Ljubljani, | Novi trombinski inhibitorji |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
SI21137A (sl) * | 2002-01-24 | 2003-08-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Derivati azafenilalanina |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
CN1703395A (zh) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
EP2332920A3 (de) * | 2003-06-17 | 2011-12-21 | Arena Pharmaceuticals, Inc. | Verfahren zur Herstellung von 3-Benzazepinen |
PL2332921T3 (pl) * | 2003-06-17 | 2016-08-31 | Arena Pharm Inc | Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
AU2004263508A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7459472B2 (en) * | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US20070275949A1 (en) * | 2003-10-22 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases |
US20080009478A1 (en) * | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
NZ555981A (en) | 2004-12-21 | 2011-01-28 | Arena Pharm Inc | Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
NZ555482A (en) | 2004-12-23 | 2011-01-28 | Arena Pharm Inc | Compositions comprising a 5HT2C receptor modulator and 2-methylamphetamine and methods of use |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
GB0523539D0 (en) * | 2005-11-18 | 2005-12-28 | Lek Tovarna Farmacevtskih | New use of organic compounds |
EP2471779A1 (de) | 2006-04-03 | 2012-07-04 | Arena Pharmaceuticals, Inc. | Verfahren zur Trennung einer Mischung von (R)- und (S)-8-Chlor-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin |
TWI389899B (zh) * | 2006-08-08 | 2013-03-21 | Msd Oss Bv | 具口服活性之凝血酶抑制劑 |
ES2522587T3 (es) * | 2006-12-05 | 2014-11-17 | Arena Pharmaceuticals, Inc. | Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma |
CN102015675B (zh) * | 2008-02-21 | 2014-07-02 | 赛诺菲 | 作为凝血因子Xa和凝血酶的抑制剂的氯噻吩-酰胺 |
WO2009103439A1 (en) * | 2008-02-21 | 2009-08-27 | Sanofi-Aventis | Chlorothiophene-isoxazoles as inhibitors of coagulation factors xa and thrombin |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
AR080374A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
KR20180118801A (ko) | 2010-09-01 | 2018-10-31 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태 |
CA2808909A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
WO2012030957A2 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
CN103347523A (zh) | 2010-09-01 | 2013-10-09 | 艾尼纳制药公司 | 向具有肾损伤的个体给药氯卡色林 |
BR112015007779A2 (pt) | 2012-10-09 | 2017-07-04 | Arena Pharm Inc | célula de fluxo de permeabilidade e sistema de condutância hidráulica |
US10968172B2 (en) | 2017-05-15 | 2021-04-06 | Mitobridge, Inc. | USP30 inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8868991A (en) * | 1990-11-15 | 1992-06-11 | Pentapharm Ag | Meta-substituted phenyl alanine derivatives |
-
1993
- 1993-11-08 GB GB939322976A patent/GB9322976D0/en active Pending
-
1994
- 1994-10-24 NZ NZ275798A patent/NZ275798A/en unknown
- 1994-10-24 HU HU9601229A patent/HUT76268A/hu unknown
- 1994-10-24 PL PL94314237A patent/PL314237A1/xx unknown
- 1994-10-24 US US08/628,642 patent/US5750520A/en not_active Expired - Fee Related
- 1994-10-24 EP EP95900087A patent/EP0728132B1/de not_active Expired - Lifetime
- 1994-10-24 JP JP7513554A patent/JP2739776B2/ja not_active Expired - Fee Related
- 1994-10-24 DK DK95900087.8T patent/DK0728132T3/da active
- 1994-10-24 AT AT95900087T patent/ATE155464T1/de not_active IP Right Cessation
- 1994-10-24 CZ CZ961322A patent/CZ282359B6/cs unknown
- 1994-10-24 ES ES95900087T patent/ES2105868T3/es not_active Expired - Lifetime
- 1994-10-24 CN CN94194003A patent/CN1134148A/zh active Pending
- 1994-10-24 CA CA002176037A patent/CA2176037C/en not_active Expired - Fee Related
- 1994-10-24 WO PCT/EP1994/003509 patent/WO1995013274A1/en active IP Right Grant
- 1994-10-24 SG SG1996000579A patent/SG52218A1/en unknown
- 1994-10-24 KR KR1019960702386A patent/KR960705807A/ko not_active Application Discontinuation
- 1994-10-24 AU AU81049/94A patent/AU680565B2/en not_active Expired - Fee Related
- 1994-10-24 DE DE69404325T patent/DE69404325T2/de not_active Expired - Fee Related
- 1994-10-31 IL IL11147894A patent/IL111478A0/xx unknown
- 1994-11-02 PE PE1994253992A patent/PE22795A1/es not_active Application Discontinuation
- 1994-11-04 CO CO94050730A patent/CO4290420A1/es unknown
- 1994-11-07 ZA ZA948772A patent/ZA948772B/xx unknown
-
1996
- 1996-05-07 NO NO961841A patent/NO961841L/no unknown
- 1996-05-07 FI FI961939A patent/FI112481B/fi active
-
1997
- 1997-07-23 GR GR970401874T patent/GR3024228T3/el unknown
- 1997-07-30 US US08/902,917 patent/US5861393A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH09500391A (ja) | 1997-01-14 |
WO1995013274A1 (en) | 1995-05-18 |
FI961939A0 (fi) | 1996-05-07 |
NZ275798A (en) | 1997-09-22 |
CO4290420A1 (es) | 1996-04-17 |
KR960705807A (ko) | 1996-11-08 |
JP2739776B2 (ja) | 1998-04-15 |
EP0728132B1 (de) | 1997-07-16 |
GR3024228T3 (en) | 1997-10-31 |
ATE155464T1 (de) | 1997-08-15 |
GB9322976D0 (en) | 1994-01-05 |
SG52218A1 (en) | 1998-09-28 |
FI961939A (fi) | 1996-05-07 |
AU8104994A (en) | 1995-05-29 |
CA2176037C (en) | 1999-07-13 |
EP0728132A1 (de) | 1996-08-28 |
CN1134148A (zh) | 1996-10-23 |
HUT76268A (en) | 1997-07-28 |
US5750520A (en) | 1998-05-12 |
US5861393A (en) | 1999-01-19 |
PL314237A1 (en) | 1996-09-02 |
PE22795A1 (es) | 1995-08-15 |
CA2176037A1 (en) | 1995-05-18 |
FI112481B (fi) | 2003-12-15 |
IL111478A0 (en) | 1994-12-29 |
CZ282359B6 (cs) | 1997-07-16 |
ES2105868T3 (es) | 1997-10-16 |
HU9601229D0 (en) | 1996-07-29 |
CZ132296A3 (en) | 1996-08-14 |
NO961841D0 (no) | 1996-05-07 |
AU680565B2 (en) | 1997-07-31 |
DK0728132T3 (da) | 1997-09-01 |
DE69404325D1 (de) | 1997-08-21 |
NO961841L (no) | 1996-05-07 |
DE69404325T2 (de) | 1997-10-30 |
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