FI961939A - Antitromboottiset amidinofenyylialaniini- ja amidinopyridyylialaniinijohdannaiset - Google Patents

Antitromboottiset amidinofenyylialaniini- ja amidinopyridyylialaniinijohdannaiset Download PDF

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Publication number
FI961939A
FI961939A FI961939A FI961939A FI961939A FI 961939 A FI961939 A FI 961939A FI 961939 A FI961939 A FI 961939A FI 961939 A FI961939 A FI 961939A FI 961939 A FI961939 A FI 961939A
Authority
FI
Finland
Prior art keywords
conr5r6
pct
optionally substituted
alkyl
nr5r6
Prior art date
Application number
FI961939A
Other languages
English (en)
Swedish (sv)
Other versions
FI961939A0 (fi
FI112481B (fi
Inventor
John Christopher Danilewicz
David Ellis
Ryszard Jurek Kobylecki
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of FI961939A0 publication Critical patent/FI961939A0/fi
Publication of FI961939A publication Critical patent/FI961939A/fi
Application granted granted Critical
Publication of FI112481B publication Critical patent/FI112481B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI961939A 1993-11-08 1996-05-07 Menetelmä antitromboottisten amidinofenyylialaniini- ja amidinopyridyylialaniinijohdannaisten valmistamiseksi FI112481B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9322976 1993-11-08
GB939322976A GB9322976D0 (en) 1993-11-08 1993-11-08 Therapeutic agents
PCT/EP1994/003509 WO1995013274A1 (en) 1993-11-08 1994-10-24 Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives
EP9403509 1994-10-24

Publications (3)

Publication Number Publication Date
FI961939A0 FI961939A0 (fi) 1996-05-07
FI961939A true FI961939A (fi) 1996-05-07
FI112481B FI112481B (fi) 2003-12-15

Family

ID=10744811

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961939A FI112481B (fi) 1993-11-08 1996-05-07 Menetelmä antitromboottisten amidinofenyylialaniini- ja amidinopyridyylialaniinijohdannaisten valmistamiseksi

Country Status (25)

Country Link
US (2) US5750520A (fi)
EP (1) EP0728132B1 (fi)
JP (1) JP2739776B2 (fi)
KR (1) KR960705807A (fi)
CN (1) CN1134148A (fi)
AT (1) ATE155464T1 (fi)
AU (1) AU680565B2 (fi)
CA (1) CA2176037C (fi)
CO (1) CO4290420A1 (fi)
CZ (1) CZ282359B6 (fi)
DE (1) DE69404325T2 (fi)
DK (1) DK0728132T3 (fi)
ES (1) ES2105868T3 (fi)
FI (1) FI112481B (fi)
GB (1) GB9322976D0 (fi)
GR (1) GR3024228T3 (fi)
HU (1) HUT76268A (fi)
IL (1) IL111478A0 (fi)
NO (1) NO961841L (fi)
NZ (1) NZ275798A (fi)
PE (1) PE22795A1 (fi)
PL (1) PL314237A1 (fi)
SG (1) SG52218A1 (fi)
WO (1) WO1995013274A1 (fi)
ZA (1) ZA948772B (fi)

Families Citing this family (40)

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GB9522495D0 (en) * 1995-11-02 1996-01-03 Pfizer Ltd Therapeutic agents
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
US6262069B1 (en) * 1997-08-29 2001-07-17 Protherics Molecular Design Limited 1-amino-7-isoquinoline derivatives as serine protease inhibitors
EP1023269A4 (en) * 1997-09-30 2001-06-27 Molecular Design Int BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE
ATE253076T1 (de) 1998-08-14 2003-11-15 Pfizer Antithrombosemittel
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
SI20743A (sl) * 2000-12-22 2002-06-30 Univerza V Ljubljani, Novi trombinski inhibitorji
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
SI21137A (sl) * 2002-01-24 2003-08-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Derivati azafenilalanina
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2004014844A2 (en) * 2002-08-09 2004-02-19 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN1805939B (zh) 2003-06-17 2010-10-13 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
HUE028976T2 (en) 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
JP2007501844A (ja) * 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
US7501538B2 (en) * 2003-08-08 2009-03-10 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
DK1838677T3 (da) 2004-12-21 2010-01-11 Arena Pharm Inc Krystallinske former af (R)-8-chlor-1.methyl-2,3,4,5-tetrahydro-1H-3-benzazepinhydrochlorid
SI1833473T1 (sl) 2004-12-23 2010-01-29 Arena Pharm Inc Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0523539D0 (en) * 2005-11-18 2005-12-28 Lek Tovarna Farmacevtskih New use of organic compounds
JP5199997B2 (ja) * 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
WO2009103439A1 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Chlorothiophene-isoxazoles as inhibitors of coagulation factors xa and thrombin
AU2009217075B2 (en) * 2008-02-21 2013-05-16 Sanofi-Aventis Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management
US10968172B2 (en) 2017-05-15 2021-04-06 Mitobridge, Inc. USP30 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073776A1 (en) * 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives

Also Published As

Publication number Publication date
HU9601229D0 (en) 1996-07-29
CZ132296A3 (en) 1996-08-14
CA2176037A1 (en) 1995-05-18
CN1134148A (zh) 1996-10-23
JP2739776B2 (ja) 1998-04-15
PL314237A1 (en) 1996-09-02
WO1995013274A1 (en) 1995-05-18
ATE155464T1 (de) 1997-08-15
KR960705807A (ko) 1996-11-08
FI961939A0 (fi) 1996-05-07
GR3024228T3 (en) 1997-10-31
CZ282359B6 (cs) 1997-07-16
SG52218A1 (en) 1998-09-28
PE22795A1 (es) 1995-08-15
AU680565B2 (en) 1997-07-31
DK0728132T3 (da) 1997-09-01
FI112481B (fi) 2003-12-15
NO961841D0 (no) 1996-05-07
ES2105868T3 (es) 1997-10-16
AU8104994A (en) 1995-05-29
IL111478A0 (en) 1994-12-29
EP0728132A1 (en) 1996-08-28
NZ275798A (en) 1997-09-22
US5750520A (en) 1998-05-12
CA2176037C (en) 1999-07-13
DE69404325D1 (de) 1997-08-21
NO961841L (no) 1996-05-07
EP0728132B1 (en) 1997-07-16
JPH09500391A (ja) 1997-01-14
CO4290420A1 (es) 1996-04-17
US5861393A (en) 1999-01-19
ZA948772B (en) 1996-05-07
HUT76268A (en) 1997-07-28
GB9322976D0 (en) 1994-01-05
DE69404325T2 (de) 1997-10-30

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