AU6670090A - Substituted pyrimidobenzimidazole derivatives - Google Patents

Substituted pyrimidobenzimidazole derivatives

Info

Publication number
AU6670090A
AU6670090A AU66700/90A AU6670090A AU6670090A AU 6670090 A AU6670090 A AU 6670090A AU 66700/90 A AU66700/90 A AU 66700/90A AU 6670090 A AU6670090 A AU 6670090A AU 6670090 A AU6670090 A AU 6670090A
Authority
AU
Australia
Prior art keywords
pyrimidobenzimidazole
derivatives
substituted
substituted pyrimidobenzimidazole
pyrimidobenzimidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU66700/90A
Other versions
AU640708B2 (en
Inventor
Christian Hubschwerlen
Ivan Kompis
Jean-Luc Specklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU6670090A publication Critical patent/AU6670090A/en
Application granted granted Critical
Publication of AU640708B2 publication Critical patent/AU640708B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU66700/90A 1989-11-21 1990-11-16 Substituted pyrimidobenzimidazole derivatives Ceased AU640708B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH4165/89 1989-11-21
CH416589 1989-11-21
CH2688/90 1990-08-17
CH268890 1990-08-17
CH281790 1990-08-30
CH2817/90 1990-08-30

Publications (2)

Publication Number Publication Date
AU6670090A true AU6670090A (en) 1991-07-11
AU640708B2 AU640708B2 (en) 1993-09-02

Family

ID=27173847

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66700/90A Ceased AU640708B2 (en) 1989-11-21 1990-11-16 Substituted pyrimidobenzimidazole derivatives

Country Status (6)

Country Link
EP (1) EP0433648A1 (en)
JP (1) JPH03170481A (en)
AU (1) AU640708B2 (en)
CA (1) CA2028530A1 (en)
IE (1) IE904189A1 (en)
NZ (1) NZ236109A (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201261A3 (en) * 1999-05-21 2003-12-29 Scios Inc Sunnyvale Indole-type derivatives as inhibitors of p38 kinase and pharmaceutical compositions containing them
WO2003105846A1 (en) 2002-06-13 2003-12-24 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (en) 2003-01-31 2005-07-13 Vertex Pharma GIRASA INHIBITORS AND USES OF THE SAME
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
CN103384666A (en) 2011-01-14 2013-11-06 沃泰克斯药物股份有限公司 Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea
JP6006235B2 (en) 2011-01-14 2016-10-12 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Process for making gyrase and topoisomerase IV inhibitors
KR101897952B1 (en) 2011-01-14 2018-09-12 스페로 트리넴, 인코포레이티드 Pyrimidine gyrase and topoisomerase iv inhibitors
SG191927A1 (en) 2011-01-14 2013-08-30 Vertex Pharma Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
ES2576298T3 (en) 2011-06-20 2016-07-06 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
WO2014015105A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
CN112574219A (en) * 2021-01-31 2021-03-30 湖北大学 Synthesis method of benzimidazolopyrimidinone derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
DE2855883A1 (en) * 1978-12-23 1980-07-10 Hoechst Ag METHOD FOR PRODUCING AMINOBENZIMIDAZOLONES- (2)
DE2930333A1 (en) * 1979-07-26 1981-02-19 Basf Ag Benzimidazo-pyrimidine benzindole mercapto-cyanine cpds. - useful for colouring textiles and plastics, e.g. polyamide, polyester or polystyrene
DE3807084A1 (en) * 1988-03-04 1989-09-14 Knoll Ag NEW BENZIMIDAZO (1,2-C) CHINAZOLINE, THEIR PRODUCTION AND USE

Also Published As

Publication number Publication date
NZ236109A (en) 1993-05-26
EP0433648A1 (en) 1991-06-26
AU640708B2 (en) 1993-09-02
CA2028530A1 (en) 1991-05-22
IE904189A1 (en) 1991-05-22
JPH03170481A (en) 1991-07-24

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