ZA922807B - Substituted 3-(pyridinylamino)-indoles and benzo(b)thiophenes,a process for their preparation and their use as medicaments - Google Patents
Substituted 3-(pyridinylamino)-indoles and benzo(b)thiophenes,a process for their preparation and their use as medicamentsInfo
- Publication number
- ZA922807B ZA922807B ZA922807A ZA922807A ZA922807B ZA 922807 B ZA922807 B ZA 922807B ZA 922807 A ZA922807 A ZA 922807A ZA 922807 A ZA922807 A ZA 922807A ZA 922807 B ZA922807 B ZA 922807B
- Authority
- ZA
- South Africa
- Prior art keywords
- loweralkyl
- hydrogen
- chem
- arylloweralkyl
- pyridinylamino
- Prior art date
Links
- 125000005605 benzo group Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- UWEMLVAIJQLZNQ-UHFFFAOYSA-N n-pyridin-2-yl-1h-indol-3-amine Chemical class C=1NC2=CC=CC=C2C=1NC1=CC=CC=N1 UWEMLVAIJQLZNQ-UHFFFAOYSA-N 0.000 title 1
- 229930192474 thiophene Natural products 0.000 title 1
- 150000003577 thiophenes Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 230000001800 adrenalinergic effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229940125683 antiemetic agent Drugs 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
- 229940127236 atypical antipsychotics Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 208000022821 personality disease Diseases 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000000862 serotonergic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/688,964 US5177088A (en) | 1991-04-17 | 1991-04-17 | Substituted 3-(pyridinylamino)-indoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA922807B true ZA922807B (en) | 1992-11-25 |
Family
ID=24766519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA922807A ZA922807B (en) | 1991-04-17 | 1992-04-16 | Substituted 3-(pyridinylamino)-indoles and benzo(b)thiophenes,a process for their preparation and their use as medicaments |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5177088A (no) |
| EP (1) | EP0509402B1 (no) |
| JP (1) | JP2617650B2 (no) |
| KR (1) | KR100254027B1 (no) |
| AT (1) | ATE161840T1 (no) |
| AU (1) | AU655253B2 (no) |
| BG (1) | BG61034B1 (no) |
| CA (1) | CA2066332C (no) |
| CS (1) | CS117192A3 (no) |
| DE (1) | DE69223837T2 (no) |
| DK (1) | DK0509402T3 (no) |
| ES (1) | ES2111580T3 (no) |
| FI (1) | FI105096B (no) |
| GR (1) | GR3026317T3 (no) |
| HU (1) | HU215113B (no) |
| IE (1) | IE921235A1 (no) |
| IL (1) | IL101599A (no) |
| MX (1) | MX9201759A (no) |
| NO (1) | NO180486C (no) |
| NZ (1) | NZ242359A (no) |
| PL (1) | PL168905B1 (no) |
| RO (1) | RO109847B1 (no) |
| RU (1) | RU2060254C1 (no) |
| TW (1) | TW200477B (no) |
| ZA (1) | ZA922807B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264442A (en) * | 1990-08-13 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| US5356910A (en) | 1993-07-19 | 1994-10-18 | Hoechst-Roussel Pharmaceuticals Inc. | Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder |
| DK0833820T3 (da) * | 1995-06-06 | 2001-04-17 | Aventis Pharma Inc | Benzisoxazol- og indazolderivater som antipsykotiske midler |
| US5668154A (en) * | 1995-06-06 | 1997-09-16 | Hoechst Marion Roussel Inc. | Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles |
| AU720466B2 (en) * | 1996-12-27 | 2000-06-01 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines and related compounds |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| MXPA02002694A (es) * | 1999-09-14 | 2002-07-30 | Aventis Pharm Prod Inc | Derivados de benzisoxazolil-, piridoisoxazolil-y benzotienil-fenoxi utiles como antagonistas de d4. |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| DE10029371A1 (de) | 2000-06-20 | 2002-01-03 | Merck Patent Gmbh | Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| BRPI0511722A (pt) | 2004-06-01 | 2008-01-08 | Hoffmann La Roche | 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina |
| RU2008120141A (ru) | 2005-11-30 | 2010-01-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | 3-амино-2-арилпропилазаиндолы и их применения |
| JP2009517430A (ja) * | 2005-11-30 | 2009-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ３−アミノ−１−アリールプロピルインドール類及びアザ置換インドール類 |
| EP2351737A1 (en) * | 2005-11-30 | 2011-08-03 | F. Hoffmann-La Roche AG | 3-Amino-1-arylpropyl indoles and aza-substituted indoles |
| US20100291533A1 (en) * | 2008-01-04 | 2010-11-18 | Soon Ha Kim | Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166987D1 (en) * | 1980-09-18 | 1984-12-06 | Asahi Chemical Ind | 3-aminoindazole derivatives and process for preparation thereof |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| US4970218A (en) * | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
-
1991
- 1991-04-17 US US07/688,964 patent/US5177088A/en not_active Expired - Lifetime
-
1992
- 1992-04-09 AT AT92106162T patent/ATE161840T1/de not_active IP Right Cessation
- 1992-04-09 BG BG96202A patent/BG61034B1/bg unknown
- 1992-04-09 ES ES92106162T patent/ES2111580T3/es not_active Expired - Lifetime
- 1992-04-09 EP EP92106162A patent/EP0509402B1/en not_active Expired - Lifetime
- 1992-04-09 DK DK92106162T patent/DK0509402T3/da active
- 1992-04-09 DE DE69223837T patent/DE69223837T2/de not_active Expired - Fee Related
- 1992-04-14 NZ NZ242359A patent/NZ242359A/en unknown
- 1992-04-14 MX MX9201759A patent/MX9201759A/es unknown
- 1992-04-14 RO RO92-200519A patent/RO109847B1/ro unknown
- 1992-04-15 FI FI921693A patent/FI105096B/fi active
- 1992-04-15 IL IL10159992A patent/IL101599A/en not_active IP Right Cessation
- 1992-04-15 NO NO921505A patent/NO180486C/no unknown
- 1992-04-15 PL PL92294239A patent/PL168905B1/pl unknown
- 1992-04-16 CS CS921171A patent/CS117192A3/cs unknown
- 1992-04-16 ZA ZA922807A patent/ZA922807B/xx unknown
- 1992-04-16 RU SU925011369A patent/RU2060254C1/ru active
- 1992-04-16 KR KR1019920006338A patent/KR100254027B1/ko not_active IP Right Cessation
- 1992-04-16 IE IE123592A patent/IE921235A1/en not_active IP Right Cessation
- 1992-04-16 HU HU9201297A patent/HU215113B/hu not_active IP Right Cessation
- 1992-04-16 CA CA002066332A patent/CA2066332C/en not_active Expired - Fee Related
- 1992-04-16 JP JP4096304A patent/JP2617650B2/ja not_active Expired - Fee Related
- 1992-04-21 AU AU15121/92A patent/AU655253B2/en not_active Ceased
- 1992-04-24 TW TW081103218A patent/TW200477B/zh active
-
1998
- 1998-03-11 GR GR980400508T patent/GR3026317T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
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| IL101599A0 (en) | Substituted 3-(pyridinylamino)-indoles and benzo(b)thiophenes,a process for their preparation and their use as medicaments | |
| SG48059A1 (en) | 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments | |
| AU665637B2 (en) | Substituted (pyridinylamino)-benzisoxazoles and -benzol{b}thiophenes, a process for their preparation and their use as medicaments | |
| GR3025774T3 (en) | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | |
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