ZA855696B - Method for the production of 2'-deoxyadenosine compounds - Google Patents
Method for the production of 2'-deoxyadenosine compoundsInfo
- Publication number
- ZA855696B ZA855696B ZA855696A ZA855696A ZA855696B ZA 855696 B ZA855696 B ZA 855696B ZA 855696 A ZA855696 A ZA 855696A ZA 855696 A ZA855696 A ZA 855696A ZA 855696 B ZA855696 B ZA 855696B
- Authority
- ZA
- South Africa
- Prior art keywords
- deoxyadenosine
- production
- compounds
- deoxyadenosine compounds
- dichloropurine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63819284A | 1984-08-06 | 1984-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA855696B true ZA855696B (en) | 1986-04-30 |
Family
ID=24559020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA855696A ZA855696B (en) | 1984-08-06 | 1985-07-29 | Method for the production of 2'-deoxyadenosine compounds |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0173059B1 (ja) |
| JP (2) | JPS61106594A (ja) |
| AT (1) | ATE48278T1 (ja) |
| AU (1) | AU572673B2 (ja) |
| CA (1) | CA1269659A (ja) |
| DE (1) | DE3574472D1 (ja) |
| DK (1) | DK165453C (ja) |
| ES (1) | ES8606383A1 (ja) |
| ZA (1) | ZA855696B (ja) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0217199A (ja) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | ２’−デオキシ−β−アデノシンの製造方法 |
| JPH02160799A (ja) * | 1988-12-13 | 1990-06-20 | Yuki Gosei Kogyo Co Ltd | ２′−デオキシ−β−アデノシンの製造法 |
| US5208327A (en) * | 1991-12-18 | 1993-05-04 | Ortho Pharmaceutical Corporation | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
| US7572909B2 (en) * | 2002-09-25 | 2009-08-11 | Brigham Young University | Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine |
| SG160391A1 (en) | 2004-12-22 | 2010-04-29 | Merck Serono Sa | Cladribine regimen for treating multiple sclerosis |
| US9925151B2 (en) | 2006-05-24 | 2018-03-27 | Merck Serono Sa | Cladribine regimen for treating multiple sclerosis |
| SI1932918T1 (sl) | 2006-12-15 | 2010-02-26 | Explora Lab Sa | Postopek izdelave kladribina |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| WO2010075517A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside analogs |
| CL2009002207A1 (es) | 2008-12-23 | 2011-02-18 | Gilead Pharmasset Llc | Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c. |
| SG172363A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Synthesis of purine nucleosides |
| US8232387B2 (en) | 2009-08-18 | 2012-07-31 | Scinopharm Taiwan, Ltd. | Process for the preparation of cladribine |
| EP2343074A1 (en) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Use of purine analogues for treating airway diseases |
| WO2011113476A2 (en) | 2010-03-16 | 2011-09-22 | Cilag Ag | Method for producing 2'-deoxyadenosine compounds |
| AP3515A (en) | 2010-03-31 | 2016-01-11 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| GB201401465D0 (en) | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
| EP2993177A1 (en) | 2014-09-05 | 2016-03-09 | Technische Universität Berlin | A chemo-enzymatic preparation method for purine nucleosides and their deaza- and aza- analogues |
| GB2564717A (en) | 2017-07-21 | 2019-01-23 | Chord Therapeutics S A R L | Use of cladribine for treating autoimmune neuromuscular disease |
| BR112020010282A2 (pt) | 2017-11-24 | 2020-11-17 | Merck Patent Gmbh | regime de cladribina para uso no tratamento de formas progressivas de esclerose múltipla |
| JP2023541877A (ja) | 2020-09-10 | 2023-10-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 自己免疫障害の処置のための新規の処置レジメン |
| GB2601786A (en) | 2020-12-10 | 2022-06-15 | Chord Therapeutics S A R L | Use of cladribine for treating immune brain disease |
| EP4302091A1 (en) | 2021-03-03 | 2024-01-10 | Ares Trading S.A. | Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3225029A (en) * | 1962-03-08 | 1965-12-21 | Yamaoka Naotaka | Process for the preparation of nucleosides and products obtained thereby |
| US3225009A (en) * | 1962-05-21 | 1965-12-21 | Scott Paper Co | Ethylene dicarboxylic esters of 1,2 alkane carbonates, polymers, and copolymers thereof |
| DE1795357A1 (de) * | 1968-09-18 | 1972-01-05 | Schering Ag | 2-Thio-pyrimidin-nucleoside |
| EP0184365B1 (en) * | 1984-12-04 | 1993-08-04 | Eli Lilly And Company | Improvements in the treatment of tumors in mammals |
-
1985
- 1985-07-15 CA CA000486828A patent/CA1269659A/en not_active Expired - Lifetime
- 1985-07-17 EP EP85108955A patent/EP0173059B1/en not_active Expired
- 1985-07-17 DE DE8585108955T patent/DE3574472D1/de not_active Expired - Lifetime
- 1985-07-17 AT AT85108955T patent/ATE48278T1/de not_active IP Right Cessation
- 1985-07-18 AU AU45138/85A patent/AU572673B2/en not_active Expired
- 1985-07-29 ZA ZA855696A patent/ZA855696B/xx unknown
- 1985-08-02 JP JP60170973A patent/JPS61106594A/ja active Granted
- 1985-08-05 ES ES545888A patent/ES8606383A1/es not_active Expired
- 1985-08-06 DK DK357585A patent/DK165453C/da not_active IP Right Cessation
-
1989
- 1989-07-11 JP JP1178889A patent/JPH0256497A/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61106594A (ja) | 1986-05-24 |
| DK165453C (da) | 1993-04-13 |
| CA1269659A (en) | 1990-05-29 |
| JPH02359B2 (ja) | 1990-01-08 |
| JPH0256497A (ja) | 1990-02-26 |
| EP0173059A3 (en) | 1987-04-29 |
| EP0173059B1 (en) | 1989-11-29 |
| EP0173059A2 (en) | 1986-03-05 |
| DK165453B (da) | 1992-11-30 |
| AU572673B2 (en) | 1988-05-12 |
| ATE48278T1 (de) | 1989-12-15 |
| AU4513885A (en) | 1986-02-13 |
| DE3574472D1 (de) | 1990-01-04 |
| DK357585D0 (da) | 1985-08-06 |
| ES545888A0 (es) | 1986-04-01 |
| ES8606383A1 (es) | 1986-04-01 |
| DK357585A (da) | 1986-02-07 |
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