DK171678B1 - Pentasaccharider og mellemprodukter herfor - Google Patents

Pentasaccharider og mellemprodukter herfor Download PDF

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Publication number
DK171678B1
DK171678B1 DK399588A DK399588A DK171678B1 DK 171678 B1 DK171678 B1 DK 171678B1 DK 399588 A DK399588 A DK 399588A DK 399588 A DK399588 A DK 399588A DK 171678 B1 DK171678 B1 DK 171678B1
Authority
DK
Denmark
Prior art keywords
formula
hydrogen
sulfo
pentasaccharide
oso
Prior art date
Application number
DK399588A
Other languages
Danish (da)
English (en)
Other versions
DK399588A (da
DK399588D0 (da
Inventor
Constant Adriaan Anton Boeckel
Tom Beetz
Maurice Petitou
Original Assignee
Sanofi Sa
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Akzo Nv filed Critical Sanofi Sa
Publication of DK399588D0 publication Critical patent/DK399588D0/da
Publication of DK399588A publication Critical patent/DK399588A/da
Application granted granted Critical
Publication of DK171678B1 publication Critical patent/DK171678B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK399588A 1987-07-20 1988-07-15 Pentasaccharider og mellemprodukter herfor DK171678B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87201383A EP0300099A1 (de) 1987-07-20 1987-07-20 Pentasaccharide
EP87201383 1987-07-20

Publications (3)

Publication Number Publication Date
DK399588D0 DK399588D0 (da) 1988-07-15
DK399588A DK399588A (da) 1989-01-21
DK171678B1 true DK171678B1 (da) 1997-03-10

Family

ID=8197647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK399588A DK171678B1 (da) 1987-07-20 1988-07-15 Pentasaccharider og mellemprodukter herfor

Country Status (16)

Country Link
US (1) US4841041A (de)
EP (2) EP0300099A1 (de)
JP (1) JP2703777B2 (de)
KR (1) KR970011304B1 (de)
AT (1) ATE76875T1 (de)
AU (1) AU603236B2 (de)
CA (1) CA1313867C (de)
DE (1) DE3871637T2 (de)
DK (1) DK171678B1 (de)
ES (1) ES2043786T3 (de)
FI (1) FI90242C (de)
GR (1) GR3005518T3 (de)
IE (1) IE60006B1 (de)
NZ (1) NZ225453A (de)
PT (1) PT88034B (de)
ZA (1) ZA884952B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333243A3 (de) * 1988-03-10 1989-09-27 Akzo N.V. Sulphatiertes K5-Antigen und seine Fragmente
US5529985A (en) * 1990-04-23 1996-06-25 Akzo Nobel Nv Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
IE64378B1 (en) * 1990-04-23 1995-07-26 Akzo Nv Carbohydrate derivatives comprising a trisaccharide unit
US5382570A (en) * 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US5668274A (en) * 1991-04-23 1997-09-16 Akzo Nobel N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
AU4626196A (en) * 1995-01-24 1996-08-14 Akzo Nobel N.V. Iontophoresis device for the transcutaneous delivery of an active principle such as an anionic oligosaccharide
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
CA2289522A1 (en) * 1997-05-27 1998-12-03 Akzo Nobel Nv Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
IL126893A (en) 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
AU782661B2 (en) * 1999-06-30 2005-08-18 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
US20040038932A1 (en) * 2000-09-08 2004-02-26 Jack Hirsh Antithrombotic compositions
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
EP1908768A1 (de) * 2006-10-05 2008-04-09 Endotis Pharma Koagulationshemmende Zusammensetzungen
CA2724910C (en) 2008-05-30 2015-09-01 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
ES2336297B1 (es) * 2008-10-08 2011-01-24 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido.
EP3666786A1 (de) 2009-07-31 2020-06-17 Reliable Biopharmaceutical Corporation Verfahren zur herstellung von fondaparinux-natrium und zwischenprodukte zu deren synthese
FR2949114B1 (fr) * 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
EP2614089A1 (de) 2010-09-10 2013-07-17 Sanofi-Aventis Biotinylierte polysaccharide mit antithrombotischer wirkung und erhöhter stoffwechselstabilität
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN103360439B (zh) 2012-04-02 2017-12-15 浙江海正药业股份有限公司 制备肝素五糖的新中间体及其制备方法
CN103145774A (zh) * 2013-03-21 2013-06-12 苏州鸿洋医药科技有限公司 一种抗凝戊糖及其制备方法
CN103601765B (zh) * 2013-09-02 2017-01-04 上海艾康睿医药科技有限公司 磺达肝癸钠及其中间体、以及制备方法
CA3228982A1 (en) 2014-07-09 2016-01-14 Dsm Nutritional Products, Llc Oligosaccharide compositions and methods for producing thereof
US10849337B2 (en) 2015-01-26 2020-12-01 Cadena Bio, Inc. Oligosaccharide compositions for use as animal feed and methods of producing thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments

Also Published As

Publication number Publication date
US4841041A (en) 1989-06-20
DE3871637D1 (en) 1992-07-09
DK399588A (da) 1989-01-21
PT88034B (pt) 1995-03-01
IE882048L (en) 1989-01-20
AU603236B2 (en) 1990-11-08
ES2043786T3 (es) 1994-01-01
PT88034A (pt) 1989-06-30
DK399588D0 (da) 1988-07-15
FI90242C (fi) 1994-01-10
JPS6440492A (en) 1989-02-10
CA1313867C (en) 1993-02-23
IE60006B1 (en) 1994-05-18
ATE76875T1 (de) 1992-06-15
AU1922688A (en) 1989-01-27
NZ225453A (en) 1990-07-26
ZA884952B (en) 1989-01-13
KR890002211A (ko) 1989-04-10
EP0301618A3 (en) 1989-02-15
EP0301618B1 (de) 1992-06-03
EP0300099A1 (de) 1989-01-25
GR3005518T3 (de) 1993-06-07
JP2703777B2 (ja) 1998-01-26
KR970011304B1 (ko) 1997-07-09
DE3871637T2 (de) 1993-06-03
FI90242B (fi) 1993-09-30
EP0301618A2 (de) 1989-02-01
FI883426A (fi) 1989-01-21
FI883426A0 (fi) 1988-07-19

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