ATE155464T1 - Antithrombotische amidinophenylalanin- und amidinopyridylalanin-derivate - Google Patents

Antithrombotische amidinophenylalanin- und amidinopyridylalanin-derivate

Info

Publication number
ATE155464T1
ATE155464T1 AT95900087T AT95900087T ATE155464T1 AT E155464 T1 ATE155464 T1 AT E155464T1 AT 95900087 T AT95900087 T AT 95900087T AT 95900087 T AT95900087 T AT 95900087T AT E155464 T1 ATE155464 T1 AT E155464T1
Authority
AT
Austria
Prior art keywords
conr5r6
pct
optionally substituted
alkyl
nr5r6
Prior art date
Application number
AT95900087T
Other languages
English (en)
Inventor
John Christopher Danilewicz
David Ellis
Ryszard Jurek Kobylecki
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Application granted granted Critical
Publication of ATE155464T1 publication Critical patent/ATE155464T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
AT95900087T 1993-11-08 1994-10-24 Antithrombotische amidinophenylalanin- und amidinopyridylalanin-derivate ATE155464T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939322976A GB9322976D0 (en) 1993-11-08 1993-11-08 Therapeutic agents

Publications (1)

Publication Number Publication Date
ATE155464T1 true ATE155464T1 (de) 1997-08-15

Family

ID=10744811

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95900087T ATE155464T1 (de) 1993-11-08 1994-10-24 Antithrombotische amidinophenylalanin- und amidinopyridylalanin-derivate

Country Status (25)

Country Link
US (2) US5750520A (de)
EP (1) EP0728132B1 (de)
JP (1) JP2739776B2 (de)
KR (1) KR960705807A (de)
CN (1) CN1134148A (de)
AT (1) ATE155464T1 (de)
AU (1) AU680565B2 (de)
CA (1) CA2176037C (de)
CO (1) CO4290420A1 (de)
CZ (1) CZ282359B6 (de)
DE (1) DE69404325T2 (de)
DK (1) DK0728132T3 (de)
ES (1) ES2105868T3 (de)
FI (1) FI112481B (de)
GB (1) GB9322976D0 (de)
GR (1) GR3024228T3 (de)
HU (1) HUT76268A (de)
IL (1) IL111478A0 (de)
NO (1) NO961841D0 (de)
NZ (1) NZ275798A (de)
PE (1) PE22795A1 (de)
PL (1) PL314237A1 (de)
SG (1) SG52218A1 (de)
WO (1) WO1995013274A1 (de)
ZA (1) ZA948772B (de)

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GB9522495D0 (en) * 1995-11-02 1996-01-03 Pfizer Ltd Therapeutic agents
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
WO1999011658A1 (en) * 1997-08-29 1999-03-11 Proteus Molecular Design Ltd. Meta-benzamidine derivatives as serin protease inhibitors
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
JP2001518468A (ja) * 1997-09-30 2001-10-16 モレキュラー デザインズ インターナショナル，インコーポレイテッド β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法
ATE253076T1 (de) 1998-08-14 2003-11-15 Pfizer Antithrombosemittel
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
SI20743A (sl) * 2000-12-22 2002-06-30 Univerza V Ljubljani, Novi trombinski inhibitorji
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
SI21137A (sl) * 2002-01-24 2003-08-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Derivati azafenilalanina
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US7122580B2 (en) * 2002-08-09 2006-10-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
PL2332921T3 (pl) * 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
EP2332920A3 (de) * 2003-06-17 2011-12-21 Arena Pharmaceuticals, Inc. Verfahren zur Herstellung von 3-Benzazepinen
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
JP2007501844A (ja) * 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
CN101084193B (zh) 2004-12-21 2011-12-07 艾尼纳制药公司 (r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓盐酸盐的晶型
SG158168A1 (en) * 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0523539D0 (en) * 2005-11-18 2005-12-28 Lek Tovarna Farmacevtskih New use of organic compounds
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
JP5422570B2 (ja) * 2008-02-21 2014-02-19 サノフイ 凝固第Ｘａ因子及びトロンビンの阻害剤としてのクロロチオフェン−アミド類
EP2280964B1 (de) * 2008-02-21 2012-08-29 Sanofi Chlorthiophenisoxazole als inhibitoren von koagulationsfaktor xa und thrombin
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
JP6272695B2 (ja) 2010-09-01 2018-01-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形
EP2611449A1 (de) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Verabreichung von lorcaserin an personen mit nierenerkrankungen
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
WO2012030938A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
UY34436A (es) 2012-10-09 2014-07-31 Arena Pharm Inc Metodo de control del peso
US10968172B2 (en) 2017-05-15 2021-04-06 Mitobridge, Inc. USP30 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073776A1 (en) * 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives

Also Published As

Publication number Publication date
JP2739776B2 (ja) 1998-04-15
GB9322976D0 (en) 1994-01-05
HUT76268A (en) 1997-07-28
NO961841L (no) 1996-05-07
WO1995013274A1 (en) 1995-05-18
GR3024228T3 (en) 1997-10-31
SG52218A1 (en) 1998-09-28
ZA948772B (en) 1996-05-07
KR960705807A (ko) 1996-11-08
AU8104994A (en) 1995-05-29
CZ282359B6 (cs) 1997-07-16
DE69404325T2 (de) 1997-10-30
EP0728132A1 (de) 1996-08-28
ES2105868T3 (es) 1997-10-16
NO961841D0 (no) 1996-05-07
EP0728132B1 (de) 1997-07-16
PE22795A1 (es) 1995-08-15
CO4290420A1 (es) 1996-04-17
US5750520A (en) 1998-05-12
JPH09500391A (ja) 1997-01-14
DK0728132T3 (da) 1997-09-01
PL314237A1 (en) 1996-09-02
FI961939A (fi) 1996-05-07
CA2176037C (en) 1999-07-13
IL111478A0 (en) 1994-12-29
DE69404325D1 (de) 1997-08-21
US5861393A (en) 1999-01-19
AU680565B2 (en) 1997-07-31
FI112481B (fi) 2003-12-15
HU9601229D0 (en) 1996-07-29
FI961939A0 (fi) 1996-05-07
NZ275798A (en) 1997-09-22
CZ132296A3 (en) 1996-08-14
CN1134148A (zh) 1996-10-23
CA2176037A1 (en) 1995-05-18

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee