NO940804L - Imidazolidylmakrolider - Google Patents

Imidazolidylmakrolider

Info

Publication number
NO940804L
NO940804L NO940804A NO940804A NO940804L NO 940804 L NO940804 L NO 940804L NO 940804 A NO940804 A NO 940804A NO 940804 A NO940804 A NO 940804A NO 940804 L NO940804 L NO 940804L
Authority
NO
Norway
Prior art keywords
diseases
arylation
illnesses
alkylation
rejection
Prior art date
Application number
NO940804A
Other languages
English (en)
Other versions
NO940804D0 (no
Inventor
Mark Goulet
Peter J Sinclair
Frederick Wong
Matthew J Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO940804D0 publication Critical patent/NO940804D0/no
Publication of NO940804L publication Critical patent/NO940804L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Imidazolidylmakrolider med den generelle strukturformel (I) CH, H,C CH30 OCH3 er blitt fremstilt fra egnede forløpere ved alkylering og/eller arylering i C- 3'' og C-41' i sykloheksylringen. Disse immunundertrykkende makrolider kan an- vendes i en pattedyrvert for behandling av autoinununsykdommer, smittesykdommer, forhindring av avvisning av fremmed- organtransplantater og/eller beslektede lidelser, syker og sykdommer.
NO940804A 1991-09-09 1994-03-08 Imidazolidylmakrolider NO940804L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75663391A 1991-09-09 1991-09-09
US07/921,181 US5247076A (en) 1991-09-09 1992-08-04 Imidazolidyl macrolides having immunosuppressive activity
CA002116674A CA2116674C (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides
PCT/US1992/007539 WO1993005059A1 (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides

Publications (2)

Publication Number Publication Date
NO940804D0 NO940804D0 (no) 1994-03-08
NO940804L true NO940804L (no) 1994-05-06

Family

ID=27169717

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940804A NO940804L (no) 1991-09-09 1994-03-08 Imidazolidylmakrolider

Country Status (23)

Country Link
US (2) US5247076A (no)
EP (1) EP0536896B1 (no)
JP (1) JP3098032B2 (no)
AT (1) ATE161266T1 (no)
AU (1) AU669672B2 (no)
BG (1) BG98640A (no)
CA (1) CA2116674C (no)
CZ (1) CZ47394A3 (no)
DE (1) DE69223583T2 (no)
DK (1) DK0536896T3 (no)
ES (1) ES2111615T3 (no)
FI (1) FI941084A (no)
GR (1) GR3025993T3 (no)
HU (1) HUT67267A (no)
IL (1) IL103011A (no)
NO (1) NO940804L (no)
NZ (1) NZ244154A (no)
PL (2) PL172789B1 (no)
RO (1) RO112620B1 (no)
RU (1) RU2108338C1 (no)
SK (1) SK28694A3 (no)
WO (1) WO1993005059A1 (no)
ZA (1) ZA926813B (no)

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US5563172A (en) * 1991-09-05 1996-10-08 Abbott Laboratories Macrocyclic amide and urea immunomodulators
US5561137A (en) * 1991-09-05 1996-10-01 Abbott Laboratories Thio-heterocyclic macrolactam immunomodulators
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1994021253A1 (en) * 1993-03-17 1994-09-29 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
AU1689495A (en) * 1994-01-27 1995-08-15 Trustees Of Columbia University In The City Of New York, The Enantioselective receptors for amino acid derivatives, and other compounds
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5491159A (en) * 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
CN100335063C (zh) 1994-10-26 2007-09-05 诺瓦蒂斯有限公司 药物组合物
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6124453A (en) * 1995-07-04 2000-09-26 Novartis Ag Macrolides
EP0848717A1 (en) * 1995-08-24 1998-06-24 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
TR200002771T2 (tr) 1998-03-26 2001-02-21 Fujisawa Pharmaceutical Co.,Ltd. Devamlı salımı olan preparatlar
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
ATE264863T1 (de) * 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
AU2005230846A1 (en) * 2004-03-31 2005-10-20 Lexicon Pharmaceuticals, Inc. 2-aminomethylthiazole-5-carboxamides as protein kinase modulators
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
WO2007141441A1 (fr) * 2006-06-07 2007-12-13 Peugeot Citroën Automobiles S.A. 'monomères et polymères améliorés porteurs de groupements imidazoles et benzimidazoles et membrane à conduction protonique en contenant pour la fabrication d'une pile à combustible'.
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CA2711765A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
WO2017119272A1 (ja) 2016-01-08 2017-07-13 日本化薬株式会社 マクロライド系免疫抑制剤の高分子誘導体
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
EP3834826A4 (en) 2018-08-10 2022-07-27 Koushi Yamaguchi THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN THE MATERNO-FETAL RELATIONSHIP
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

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US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JPH04500372A (ja) * 1989-06-14 1992-01-23 サンド・リミテッド 異種原子含有三環式化合物
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
WO1992003441A1 (en) * 1990-08-18 1992-03-05 Fisons Plc Macrocyclic compounds
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118678A (en) * 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
NZ244154A (en) 1995-05-26
IL103011A0 (en) 1993-02-21
BG98640A (en) 1995-05-31
DE69223583D1 (de) 1998-01-29
FI941084A0 (fi) 1994-03-08
ZA926813B (en) 1994-03-07
ES2111615T3 (es) 1998-03-16
DE69223583T2 (de) 1998-07-02
RO112620B1 (ro) 1997-11-28
US5344925A (en) 1994-09-06
RU2108338C1 (ru) 1998-04-10
PL172637B1 (pl) 1997-10-31
US5247076A (en) 1993-09-21
AU669672B2 (en) 1996-06-20
JP3098032B2 (ja) 2000-10-10
SK28694A3 (en) 1994-08-10
AU2660992A (en) 1993-04-05
CA2116674A1 (en) 1993-03-18
CZ47394A3 (en) 1994-10-19
GR3025993T3 (en) 1998-04-30
HUT67267A (en) 1995-03-28
HU9400687D0 (en) 1994-06-28
NO940804D0 (no) 1994-03-08
ATE161266T1 (de) 1998-01-15
JPH06510303A (ja) 1994-11-17
DK0536896T3 (da) 1998-01-19
WO1993005059A1 (en) 1993-03-18
EP0536896A1 (en) 1993-04-14
EP0536896B1 (en) 1997-12-17
FI941084A (fi) 1994-03-08
CA2116674C (en) 2002-09-17
PL172789B1 (pl) 1997-11-28
IL103011A (en) 1997-02-18

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