DE69223837D1 - Substituierte 3-(Pyridinylamino)-indole und Benzo[b]thiophene, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents
Substituierte 3-(Pyridinylamino)-indole und Benzo[b]thiophene, ein Verfahren zu ihrer Herstellung und ihre Verwendung als ArzneimittelInfo
- Publication number
- DE69223837D1 DE69223837D1 DE69223837T DE69223837T DE69223837D1 DE 69223837 D1 DE69223837 D1 DE 69223837D1 DE 69223837 T DE69223837 T DE 69223837T DE 69223837 T DE69223837 T DE 69223837T DE 69223837 D1 DE69223837 D1 DE 69223837D1
- Authority
- DE
- Germany
- Prior art keywords
- loweralkyl
- hydrogen
- chem
- arylloweralkyl
- pyridinylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/688,964 US5177088A (en) | 1991-04-17 | 1991-04-17 | Substituted 3-(pyridinylamino)-indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69223837D1 true DE69223837D1 (de) | 1998-02-12 |
| DE69223837T2 DE69223837T2 (de) | 1998-06-25 |
Family
ID=24766519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69223837T Expired - Fee Related DE69223837T2 (de) | 1991-04-17 | 1992-04-09 | Substituierte 3-(Pyridinylamino)-indole und Benzo[b]thiophene, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5177088A (de) |
| EP (1) | EP0509402B1 (de) |
| JP (1) | JP2617650B2 (de) |
| KR (1) | KR100254027B1 (de) |
| AT (1) | ATE161840T1 (de) |
| AU (1) | AU655253B2 (de) |
| BG (1) | BG61034B1 (de) |
| CA (1) | CA2066332C (de) |
| CS (1) | CS117192A3 (de) |
| DE (1) | DE69223837T2 (de) |
| DK (1) | DK0509402T3 (de) |
| ES (1) | ES2111580T3 (de) |
| FI (1) | FI105096B (de) |
| GR (1) | GR3026317T3 (de) |
| HU (1) | HU215113B (de) |
| IE (1) | IE921235A1 (de) |
| IL (1) | IL101599A (de) |
| MX (1) | MX9201759A (de) |
| NO (1) | NO180486C (de) |
| NZ (1) | NZ242359A (de) |
| PL (1) | PL168905B1 (de) |
| RO (1) | RO109847B1 (de) |
| RU (1) | RU2060254C1 (de) |
| TW (1) | TW200477B (de) |
| ZA (1) | ZA922807B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264442A (en) * | 1990-08-13 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| US5356910A (en) | 1993-07-19 | 1994-10-18 | Hoechst-Roussel Pharmaceuticals Inc. | Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder |
| DK0833820T3 (da) * | 1995-06-06 | 2001-04-17 | Aventis Pharma Inc | Benzisoxazol- og indazolderivater som antipsykotiske midler |
| US5668154A (en) * | 1995-06-06 | 1997-09-16 | Hoechst Marion Roussel Inc. | Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles |
| AU720466B2 (en) * | 1996-12-27 | 2000-06-01 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines and related compounds |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| MXPA02002694A (es) * | 1999-09-14 | 2002-07-30 | Aventis Pharm Prod Inc | Derivados de benzisoxazolil-, piridoisoxazolil-y benzotienil-fenoxi utiles como antagonistas de d4. |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| DE10029371A1 (de) | 2000-06-20 | 2002-01-03 | Merck Patent Gmbh | Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| BRPI0511722A (pt) | 2004-06-01 | 2008-01-08 | Hoffmann La Roche | 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina |
| RU2008120141A (ru) | 2005-11-30 | 2010-01-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | 3-амино-2-арилпропилазаиндолы и их применения |
| JP2009517430A (ja) * | 2005-11-30 | 2009-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ３−アミノ−１−アリールプロピルインドール類及びアザ置換インドール類 |
| EP2351737A1 (de) * | 2005-11-30 | 2011-08-03 | F. Hoffmann-La Roche AG | 3-Amino-1-arylpropyl-Indole und aza-substituierte Indole |
| US20100291533A1 (en) * | 2008-01-04 | 2010-11-18 | Soon Ha Kim | Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166987D1 (en) * | 1980-09-18 | 1984-12-06 | Asahi Chemical Ind | 3-aminoindazole derivatives and process for preparation thereof |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| US4970218A (en) * | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
-
1991
- 1991-04-17 US US07/688,964 patent/US5177088A/en not_active Expired - Lifetime
-
1992
- 1992-04-09 AT AT92106162T patent/ATE161840T1/de not_active IP Right Cessation
- 1992-04-09 BG BG96202A patent/BG61034B1/bg unknown
- 1992-04-09 ES ES92106162T patent/ES2111580T3/es not_active Expired - Lifetime
- 1992-04-09 EP EP92106162A patent/EP0509402B1/de not_active Expired - Lifetime
- 1992-04-09 DK DK92106162T patent/DK0509402T3/da active
- 1992-04-09 DE DE69223837T patent/DE69223837T2/de not_active Expired - Fee Related
- 1992-04-14 NZ NZ242359A patent/NZ242359A/en unknown
- 1992-04-14 MX MX9201759A patent/MX9201759A/es unknown
- 1992-04-14 RO RO92-200519A patent/RO109847B1/ro unknown
- 1992-04-15 FI FI921693A patent/FI105096B/fi active
- 1992-04-15 IL IL10159992A patent/IL101599A/en not_active IP Right Cessation
- 1992-04-15 NO NO921505A patent/NO180486C/no unknown
- 1992-04-15 PL PL92294239A patent/PL168905B1/pl unknown
- 1992-04-16 CS CS921171A patent/CS117192A3/cs unknown
- 1992-04-16 ZA ZA922807A patent/ZA922807B/xx unknown
- 1992-04-16 RU SU925011369A patent/RU2060254C1/ru active
- 1992-04-16 KR KR1019920006338A patent/KR100254027B1/ko not_active IP Right Cessation
- 1992-04-16 IE IE123592A patent/IE921235A1/en not_active IP Right Cessation
- 1992-04-16 HU HU9201297A patent/HU215113B/hu not_active IP Right Cessation
- 1992-04-16 CA CA002066332A patent/CA2066332C/en not_active Expired - Fee Related
- 1992-04-16 JP JP4096304A patent/JP2617650B2/ja not_active Expired - Fee Related
- 1992-04-21 AU AU15121/92A patent/AU655253B2/en not_active Ceased
- 1992-04-24 TW TW081103218A patent/TW200477B/zh active
-
1998
- 1998-03-11 GR GR980400508T patent/GR3026317T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69223837T2 (de) | Substituierte 3-(Pyridinylamino)-indole und Benzo[b]thiophene, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
| SG48059A1 (en) | 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments | |
| ATE160346T1 (de) | Substituierte pyridinylamino-1h-indole, 1h- indazole, 2h-indazole, benzo(b)thiophen und 1,2- benzisothiazole, verfahren zu ihren herstellung und ihre verwendung als arzneimittel | |
| DE69114404D1 (de) | 1-(Pyridinylalkyl)-1H-indole, -indoline und Analoge. | |
| DE69201424T2 (de) | Substituierte 3-Amino-2,3,4,5-Tetrahydro-1-Aryloxy-3-Benzazepine, Verfahren zu ihrer Herstellung und ihre Verwendung als Modulatoren der Neurotransmitterfunktion. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |