ZA926813B - Imidazolidyl macrolides - Google Patents

Imidazolidyl macrolides

Info

Publication number
ZA926813B
ZA926813B ZA926813A ZA926813A ZA926813B ZA 926813 B ZA926813 B ZA 926813B ZA 926813 A ZA926813 A ZA 926813A ZA 926813 A ZA926813 A ZA 926813A ZA 926813 B ZA926813 B ZA 926813B
Authority
ZA
South Africa
Prior art keywords
diseases
imidazolidyl
macrolides
imidazolidyl macrolides
arylation
Prior art date
Application number
ZA926813A
Other languages
English (en)
Inventor
Mark Goulet
Peter J Sinclair
Frederick Wong
Matthew Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA926813B publication Critical patent/ZA926813B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA926813A 1991-09-09 1992-09-08 Imidazolidyl macrolides ZA926813B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75663391A 1991-09-09 1991-09-09
US07/921,181 US5247076A (en) 1991-09-09 1992-08-04 Imidazolidyl macrolides having immunosuppressive activity
CA002116674A CA2116674C (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides

Publications (1)

Publication Number Publication Date
ZA926813B true ZA926813B (en) 1994-03-07

Family

ID=27169717

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA926813A ZA926813B (en) 1991-09-09 1992-09-08 Imidazolidyl macrolides

Country Status (23)

Country Link
US (2) US5247076A (sk)
EP (1) EP0536896B1 (sk)
JP (1) JP3098032B2 (sk)
AT (1) ATE161266T1 (sk)
AU (1) AU669672B2 (sk)
BG (1) BG98640A (sk)
CA (1) CA2116674C (sk)
CZ (1) CZ47394A3 (sk)
DE (1) DE69223583T2 (sk)
DK (1) DK0536896T3 (sk)
ES (1) ES2111615T3 (sk)
FI (1) FI941084A (sk)
GR (1) GR3025993T3 (sk)
HU (1) HUT67267A (sk)
IL (1) IL103011A (sk)
NO (1) NO940804L (sk)
NZ (1) NZ244154A (sk)
PL (2) PL172637B1 (sk)
RO (1) RO112620B1 (sk)
RU (1) RU2108338C1 (sk)
SK (1) SK28694A3 (sk)
WO (1) WO1993005059A1 (sk)
ZA (1) ZA926813B (sk)

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US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
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WO1994021253A1 (en) * 1993-03-17 1994-09-29 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1995020590A1 (en) * 1994-01-27 1995-08-03 The Trustees Of Columbia University In The City Of New York Enantioselective receptors for amino acid derivatives, and other compounds
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US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5491159A (en) * 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
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US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
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US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
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GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
CA2383451A1 (en) * 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
CA2561249A1 (en) * 2004-03-31 2005-10-20 Lexicon Genetics, Inc. 2-aminomethylthiazole-5-carboxamides as protein kinase modulators
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP5597887B2 (ja) 2006-06-07 2014-10-01 プジョー シトロエン オートモビル エス アー ベンズイミダゾール基を持つモノマーとそのポリマー、そのポリマーを用いたイオン交換膜、燃料電池、燃料電池の使用、電気分解装置
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WO2009089549A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP2839038B1 (en) 2012-04-20 2019-01-16 T2 Biosystems, Inc. Compositions and methods for detection of candida species
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
JP6830907B2 (ja) 2016-01-08 2021-02-17 日本化薬株式会社 マクロライド系免疫抑制剤の高分子誘導体
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
JP7465806B2 (ja) 2018-08-10 2024-04-11 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

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US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
CA2032159A1 (en) * 1989-06-14 1990-12-15 Andrew J. F. Edmunds Heteroatoms-containing tricyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
AU8394291A (en) * 1990-08-18 1992-03-17 Fisons Plc Macrocyclic compounds
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118678A (en) * 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
NZ244154A (en) 1995-05-26
US5344925A (en) 1994-09-06
AU669672B2 (en) 1996-06-20
NO940804D0 (no) 1994-03-08
CZ47394A3 (en) 1994-10-19
CA2116674A1 (en) 1993-03-18
JPH06510303A (ja) 1994-11-17
DE69223583D1 (de) 1998-01-29
PL172789B1 (pl) 1997-11-28
PL172637B1 (pl) 1997-10-31
HU9400687D0 (en) 1994-06-28
DE69223583T2 (de) 1998-07-02
RU2108338C1 (ru) 1998-04-10
GR3025993T3 (en) 1998-04-30
IL103011A (en) 1997-02-18
FI941084A0 (fi) 1994-03-08
IL103011A0 (en) 1993-02-21
SK28694A3 (en) 1994-08-10
HUT67267A (en) 1995-03-28
EP0536896B1 (en) 1997-12-17
BG98640A (en) 1995-05-31
ATE161266T1 (de) 1998-01-15
US5247076A (en) 1993-09-21
AU2660992A (en) 1993-04-05
JP3098032B2 (ja) 2000-10-10
WO1993005059A1 (en) 1993-03-18
FI941084A (fi) 1994-03-08
ES2111615T3 (es) 1998-03-16
NO940804L (no) 1994-05-06
CA2116674C (en) 2002-09-17
RO112620B1 (ro) 1997-11-28
DK0536896T3 (da) 1998-01-19
EP0536896A1 (en) 1993-04-14

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