ZA884952B - New pentasaccharides - Google Patents

New pentasaccharides

Info

Publication number
ZA884952B
ZA884952B ZA884952A ZA884952A ZA884952B ZA 884952 B ZA884952 B ZA 884952B ZA 884952 A ZA884952 A ZA 884952A ZA 884952 A ZA884952 A ZA 884952A ZA 884952 B ZA884952 B ZA 884952B
Authority
ZA
South Africa
Prior art keywords
pentasaccharides
new
activity
new pentasaccharides
inactivate thrombin
Prior art date
Application number
ZA884952A
Other languages
English (en)
Inventor
Adriaan Anton Van Boeckel Constant
Beetz Tom
Petitou Maurice
Original Assignee
Akzo N.V.
Sanofi S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo N.V., Sanofi S.A. filed Critical Akzo N.V.
Publication of ZA884952B publication Critical patent/ZA884952B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
ZA884952A 1987-07-20 1988-07-08 New pentasaccharides ZA884952B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87201383A EP0300099A1 (fr) 1987-07-20 1987-07-20 Pentasaccharides

Publications (1)

Publication Number Publication Date
ZA884952B true ZA884952B (en) 1989-01-13

Family

ID=8197647

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA884952A ZA884952B (en) 1987-07-20 1988-07-08 New pentasaccharides

Country Status (16)

Country Link
US (1) US4841041A (fr)
EP (2) EP0300099A1 (fr)
JP (1) JP2703777B2 (fr)
KR (1) KR970011304B1 (fr)
AT (1) ATE76875T1 (fr)
AU (1) AU603236B2 (fr)
CA (1) CA1313867C (fr)
DE (1) DE3871637T2 (fr)
DK (1) DK171678B1 (fr)
ES (1) ES2043786T3 (fr)
FI (1) FI90242C (fr)
GR (1) GR3005518T3 (fr)
IE (1) IE60006B1 (fr)
NZ (1) NZ225453A (fr)
PT (1) PT88034B (fr)
ZA (1) ZA884952B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333243A3 (fr) * 1988-03-10 1989-09-27 Akzo N.V. Antigène K5 sulfaté et ses fragments
US5382570A (en) * 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
EP0454220B1 (fr) * 1990-04-23 1993-08-18 Akzo Nobel N.V. Dérivés d'hydrates de carbone comprenant une unité trisaccharide
US5529985A (en) * 1990-04-23 1996-06-25 Akzo Nobel Nv Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
US5668274A (en) * 1991-04-23 1997-09-16 Akzo Nobel N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2729574B1 (fr) * 1995-01-24 1997-07-04 Sanofi Sa Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif de type oligosaccharide anionique
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
AU8211398A (en) * 1997-05-27 1998-12-30 Akzo Nobel N.V. Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
CA2377734A1 (fr) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Compositions d'heparine qui inhibent des facteurs de coagulation associes aux caillots
BR0113886A (pt) * 2000-09-08 2003-07-15 Hamilton Civic Hospitals Res Composição, composição farmacêutica, tratamento de combinação para prevenir ou inibir a geração ou atividade de trombina num paciente, método para inibir ou prevenir a geração ou atividade de trombina num paciente, uso de uma composição ou tratamento de combinação, uso de uma composição, uso e kit
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
EP1908768A1 (fr) * 2006-10-05 2008-04-09 Endotis Pharma Composés anticoagulants
JP2011522805A (ja) 2008-05-30 2011-08-04 モメンタ ファーマシューティカルズ インコーポレイテッド 糖構造ならびにそのような構造を作製および使用する方法
EP2323605A4 (fr) * 2008-09-10 2014-02-05 Syneron Medical Ltd Libération transdermique d oligosaccharides
ES2336297B1 (es) * 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
ES2939741T3 (es) * 2009-07-31 2023-04-26 Reliable Biopharmaceutical Llc Proceso para preparar fondaparinux sódico y productos intermedios útiles en la síntesis del mismo
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) * 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN103360439B (zh) 2012-04-02 2017-12-15 浙江海正药业股份有限公司 制备肝素五糖的新中间体及其制备方法
CN103145774A (zh) * 2013-03-21 2013-06-12 苏州鸿洋医药科技有限公司 一种抗凝戊糖及其制备方法
CN103601765B (zh) * 2013-09-02 2017-01-04 上海艾康睿医药科技有限公司 磺达肝癸钠及其中间体、以及制备方法
CA3228982A1 (fr) 2014-07-09 2016-01-14 Dsm Nutritional Products, Llc Compositions d'oligosaccharides et leurs procedes de production
JP6722697B2 (ja) 2015-01-26 2020-07-15 カデナ・バイオ・インコーポレイテッド 動物飼料として使用するためのオリゴ糖組成物及びその生成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments

Also Published As

Publication number Publication date
ATE76875T1 (de) 1992-06-15
NZ225453A (en) 1990-07-26
DE3871637D1 (en) 1992-07-09
PT88034B (pt) 1995-03-01
IE60006B1 (en) 1994-05-18
PT88034A (pt) 1989-06-30
FI883426A (fi) 1989-01-21
EP0300099A1 (fr) 1989-01-25
US4841041A (en) 1989-06-20
AU603236B2 (en) 1990-11-08
DK399588D0 (da) 1988-07-15
AU1922688A (en) 1989-01-27
KR890002211A (ko) 1989-04-10
ES2043786T3 (es) 1994-01-01
EP0301618A3 (en) 1989-02-15
GR3005518T3 (fr) 1993-06-07
CA1313867C (fr) 1993-02-23
DK399588A (da) 1989-01-21
JP2703777B2 (ja) 1998-01-26
DE3871637T2 (de) 1993-06-03
KR970011304B1 (ko) 1997-07-09
FI90242B (fi) 1993-09-30
FI883426A0 (fi) 1988-07-19
IE882048L (en) 1989-01-20
FI90242C (fi) 1994-01-10
EP0301618B1 (fr) 1992-06-03
DK171678B1 (da) 1997-03-10
EP0301618A2 (fr) 1989-02-01
JPS6440492A (en) 1989-02-10

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