ZA895778B - Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial gents - Google Patents

Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial gents

Info

Publication number
ZA895778B
ZA895778B ZA895778A ZA895778A ZA895778B ZA 895778 B ZA895778 B ZA 895778B ZA 895778 A ZA895778 A ZA 895778A ZA 895778 A ZA895778 A ZA 895778A ZA 895778 B ZA895778 B ZA 895778B
Authority
ZA
South Africa
Prior art keywords
gents
antibacterial
derivatives useful
aminomethyloxooxazolidinyl
arylbenzene derivatives
Prior art date
Application number
ZA895778A
Other languages
English (en)
Inventor
Randall Kent Carlson
Kent Carlson Randall
Chung-Ho Park
Park Chung-Ho
Walter Adelman Gregory
Adelman Gregory Walter
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA895778B publication Critical patent/ZA895778B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • C07D263/24Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA895778A 1988-07-29 1989-07-28 Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial gents ZA895778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/225,809 US4948801A (en) 1988-07-29 1988-07-29 Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents

Publications (1)

Publication Number Publication Date
ZA895778B true ZA895778B (en) 1991-03-27

Family

ID=22846337

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895778A ZA895778B (en) 1988-07-29 1989-07-28 Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial gents

Country Status (16)

Country Link
US (1) US4948801A (ko)
EP (1) EP0352781A3 (ko)
JP (1) JP2899319B2 (ko)
KR (1) KR910002817A (ko)
AU (1) AU622465B2 (ko)
CA (1) CA1337526C (ko)
DK (1) DK374389A (ko)
FI (1) FI893618A (ko)
HU (1) HUT58062A (ko)
IE (1) IE892438L (ko)
IL (1) IL91129A0 (ko)
MY (1) MY104096A (ko)
NO (1) NO893076L (ko)
NZ (1) NZ230108A (ko)
PT (1) PT91315A (ko)
ZA (1) ZA895778B (ko)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
DK0610265T3 (da) * 1991-11-01 1997-06-09 Upjohn Co Substituerede aryl- og heteroarylphenyloxazolidioner, som kan anvendes som antibakterielle midler
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
ATE161833T1 (de) * 1992-12-08 1998-01-15 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
KR100312903B1 (ko) * 1993-11-22 2002-02-28 로렌스 티. 마이젠헬더 치환된-하이드록시아세틸피페라진페닐옥사졸리디논의에스테르
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
EP0788498B1 (en) * 1994-10-26 2001-08-16 PHARMACIA & UPJOHN COMPANY Phenyloxazolidinone antimicrobials
DK0710657T3 (da) * 1994-11-02 1999-05-25 Merck Patent Gmbh Adhæsionsreceptor-antagonister
WO1996015130A1 (en) * 1994-11-15 1996-05-23 Pharmacia + Upjohn Company Bicyclic oxazine and thiazine oxazolidinone antibacterials
US6696459B1 (en) * 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5693647A (en) * 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
ES2163004T3 (es) * 1995-02-03 2002-01-16 Upjohn Co Feniloxazolidinona sustituida por un anillo heteroaromatico como agente antimicrobiano.
KR100463771B1 (ko) * 1995-05-11 2005-05-16 파마시아 앤드 업존 캄파니 엘엘씨 스피로환식또는이환식디아지닐또는카바지닐옥사졸리디논
WO1997009328A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) * 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9604301D0 (en) * 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
CN1167701C (zh) * 1996-04-11 2004-09-22 法玛西雅厄普约翰美国公司 制备噁唑烷酮胺的方法
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
PT920421E (pt) * 1996-08-21 2003-03-31 Upjohn Co Derivados de isoxazolina uteis como agentes antimicrobianos
WO1998054161A1 (en) 1997-05-30 1998-12-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
EP0994874A1 (en) * 1997-07-11 2000-04-26 PHARMACIA & UPJOHN COMPANY Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999024393A1 (en) 1997-11-07 1999-05-20 Pharmacia & Upjohn Company Process to produce oxazolidinones
CA2303959A1 (en) * 1997-11-12 1999-05-20 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) * 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6083967A (en) 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
JP2002501059A (ja) 1998-01-23 2002-01-15 ファルマシア・アンド・アップジョン・カンパニー オキサゾリジノンの組合せライブラリー、組成物および調製方法
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1054874B1 (en) * 1998-02-13 2002-08-28 PHARMACIA & UPJOHN COMPANY Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
US6617339B1 (en) 1998-06-05 2003-09-09 Syngenta Limited Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
WO2000029396A1 (de) * 1998-11-17 2000-05-25 Bayer Aktiengesellschaft Neue substituierte phenyloxazolidon-derivate
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
KR100333492B1 (ko) * 1999-05-27 2002-04-25 박호군 이소옥사졸릴 메틸렌 옥사졸리디논 유도체 및 이의 제조방법
KR100333493B1 (ko) * 1999-05-27 2002-04-25 박호군 이소옥사졸릴 카르보닐 옥사졸리디논 유도체 및 이의 제조방법
NZ516853A (en) * 1999-07-28 2003-11-28 Upjohn Co Oxazolidinones and their use as anti-infectives
ATE337002T1 (de) * 1999-09-13 2006-09-15 Insite Vision Inc Topische behandlung zur vorbeugung von augeninfektionen
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
US6451345B1 (en) 2000-01-20 2002-09-17 Eurand Pharmaceuticals Ltd. Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
US6734307B2 (en) 2000-07-17 2004-05-11 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2002032857A1 (en) 2000-10-17 2002-04-25 Pharmacia & Upjohn Company Methods of producing oxazolidinone compounds
CA2424402A1 (en) * 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
MXPA04002303A (es) 2001-09-11 2004-06-29 Astrazeneca Ab Oxazolidinona y/o isoxazolina como agentes antibacterianos.
AU2002339721A1 (en) * 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
CA2507468A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
GB0306358D0 (en) 2003-03-20 2003-04-23 Astrazeneca Ab Chemical compounds
AR044152A1 (es) 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
WO2005070904A2 (en) * 2003-06-03 2005-08-04 Rib-X Pharmaceutical, Inc. Sulfonamide compounds and methods of making and using the same
AR045690A1 (es) * 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
US8324398B2 (en) * 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
KR20060113625A (ko) 2003-07-02 2006-11-02 머크 앤드 캄파니 인코포레이티드 시클로프로필기 치환된 옥사졸리디논 항생제 및 그의유도체
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
EP1660465B1 (en) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリールオキサゾリジノンの合成方法
WO2005012270A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
JP2007514782A (ja) * 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
JP2008508271A (ja) * 2004-07-28 2008-03-21 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリール複素環式化合物ならびにその化合物を製造および使用する方法
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) * 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
CA2602073A1 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
WO2006133397A2 (en) 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
DE102005045518A1 (de) * 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
NZ567092A (en) 2005-10-04 2011-05-27 Bayer Schering Pharma Ag Novel polymorphous form and the amorphous form of 5-chloro-N-({ (5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
WO2007102082A1 (en) * 2006-03-09 2007-09-13 Glenmark Pharmaceuticals Limited High oxazolidinone content solid dosage forms
WO2007133803A2 (en) * 2006-05-15 2007-11-22 Rib-X Pharmaceuticals, Inc. Treatment of mycobacterial infections
US8633175B2 (en) 2006-08-09 2014-01-21 Glaxosmithkline Llc Compounds as antagonists or inverse agonists at opioid receptors
AU2009228293B2 (en) 2008-03-26 2012-11-08 Tennor Therapeutics (Suzhou) Limited Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
TW201004958A (en) * 2008-06-24 2010-02-01 Res Found Itsuu Lab Oxazolidinone derivatives having a fused ring
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR101674146B1 (ko) * 2008-10-10 2016-11-08 머크 샤프 앤드 돔 코포레이션 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 R)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
JP2014500247A (ja) 2010-11-03 2014-01-09 ウォックハート リミテッド リン酸モノ−(1−{4−[(s)―5−(アセチルアミノメチル)−2−オキソ−オキサゾリジン−3−イル]−2,6−ジフルオロフェニル}−4−メトキシメチルピペリジン−4−イル)エステルの調製方法
CN103896963B (zh) * 2012-12-26 2017-06-09 中国科学院上海药物研究所 苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
ITRM20130155A1 (it) * 2013-03-15 2014-09-16 I E Me S T Istituto Euro Mediter Raneo Di Scien Nuovi composti 1,2,4-ossadiazolici attivi contro patogeni gram-positivi.
US9862710B2 (en) 2013-03-15 2018-01-09 Istituto Euro Mediterraneo Di Scienza E Tecnologia 1,2,4-oxadiazol compounds active against gram-positive pathogens
US9920039B2 (en) 2013-03-15 2018-03-20 Università Degli Studi Di Milano—Bicocca 1,2,4-Oxadiazol compounds active against gram-positive pathogens
CN103965183B (zh) * 2014-03-17 2017-05-03 上海应用技术学院 一种含氟噁唑烷酮类化合物及其制备方法和应用
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3010873A (en) * 1956-10-03 1961-11-28 Maggioni & C Spa alpha-[(p-chlorophenyl)-alpha-phenyl]-4-pyridyl carbinol as a potentiating agent
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
EP0316594B1 (en) * 1987-10-21 1993-09-29 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
NO893076D0 (no) 1989-07-28
EP0352781A3 (en) 1990-07-11
CA1337526C (en) 1995-11-07
JP2899319B2 (ja) 1999-06-02
US4948801A (en) 1990-08-14
EP0352781A2 (en) 1990-01-31
AU3911589A (en) 1990-02-01
PT91315A (pt) 1990-02-08
DK374389A (da) 1990-01-30
FI893618A (fi) 1990-01-30
NZ230108A (en) 1991-10-25
IE892438L (en) 1990-01-29
FI893618A0 (fi) 1989-07-28
IL91129A0 (en) 1990-03-19
MY104096A (en) 1993-11-30
HUT58062A (en) 1992-01-28
JPH02124877A (ja) 1990-05-14
AU622465B2 (en) 1992-04-09
DK374389D0 (da) 1989-07-28
KR910002817A (ko) 1991-02-26
NO893076L (no) 1990-01-30

Similar Documents

Publication Publication Date Title
ZA895778B (en) Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial gents
AP9000175A0 (en) 3-substituted-2-oxindole derivatives
EP0430709A3 (en) Benzthiophen derivatives
EP0431421A3 (en) Heteroarylsubstituted pyridinylpyrimidin derivatives
GB2229723B (en) Thieno-triazolo-diazepine derivatives
AU6670090A (en) Substituted pyrimidobenzimidazole derivatives
EP0420608A3 (en) Cephalosporin derivatives
GB2231330B (en) Thieno-triazolo-diazepine derivatives
EP0431424A3 (en) Pyridinylpyrimidin derivatives
GB2229724B (en) Thieno-triazolo-diazepine derivatives
EP0479951A4 (en) Bis-acyloxymethyl derivatives
EP0411636A3 (en) Piperidylthiocarbapenem derivatives
GB8918275D0 (en) Fluoro-chloro-benzene derivatives
GB9015831D0 (en) Dihydropyrimidothiazine derivatives
EP0438686A3 (en) Triazolylmethyl-cyclopropyl derivatives
GB2238310B (en) Selenophen derivatives
ZA903608B (en) Substituted azacyclohexyl derivatives
GB8919100D0 (en) Fluoro-chloro-benzene derivatives
EP0409296A3 (en) Cardanolactam derivatives
ZA904951B (en) Substituted bicycloheptandione derivatives
ZA905740B (en) Substituted aminoalkoxybenzene derivatives
HRP930493A2 (en) Substituted aminoalkylbenzene derivatives
ZA909138B (en) Substituted pyrimidobenzimidazole derivatives
IE883166L (en) Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
IE893806L (en) Chitosan derivatives