DE3871637T2 - Pentasaccharide. - Google Patents

Pentasaccharide.

Info

Publication number
DE3871637T2
DE3871637T2 DE8888201383T DE3871637T DE3871637T2 DE 3871637 T2 DE3871637 T2 DE 3871637T2 DE 8888201383 T DE8888201383 T DE 8888201383T DE 3871637 T DE3871637 T DE 3871637T DE 3871637 T2 DE3871637 T2 DE 3871637T2
Authority
DE
Germany
Prior art keywords
pentasaccharides
new
activity
pentasaccharide
inactivate thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888201383T
Other languages
English (en)
Other versions
DE3871637D1 (en
Inventor
Boeckel Constant Adriaan A Van
Tom Beetz
Maurice Petitou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Elf Sanofi SA
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elf Sanofi SA, Akzo NV filed Critical Elf Sanofi SA
Application granted granted Critical
Publication of DE3871637D1 publication Critical patent/DE3871637D1/de
Publication of DE3871637T2 publication Critical patent/DE3871637T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
DE8888201383T 1987-07-20 1988-07-04 Pentasaccharide. Expired - Lifetime DE3871637T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87201383A EP0300099A1 (de) 1987-07-20 1987-07-20 Pentasaccharide

Publications (2)

Publication Number Publication Date
DE3871637D1 DE3871637D1 (en) 1992-07-09
DE3871637T2 true DE3871637T2 (de) 1993-06-03

Family

ID=8197647

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888201383T Expired - Lifetime DE3871637T2 (de) 1987-07-20 1988-07-04 Pentasaccharide.

Country Status (16)

Country Link
US (1) US4841041A (de)
EP (2) EP0300099A1 (de)
JP (1) JP2703777B2 (de)
KR (1) KR970011304B1 (de)
AT (1) ATE76875T1 (de)
AU (1) AU603236B2 (de)
CA (1) CA1313867C (de)
DE (1) DE3871637T2 (de)
DK (1) DK171678B1 (de)
ES (1) ES2043786T3 (de)
FI (1) FI90242C (de)
GR (1) GR3005518T3 (de)
IE (1) IE60006B1 (de)
NZ (1) NZ225453A (de)
PT (1) PT88034B (de)
ZA (1) ZA884952B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333243A3 (de) * 1988-03-10 1989-09-27 Akzo N.V. Sulphatiertes K5-Antigen und seine Fragmente
US5529985A (en) * 1990-04-23 1996-06-25 Akzo Nobel Nv Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
DE69100275T2 (de) * 1990-04-23 1993-12-02 Akzo Nv Eine Trisaccharideinheit enthaltende Kohlenhydratderivate.
US5382570A (en) * 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US5668274A (en) * 1991-04-23 1997-09-16 Akzo Nobel N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2729574B1 (fr) * 1995-01-24 1997-07-04 Sanofi Sa Dispositif d'ionophorese pour l'administration transcutanee d'un principe actif de type oligosaccharide anionique
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
AU8211398A (en) * 1997-05-27 1998-12-30 Akzo Nobel N.V. Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
EP1192187A1 (de) * 1999-06-30 2002-04-03 Hamilton Civic Hospitals Research Development, Inc. Heparinzusammensetzungen, die gerinnselzugehörige gerinnungsfakoren verhindert
CZ2003961A3 (cs) * 2000-09-08 2003-10-15 Hamilton Civic Hospitals Research Development, Inc. Farmaceutický prostředek k inhibici nebo prevenci tvorby či aktivity thrombinu
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
EP1908768A1 (de) * 2006-10-05 2008-04-09 Endotis Pharma Koagulationshemmende Zusammensetzungen
CN102046781A (zh) 2008-05-30 2011-05-04 动量制药公司 糖结构以及制造和使用此类结构的方法
US20110150976A1 (en) * 2008-09-10 2011-06-23 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
ES2336297B1 (es) * 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
ES2939741T3 (es) * 2009-07-31 2023-04-26 Reliable Biopharmaceutical Llc Proceso para preparar fondaparinux sódico y productos intermedios útiles en la síntesis del mismo
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) * 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN103360439B (zh) * 2012-04-02 2017-12-15 浙江海正药业股份有限公司 制备肝素五糖的新中间体及其制备方法
CN103145774A (zh) * 2013-03-21 2013-06-12 苏州鸿洋医药科技有限公司 一种抗凝戊糖及其制备方法
CN103601765B (zh) * 2013-09-02 2017-01-04 上海艾康睿医药科技有限公司 磺达肝癸钠及其中间体、以及制备方法
CN107001528A (zh) 2014-07-09 2017-08-01 米德瑞（美国）有限公司 低聚糖组合物及其制备方法
CA2975095A1 (en) 2015-01-26 2016-08-04 Cadena Bio, Inc. Oligosaccharide compositions for use as animal feed and methods of producing thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments

Also Published As

Publication number Publication date
FI90242C (fi) 1994-01-10
AU1922688A (en) 1989-01-27
FI883426A (fi) 1989-01-21
NZ225453A (en) 1990-07-26
IE60006B1 (en) 1994-05-18
DK399588A (da) 1989-01-21
JPS6440492A (en) 1989-02-10
FI90242B (fi) 1993-09-30
CA1313867C (en) 1993-02-23
EP0300099A1 (de) 1989-01-25
PT88034A (pt) 1989-06-30
AU603236B2 (en) 1990-11-08
EP0301618B1 (de) 1992-06-03
KR890002211A (ko) 1989-04-10
PT88034B (pt) 1995-03-01
FI883426A0 (fi) 1988-07-19
ES2043786T3 (es) 1994-01-01
ZA884952B (en) 1989-01-13
GR3005518T3 (de) 1993-06-07
DK171678B1 (da) 1997-03-10
EP0301618A3 (en) 1989-02-15
KR970011304B1 (ko) 1997-07-09
DK399588D0 (da) 1988-07-15
DE3871637D1 (en) 1992-07-09
JP2703777B2 (ja) 1998-01-26
IE882048L (en) 1989-01-20
EP0301618A2 (de) 1989-02-01
US4841041A (en) 1989-06-20
ATE76875T1 (de) 1992-06-15

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Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER 2. PATENTINHABER LAUTET RICHTIG: ELF SANOFI, PARIS, FR

8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL SANOFI-SYNTHEL

8328 Change in the person/name/address of the agent

Free format text: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAELTE, 81541 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR