ZA874860B - Novel metal chelate resins - Google Patents

Novel metal chelate resins

Info

Publication number
ZA874860B
ZA874860B ZA874860A ZA874860A ZA874860B ZA 874860 B ZA874860 B ZA 874860B ZA 874860 A ZA874860 A ZA 874860A ZA 874860 A ZA874860 A ZA 874860A ZA 874860 B ZA874860 B ZA 874860B
Authority
ZA
South Africa
Prior art keywords
metal chelate
chelate resins
novel metal
complexed
proteins
Prior art date
Application number
ZA874860A
Other languages
English (en)
Inventor
Doebeli Heinz
Hochuli Erich
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4241469&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA874860(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA874860B publication Critical patent/ZA874860B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3265—Non-macromolecular compounds with an organic functional group containing a metal, e.g. a metal affinity ligand

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Polymerisation Methods In General (AREA)
ZA874860A 1986-07-10 1987-07-03 Novel metal chelate resins ZA874860B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH278286 1986-07-10

Publications (1)

Publication Number Publication Date
ZA874860B true ZA874860B (en) 1988-01-11

Family

ID=4241469

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA874860A ZA874860B (en) 1986-07-10 1987-07-03 Novel metal chelate resins

Country Status (13)

Country Link
US (1) US4877830A (fr)
EP (1) EP0253303B1 (fr)
JP (2) JPH0822382B2 (fr)
AT (1) ATE76866T1 (fr)
AU (1) AU596674B2 (fr)
CA (1) CA1304886C (fr)
DE (1) DE3779501D1 (fr)
DK (2) DK172602B1 (fr)
IE (1) IE60468B1 (fr)
IL (1) IL83079A (fr)
NZ (1) NZ220948A (fr)
PH (1) PH23746A (fr)
ZA (1) ZA874860B (fr)

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CA1340522C (fr) * 1987-03-10 1999-05-04 Heinz Dobeli Proteins hybrides renfermant des histidines voisines pour une purification amelioree
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ATE145010T1 (de) * 1989-08-19 1996-11-15 Qiagen Gmbh Verfahren und vorrichtung zur trennung und detektion von komponenten eines stoffgemisches durch temperaturgradienten-gelelektrophorese
US5266686A (en) * 1992-09-25 1993-11-30 Pierce Chemical Company Method for isolation and purification of enzyme-antibody conjugates
CA2125467C (fr) * 1993-07-06 2001-02-06 Heinz Dobeli Methode de preparation de polypeptides, proteines ou peptides hydrophobes
SE9303822D0 (sv) * 1993-11-18 1993-11-18 Kabi Pharmacia Ab Method for purification
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
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DE69730551T2 (de) 1996-04-15 2005-09-01 Givaudan S.A. Hydroxyperoxide Lyasen
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US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
WO1998058952A1 (fr) * 1997-06-24 1998-12-30 Proteus Molecular Design Limited Derives d'angiotensine
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
CA2277372C (fr) * 1998-07-13 2011-03-15 Tran Quang Minh Resines metalliques a affinite immobilisee
ES2248936T3 (es) 1999-03-04 2006-03-16 F. KURT RETSCH GMBH & CO. KG Procedimiento y dispositivo para descomponer material biologico.
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JP2001029783A (ja) * 1999-07-13 2001-02-06 Tran Quang Minh 親和性固定化金属樹脂
DE60026641T2 (de) * 1999-07-15 2007-01-25 Qiagen Gmbh Verfahren zur Trennung von teilchenförmigen Substraten aus einer Lösung indem man den Teilchenverlust minimiert
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
US6623655B1 (en) * 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
GB0028879D0 (en) * 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
WO2003050540A2 (fr) * 2001-12-05 2003-06-19 Large Scale Biology Corporation Procede et appareil souples pour flux de production eleve et purification de multiples proteines
US7879621B2 (en) * 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
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US20040224329A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Three-dimensional solid phase extraction surfaces
US7151167B2 (en) * 2002-06-10 2006-12-19 Phynexus, Inc. Open channel solid phase extraction systems and methods
EP1518115A2 (fr) * 2002-06-10 2005-03-30 Phynexus, Inc. Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
AU2003286553A1 (en) * 2002-10-18 2004-05-04 Promega Corporation Methods for separating molecules
US7799526B2 (en) * 2002-11-21 2010-09-21 The University Of North Carolina At Chapel Hill Phosphoprotein detection reagent and methods of making and using the same
SE526214C2 (sv) * 2003-02-28 2005-07-26 Amersham Biosciences Ab Ett sätt att generera metallkelaterande affinitetsligander
SE0301011D0 (sv) * 2003-04-04 2003-04-04 Amersham Biosciences Ab Preparation of a metal chelating separation medium
US20040241721A1 (en) * 2003-05-08 2004-12-02 Gjerde Douglas T. Open channel solid phase extraction systems and methods
EA008305B1 (ru) * 2003-05-23 2007-04-27 Аплаген Гмбх Синтез пептидов
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US20050123932A1 (en) * 2003-12-09 2005-06-09 Mekbib Astatke Nucleic acid-chelating agent conjugates
US7276362B2 (en) * 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
DE102004038134B4 (de) 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
WO2006056443A2 (fr) * 2004-11-24 2006-06-01 Aplagen Gmbh Procede de synthese et purification de peptides en phase solide
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CA2648732A1 (fr) * 2005-06-23 2006-12-28 Aplagen Gmbh Composes supravalents
US20070065514A1 (en) * 2005-09-22 2007-03-22 Howell Mark D Method for enhancing immune responses in mammals
US20090238822A1 (en) * 2005-10-13 2009-09-24 Virexx Medical Corp. Chimeric Hepatitis C Virus Antigens For Eliciting an Immune Response
WO2007120999A2 (fr) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chélation de monomères et de polymères
GB0610479D0 (en) * 2006-05-26 2006-07-05 Ge Healthcare Bio Sciences Ab A method for generating metal chelating affinity ligands
EP2164591B1 (fr) * 2007-07-09 2013-05-08 GE Healthcare Bio-Sciences AB Procede pour la preparation d'un agent d'adsorption biomoleculaire
US20090162845A1 (en) 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
JP2011522538A (ja) * 2008-06-04 2011-08-04 タレクリス・バイオセラピユーテイクス・インコーポレーテツド プラスミン製造のための組成物、方法およびキット
EP2192410B1 (fr) 2008-11-26 2012-07-11 Corning Incorporated Capture par affinité de nanoparticules pour système de détection indépendant des étiquettes
ES2552337T3 (es) 2009-03-03 2015-11-27 Grifols Therapeutics Inc. Procedimientos para la preparación de plasminógeno
WO2011043835A1 (fr) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides qui se lient à l'il-23r
EP2362220A1 (fr) 2010-02-25 2011-08-31 Corning Incorporated Hydrogel d'affinité et procédés de détection indépendants de l'étiquette correspondants
HU230585B1 (hu) 2012-05-30 2017-01-30 Budapesti Műszaki és Gazdaságtudományi Egyetem Fehérjék megkötésére és elválasztására alkalmas lantanida fémionokkal komplexált hordozók
JP2014113108A (ja) * 2012-12-11 2014-06-26 Tokyo Medical Univ タンパク質の可溶化活性を有する多量体タンパク質およびその用途
CA3121103C (fr) 2018-11-28 2023-10-10 Cube Biotech Gmbh Materiau chelateur en phase solide, son procede de production et son utilisation pour la purification de proteines
CN109535274B (zh) * 2018-11-30 2021-02-19 淮阴工学院 一种蒲菜多糖脱蛋白脱色的方法
EP4288411A1 (fr) 2021-02-02 2023-12-13 Cube Biotech GmbH Chélateur soluble pour le ciblage de protéines recombinantes
CN113150194A (zh) * 2021-02-24 2021-07-23 广东昊邦医药健康有限责任公司 金属螯合树脂及其制备方法、应用
CN117339580B (zh) * 2023-12-05 2024-04-02 凯莱英生命科学技术(天津)有限公司 螯合载体、其制备方法及应用

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US4530963A (en) * 1982-08-20 1985-07-23 Devoe-Holbein International, N.V. Insoluble chelating compositions
CA1304886C (fr) * 1986-07-10 1992-07-07 Heinz Dobeli Resines chelatant des metaux

Also Published As

Publication number Publication date
IE60468B1 (en) 1994-07-13
PH23746A (en) 1989-11-03
NZ220948A (en) 1990-07-26
EP0253303B1 (fr) 1992-06-03
JPH0822382B2 (ja) 1996-03-06
EP0253303A2 (fr) 1988-01-20
DK285187D0 (da) 1987-06-03
IL83079A0 (en) 1987-12-31
AU596674B2 (en) 1990-05-10
US4877830A (en) 1989-10-31
DK285187A (da) 1988-01-11
JP2562571B2 (ja) 1996-12-11
DE3779501D1 (de) 1992-07-09
JPH0899944A (ja) 1996-04-16
AU7524587A (en) 1988-01-14
DK172602B1 (da) 1999-02-22
CA1304886C (fr) 1992-07-07
DK149397A (da) 1997-12-19
EP0253303A3 (en) 1989-05-24
IE871842L (en) 1988-01-10
JPS6344947A (ja) 1988-02-25
ATE76866T1 (de) 1992-06-15
DK172891B1 (da) 1999-09-13
IL83079A (en) 1991-11-21

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