ZA852971B - New process for the synthesis of pyrido-imidazo rifamycins - Google Patents

New process for the synthesis of pyrido-imidazo rifamycins

Info

Publication number
ZA852971B
ZA852971B ZA852971A ZA852971A ZA852971B ZA 852971 B ZA852971 B ZA 852971B ZA 852971 A ZA852971 A ZA 852971A ZA 852971 A ZA852971 A ZA 852971A ZA 852971 B ZA852971 B ZA 852971B
Authority
ZA
South Africa
Prior art keywords
pyrido
synthesis
new process
rifamycins
imidazo
Prior art date
Application number
ZA852971A
Other languages
English (en)
Inventor
Vincenzo Cannata
Gian Franco Tamagnone
Silvano Piani
Egidio Marchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of ZA852971B publication Critical patent/ZA852971B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA852971A 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins ZA852971B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (1)

Publication Number Publication Date
ZA852971B true ZA852971B (en) 1985-12-24

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852971A ZA852971B (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins

Country Status (18)

Country Link
US (1) US4557866A (OSRAM)
EP (1) EP0161534B1 (OSRAM)
JP (1) JPS60252483A (OSRAM)
AR (1) AR241913A1 (OSRAM)
AT (1) ATE46512T1 (OSRAM)
AU (1) AU568934B2 (OSRAM)
CA (1) CA1215708A (OSRAM)
DE (1) DE3573120D1 (OSRAM)
DK (1) DK162647C (OSRAM)
ES (1) ES8603489A1 (OSRAM)
FI (1) FI81101C (OSRAM)
GR (1) GR851144B (OSRAM)
IE (1) IE58392B1 (OSRAM)
IT (1) IT1199374B (OSRAM)
NO (1) NO164242C (OSRAM)
PH (1) PH22007A (OSRAM)
PT (1) PT80446B (OSRAM)
ZA (1) ZA852971B (OSRAM)

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US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
ES2522895T3 (es) * 2005-03-03 2014-11-19 Alfa Wassermann S.P.A. Nuevas formas polimorfas de rifaximina, procedimientos para su producción y uso de las mismas en preparados medicinales
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
KR101398648B1 (ko) 2006-03-09 2014-06-27 샐릭스 파마슈티컬스 인코포레이티드 리팍시민 직장 기능장애 치료 제제
JP5844961B2 (ja) 2006-08-02 2016-01-20 サリックス ファーマシューティカルズ， インコーポレイテッド 放射線直腸ｓ状結腸炎を処置するための組成物および方法
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
EP2069363B1 (en) * 2006-09-22 2013-03-20 Cipla Ltd. Rifaximin in an amorphous form
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
US8067429B2 (en) * 2008-02-25 2011-11-29 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
AU2009219240B2 (en) 2008-02-26 2014-10-16 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
AU2009244190B2 (en) 2008-05-07 2016-02-25 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
SI3628319T1 (sl) 2008-10-02 2024-04-30 Salix Pharmaceuticals, Ltd. Zdravljenje jetrne encefalopatije z rifaksiminom
KR20110107806A (ko) 2008-12-10 2011-10-04 시플라 리미티드 리팍시민 복합체
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
NZ596851A (en) 2009-06-02 2013-10-25 Salix Pharmaceuticals Ltd Methods of treating hepatic encephalopathy
RU2582940C2 (ru) 2009-09-13 2016-04-27 Саликс Фармасьютикалз, Лтд. Способы лечения синдрома раздраженного кишечника (срк)
CA2781580A1 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
WO2011103246A1 (en) 2010-02-18 2011-08-25 Salix Pharmaceuticals, Ltd. Methods for treating infection
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
EP2582707A4 (en) * 2010-06-16 2014-01-08 Apotex Pharmachem Inc POLYMORPHIC FORMS OF RIFAXIMINE
SMT202000390T1 (it) 2010-07-12 2020-09-10 Salix Pharmaceuticals Inc Formulazioni di rifaximina e loro usi
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
SG192122A1 (en) 2011-02-11 2013-08-30 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof
AU2012251385A1 (en) 2011-05-02 2013-11-21 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
CA2854380A1 (en) 2011-11-02 2013-05-10 Salix Pharmaceuticals, Ltd. Methods for treating irritable bowel syndrome (ibs) and infections
US9359374B2 (en) 2012-06-13 2016-06-07 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
CN105142636A (zh) 2013-03-15 2015-12-09 意大利阿尔法韦士曼制药公司 用于治疗阴道感染的利福昔明
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
MX374340B (es) 2013-04-12 2025-03-06 Alfasigma Spa Administracion de farmacos antiinflamatorios no esteroidales y composiciones, metodos y sistemas relacionados.
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
WO2015171493A1 (en) 2014-05-04 2015-11-12 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
KR102362719B1 (ko) 2014-05-12 2022-02-14 알파시그마 에스.피.에이. 리팍시민의 신규한 용매화 결정 형태, 생산물, 조성물 및 이의 용도
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
CN110072525B (zh) 2016-09-30 2022-12-02 萨利克斯药品公司 利福昔明的固态分散形式
PL3645539T3 (pl) * 2017-06-26 2021-10-25 Biofer S.P.A. Pochodne pirydoimidazoryfamycyny jako środek przeciwbakteryjny

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
GR851144B (OSRAM) 1985-11-25
AU4251585A (en) 1985-11-21
NO164242B (no) 1990-06-05
JPH0469634B2 (OSRAM) 1992-11-06
DE3573120D1 (en) 1989-10-26
NO851921L (no) 1985-11-18
IE851191L (en) 1985-11-15
ES543115A0 (es) 1986-01-01
PH22007A (en) 1988-05-02
IT8403463A0 (it) 1984-05-15
NO164242C (no) 1990-09-12
IT1199374B (it) 1988-12-30
DK214685D0 (da) 1985-05-14
FI851907A0 (fi) 1985-05-14
AU568934B2 (en) 1988-01-14
EP0161534B1 (en) 1989-09-20
FI81101B (fi) 1990-05-31
DK162647B (da) 1991-11-25
PT80446B (pt) 1987-11-11
US4557866A (en) 1985-12-10
AR241913A1 (es) 1993-01-29
CA1215708A (en) 1986-12-23
ATE46512T1 (de) 1989-10-15
EP0161534A3 (en) 1987-03-04
JPS60252483A (ja) 1985-12-13
PT80446A (en) 1985-06-01
EP0161534A2 (en) 1985-11-21
FI851907L (fi) 1985-11-16
DK214685A (da) 1985-11-16
ES8603489A1 (es) 1986-01-01
DK162647C (da) 1992-04-13
FI81101C (fi) 1990-09-10
IE58392B1 (en) 1993-09-08

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