KR890002211A - 신규의 펜타사카라이드 - Google Patents

신규의 펜타사카라이드 Download PDF

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Publication number
KR890002211A
KR890002211A KR1019880008996A KR880008996A KR890002211A KR 890002211 A KR890002211 A KR 890002211A KR 1019880008996 A KR1019880008996 A KR 1019880008996A KR 880008996 A KR880008996 A KR 880008996A KR 890002211 A KR890002211 A KR 890002211A
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KR
South Korea
Prior art keywords
pentasaccharide
oso
nhso
hydrogen
represented
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KR1019880008996A
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English (en)
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KR970011304B1 (ko
Inventor
아드리안 안톤 반베켈 콘스탄트
베쯔 톰
띠뚜 모리스쁘
Original Assignee
에이. 디. 도우마, 에프. 지. 엠. 헤르만
악조 엔. 브이.
미쉘 드 하
사노피 에스. 아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에이. 디. 도우마, 에프. 지. 엠. 헤르만, 악조 엔. 브이., 미쉘 드 하, 사노피 에스. 아 filed Critical 에이. 디. 도우마, 에프. 지. 엠. 헤르만
Publication of KR890002211A publication Critical patent/KR890002211A/ko
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Publication of KR970011304B1 publication Critical patent/KR970011304B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

신규의 펜타사카라이드
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기식으로 표시되는 펜타사카라이드 ;
    상기식에서 R1은 수소 또는 알킬(C1-20), R2-R6, R12-R13은 수소 또는 SO3-부, R7-R9는 OH, OSO-3, NHSO-3 또는 NH-아실, R10은 COO-, CH2OH또는 CH2OSO-3부, 유입된 다양한 부의 전하는 약학적으로 허용 카운터 이온에 의해 보충된다.
  2. 제1항에 있어서, 다음과 같은 기가 각각 독립적인 것을 특징으로 하는 펜타사카라이드. R1은 C1-4탄소수의 알킬부로서 바람직하게는 메틸, R2-R4는 SO-3부, R6, R112-R13은 수소, R5, R11은 수소 또는 SO-3부, R7, R9는 -NHS03-또는 OSO-3부, R8은 NHSO3-부, R10은 COO-부 (D-글루쿠론산 배열).
  3. 제1항에 있어서, 하기식으로 표현된 펜타사카라이드.
    상기식에서 A는 적합한 양이온, R9는 NHSO-3-또는 OSO-3이다.
  4. 제1항에 있어서, 하기식으로 표현된 펜타사카라이드.
    상기식에서 A는 적합한 양이온, R9는 NHSO-3또는 OSO-3R5및 R111이 동일하지 않음을 조건으로 할때 R5, R11은 수소 또는 SO-3부이다.
  5. 제1항에 있어서, 하기식으로 표현되는 펜타사카라이드.
    상기식에서 A는 적합한 양이온, R9는 OSO-3또는 NHSO-33이다.
  6. 제3항, 제4항 또는 제5항에 있어서, 양이온은 알카리금속 양이온, 바람직하게는 소듐 이온인 것을 특징으로 하는 펜타사카라이드.
  7. 실제 사용되고 있는 방법 또는 문헌에 공지된 방법으로 제1항의 펜타사카라이드를 제조하는 방법.
  8. 명세서에 기재된 식(IV)의 테트라사카라이드 또는 이의 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008996A 1987-07-20 1988-07-19 펜타사카라이드 KR970011304B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87.201383.4 1987-07-20
EP87201383A EP0300099A1 (en) 1987-07-20 1987-07-20 New pentasaccharides

Publications (2)

Publication Number Publication Date
KR890002211A true KR890002211A (ko) 1989-04-10
KR970011304B1 KR970011304B1 (ko) 1997-07-09

Family

ID=8197647

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008996A KR970011304B1 (ko) 1987-07-20 1988-07-19 펜타사카라이드

Country Status (16)

Country Link
US (1) US4841041A (ko)
EP (2) EP0300099A1 (ko)
JP (1) JP2703777B2 (ko)
KR (1) KR970011304B1 (ko)
AT (1) ATE76875T1 (ko)
AU (1) AU603236B2 (ko)
CA (1) CA1313867C (ko)
DE (1) DE3871637T2 (ko)
DK (1) DK171678B1 (ko)
ES (1) ES2043786T3 (ko)
FI (1) FI90242C (ko)
GR (1) GR3005518T3 (ko)
IE (1) IE60006B1 (ko)
NZ (1) NZ225453A (ko)
PT (1) PT88034B (ko)
ZA (1) ZA884952B (ko)

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EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
US5382570A (en) * 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
ES2060284T3 (es) * 1990-04-23 1994-11-16 Sanofi Elf Un procedimiento para la preparacion de un derivado de carbohidrato que comprende una unidad de trisacarido.
US5529985A (en) * 1990-04-23 1996-06-25 Akzo Nobel Nv Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
US5668274A (en) * 1991-04-23 1997-09-16 Akzo Nobel N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2729574B1 (fr) * 1995-01-24 1997-07-04 Sanofi Sa Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif de type oligosaccharide anionique
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
BR9809478A (pt) * 1997-05-27 2000-06-20 Akzo Nobel Nv Uso de um oligossacarìdeo sintético, processos para prevenção de coagulação sanguìnea em um mamìfero e para prevenção de coagulação sanguìnea e um circuito sanguìneo extracorpóreo, e, composição farmacêutica adaptada para prevenir coagulação sanguìnea em um circuito sanguìneo extracorpóreo
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
IL154771A0 (en) * 2000-09-08 2003-10-31 Hamilton Civic Hospitals Res Antithrombotic compositions
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
EP1908768A1 (en) * 2006-10-05 2008-04-09 Endotis Pharma Anticoagulant compounds
CN102046781A (zh) 2008-05-30 2011-05-04 动量制药公司 糖结构以及制造和使用此类结构的方法
CA2735983A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
ES2336297B1 (es) * 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
US8288515B2 (en) * 2009-07-31 2012-10-16 Reliable Biopharmaceutical Corporation Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
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CN103601765B (zh) * 2013-09-02 2017-01-04 上海艾康睿医药科技有限公司 磺达肝癸钠及其中间体、以及制备方法
BR112017000345B1 (pt) 2014-07-09 2022-04-26 Cadena Bio, Inc Composições de oligossacarídeo, métodos para produção das mesmas e produto alimentar
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Also Published As

Publication number Publication date
EP0301618A2 (en) 1989-02-01
DE3871637D1 (en) 1992-07-09
CA1313867C (en) 1993-02-23
NZ225453A (en) 1990-07-26
FI90242B (fi) 1993-09-30
DE3871637T2 (de) 1993-06-03
AU1922688A (en) 1989-01-27
PT88034B (pt) 1995-03-01
EP0300099A1 (en) 1989-01-25
ES2043786T3 (es) 1994-01-01
IE882048L (en) 1989-01-20
EP0301618A3 (en) 1989-02-15
US4841041A (en) 1989-06-20
EP0301618B1 (en) 1992-06-03
FI883426A (fi) 1989-01-21
IE60006B1 (en) 1994-05-18
DK399588A (da) 1989-01-21
KR970011304B1 (ko) 1997-07-09
JP2703777B2 (ja) 1998-01-26
GR3005518T3 (ko) 1993-06-07
PT88034A (pt) 1989-06-30
JPS6440492A (en) 1989-02-10
DK171678B1 (da) 1997-03-10
FI883426A0 (fi) 1988-07-19
AU603236B2 (en) 1990-11-08
ZA884952B (en) 1989-01-13
DK399588D0 (da) 1988-07-15
ATE76875T1 (de) 1992-06-15
FI90242C (fi) 1994-01-10

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