ZA938478B - Vitamin D3 analogs - Google Patents

Vitamin D3 analogs

Info

Publication number
ZA938478B
ZA938478B ZA938478A ZA938478A ZA938478B ZA 938478 B ZA938478 B ZA 938478B ZA 938478 A ZA938478 A ZA 938478A ZA 938478 A ZA938478 A ZA 938478A ZA 938478 B ZA938478 B ZA 938478B
Authority
ZA
South Africa
Prior art keywords
analogs
vitamin
hydrogen
diseases
acyl
Prior art date
Application number
ZA938478A
Other languages
English (en)
Inventor
Thomas I Doran
Masami Okabe
Milan Radoje Uskokovic
John Arthur Mclane
Michelangelo Scalone
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA938478B publication Critical patent/ZA938478B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA938478A 1992-11-20 1993-11-12 Vitamin D3 analogs ZA938478B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97913392A 1992-11-20 1992-11-20

Publications (1)

Publication Number Publication Date
ZA938478B true ZA938478B (en) 1994-05-20

Family

ID=25526724

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA938478A ZA938478B (en) 1992-11-20 1993-11-12 Vitamin D3 analogs

Country Status (25)

Country Link
US (3) US5342833A (enExample)
EP (1) EP0599114B1 (enExample)
JP (2) JP2502931B2 (enExample)
KR (1) KR940011443A (enExample)
CN (1) CN1051762C (enExample)
AT (1) ATE147728T1 (enExample)
AU (1) AU669222B2 (enExample)
BR (1) BR9304780A (enExample)
CA (1) CA2108848A1 (enExample)
CZ (1) CZ284415B6 (enExample)
DE (1) DE69307478T2 (enExample)
DK (1) DK0599114T3 (enExample)
ES (1) ES2097423T3 (enExample)
FI (1) FI935092A7 (enExample)
GR (1) GR3022691T3 (enExample)
HU (1) HU213609B (enExample)
IL (1) IL107614A (enExample)
NO (1) NO304022B1 (enExample)
NZ (1) NZ250194A (enExample)
PH (1) PH30991A (enExample)
PL (1) PL176017B1 (enExample)
RU (1) RU2126385C1 (enExample)
TW (1) TW267161B (enExample)
UY (1) UY23678A1 (enExample)
ZA (1) ZA938478B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
WO1997013518A1 (en) * 1995-10-10 1997-04-17 Marilyn Strube Treatment of pruritus with vitamin d and analogs thereof
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
US5691328A (en) * 1996-02-02 1997-11-25 Clarion Pharmaceuticals Inc. Phosphoethanolamine conjugates of vitamin D compounds
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
DE69813380T2 (de) * 1997-05-02 2003-12-04 Duphar International Research B.V., Weesp Verfahren zur Herstellung von 16-Dehydro Vitamin D Verbindungen
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
JP2017505778A (ja) 2014-01-29 2017-02-23 ヒューメディックス カンパニー，リミテッド ペグ化７−デヒドロコレステロール誘導体
KR101702076B1 (ko) 2015-02-25 2017-02-02 주식회사 휴메딕스 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체
GB202016614D0 (en) 2020-10-20 2020-12-02 King S College London Compounds

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970676A (en) * 1974-10-29 1976-07-20 The Upjohn Company Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
US4116985A (en) * 1976-07-26 1978-09-26 The Upjohn Company Novel method for preparing cholesta-5,7-diene 3β,25-diol and derivatives thereof
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4456553A (en) * 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
JPS63264452A (ja) * 1986-10-20 1988-11-01 Sumitomo Pharmaceut Co Ltd フッ素化ビタミンｄ↓３誘導体
EP0321572B1 (en) * 1987-03-30 1993-06-09 Kuraray Co., Ltd. Pregnane derivatives and process for their preparation
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
WO1990000560A1 (en) * 1988-07-05 1990-01-25 Kuraray Co., Ltd. Steroid compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
CA2042369A1 (en) * 1989-09-11 1991-03-12 Charles D. Pauza Use of vitamin d compounds to inhibit replication of the aids virus
WO1991012238A1 (de) * 1990-02-06 1991-08-22 Schering Aktiengesellschaft Berlin Und Bergkamen Seitenketten-homologe vitamin-d-derivative, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung als arzneimittel
DE4101953A1 (de) * 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
DE4105503A1 (de) * 1991-02-19 1992-08-20 Jenapharm Gmbh Ausgangsverbindungen zur herstellung von calcitriol sowie dessen abkoemmlingen, verfahren zur herstellung dieser ausgangsverbindungen sowie zwischenprodukte fuer dieses verfahren
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
DE69213844T2 (de) * 1991-07-05 1997-04-10 Duphar Int Res Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür

Also Published As

Publication number Publication date
DE69307478D1 (de) 1997-02-27
IL107614A0 (en) 1994-02-27
PH30991A (en) 1997-12-23
CA2108848A1 (en) 1994-05-21
TW267161B (enExample) 1996-01-01
HU9303227D0 (en) 1994-03-28
DE69307478T2 (de) 1997-05-28
EP0599114B1 (en) 1997-01-15
DK0599114T3 (da) 1997-04-14
NO304022B1 (no) 1998-10-12
KR940011443A (ko) 1994-06-21
ATE147728T1 (de) 1997-02-15
IL107614A (en) 1999-09-22
BR9304780A (pt) 1994-07-05
HU213609B (en) 1997-08-28
CZ248993A3 (en) 1994-06-15
JP2502931B2 (ja) 1996-05-29
CN1090573A (zh) 1994-08-10
JPH06199777A (ja) 1994-07-19
AU669222B2 (en) 1996-05-30
ES2097423T3 (es) 1997-04-01
RU2126385C1 (ru) 1999-02-20
FI935092A0 (fi) 1993-11-17
UY23678A1 (es) 1994-05-20
GR3022691T3 (en) 1997-05-31
PL301103A1 (en) 1994-05-30
FI935092L (fi) 1994-05-21
JPH08109191A (ja) 1996-04-30
CZ284415B6 (cs) 1998-11-11
FI935092A7 (fi) 1994-05-21
CN1051762C (zh) 2000-04-26
HUT66022A (en) 1994-08-29
EP0599114A1 (en) 1994-06-01
NO934197D0 (no) 1993-11-19
NO934197L (no) 1994-05-24
AU5069793A (en) 1994-06-02
NZ250194A (en) 1996-01-26
US5342833A (en) 1994-08-30
US5393900A (en) 1995-02-28
PL176017B1 (pl) 1999-03-31
US5747478A (en) 1998-05-05

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