NZ236109A - Substituted pyrimidobenzimidazole derivatives and antibacterial compositions - Google Patents
Substituted pyrimidobenzimidazole derivatives and antibacterial compositionsInfo
- Publication number
- NZ236109A NZ236109A NZ236109A NZ23610990A NZ236109A NZ 236109 A NZ236109 A NZ 236109A NZ 236109 A NZ236109 A NZ 236109A NZ 23610990 A NZ23610990 A NZ 23610990A NZ 236109 A NZ236109 A NZ 236109A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pyrimidobenzimidazole
- derivatives
- substituted
- antibacterial compositions
- antibacterial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH416589 | 1989-11-21 | ||
CH268890 | 1990-08-17 | ||
CH281790 | 1990-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ236109A true NZ236109A (en) | 1993-05-26 |
Family
ID=27173847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ236109A NZ236109A (en) | 1989-11-21 | 1990-11-16 | Substituted pyrimidobenzimidazole derivatives and antibacterial compositions |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0433648A1 (en) |
JP (1) | JPH03170481A (en) |
AU (1) | AU640708B2 (en) |
CA (1) | CA2028530A1 (en) |
IE (1) | IE904189A1 (en) |
NZ (1) | NZ236109A (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU772295B2 (en) * | 1999-05-21 | 2004-04-22 | Scios Inc. | Indole-type derivatives as inhibitors of p38 kinase |
MXPA04012628A (en) | 2002-06-13 | 2005-03-23 | Patricia Olivershaffer | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections. |
US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US7618974B2 (en) | 2003-01-31 | 2009-11-17 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
AR042956A1 (en) | 2003-01-31 | 2005-07-13 | Vertex Pharma | GIRASA INHIBITORS AND USES OF THE SAME |
US7582641B2 (en) | 2003-01-31 | 2009-09-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US8404852B2 (en) | 2003-01-31 | 2013-03-26 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
AU2012205419B2 (en) | 2011-01-14 | 2016-12-15 | Spero Therapeutics, Inc. | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea |
AU2012205420B2 (en) | 2011-01-14 | 2016-12-08 | Spero Therapeutics, Inc. | Process of making gyrase and topoisomerase IV inhibitors |
TW201309676A (en) | 2011-01-14 | 2013-03-01 | Vertex Pharma | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl]-1H-benzimidazol-2-yl]urea |
EP2663557B1 (en) | 2011-01-14 | 2015-05-27 | Vertex Pharmaceuticals Incorporated | Pyrimidine gyrase and topoisomerase iv inhibitors |
JP5977344B2 (en) | 2011-06-20 | 2016-08-24 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Phosphate esters of gyrase and topoisomerase inhibitors |
WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
CN112574219A (en) * | 2021-01-31 | 2021-03-30 | 湖北大学 | Synthesis method of benzimidazolopyrimidinone derivative |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
DE2855883A1 (en) * | 1978-12-23 | 1980-07-10 | Hoechst Ag | METHOD FOR PRODUCING AMINOBENZIMIDAZOLONES- (2) |
DE2930333A1 (en) * | 1979-07-26 | 1981-02-19 | Basf Ag | Benzimidazo-pyrimidine benzindole mercapto-cyanine cpds. - useful for colouring textiles and plastics, e.g. polyamide, polyester or polystyrene |
DE3807084A1 (en) * | 1988-03-04 | 1989-09-14 | Knoll Ag | NEW BENZIMIDAZO (1,2-C) CHINAZOLINE, THEIR PRODUCTION AND USE |
-
1990
- 1990-10-25 CA CA002028530A patent/CA2028530A1/en not_active Abandoned
- 1990-11-13 EP EP90121665A patent/EP0433648A1/en not_active Withdrawn
- 1990-11-15 JP JP2307348A patent/JPH03170481A/en active Pending
- 1990-11-16 NZ NZ236109A patent/NZ236109A/en unknown
- 1990-11-16 AU AU66700/90A patent/AU640708B2/en not_active Ceased
- 1990-11-20 IE IE418990A patent/IE904189A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0433648A1 (en) | 1991-06-26 |
AU640708B2 (en) | 1993-09-02 |
IE904189A1 (en) | 1991-05-22 |
CA2028530A1 (en) | 1991-05-22 |
JPH03170481A (en) | 1991-07-24 |
AU6670090A (en) | 1991-07-11 |
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